BMRB: 16892

NS2 [60-99]

Authors

Montserret, R., Bartenschlager, R., Penin, F.

Assembly

NS2[60-99]

Entity

1. NS2[60-99] (polymer, Thiol state: all free), 40 monomers, 4271.263 Da Detail

GRDAVILLTC AIHPELIFTI TKILLAILGP LMVLQAGITK

Formula weight

4271.263 Da

Source organism

Hepacivirus C

Exptl. method

solution NMR

Refine. method

torsion angle dynamics

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 87.4 %, Completeness (bb): 97.5 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	87.4 % (209 of 239)	87.4 % (209 of 239)
Backbone	97.5 % (79 of 81)	97.5 % (79 of 81)
Sidechain	82.3 % (130 of 158)	82.3 % (130 of 158)
Aromatic	28.6 % (2 of 7)	28.6 % (2 of 7)
Methyl	90.5 % (38 of 42)	90.5 % (38 of 42)

1. NS2[60-99]

GRDAVILLTC AIHPELIFTI TKILLAILGP LMVLQAGITK

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Sample

Solvent system trifluoroethanol/water, Pressure 1 atm, Temperature 298 K, pH 6.0, Details mM solution of TMS3 in 50% v/v Trifluoroethanol/water

#	Name	Isotope labeling	Type	Concentration
1	NS2[60-99]	natural abundance		0.4 mM
2	TFE	[U-2H]		50 % v/v
3	H2O	natural abundance		50 % v/v
4	DSS	natural abundance		0.2 uM

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Protein Blocks Logo

Calculated from 41 models in PDB: 2KWZ, Strand ID: A Detail

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Release date

2011-05-18

Citation

Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly
Jirasko, V., Montserret, R., Lee, J., Gouttenoire, J., Moradpour, D., Penin, F., Bartenschlager, R.
PLoS Pathog. (2010), 6, e1001233-e1001233, PubMed 21187906 , DOI 10.1371/journal.ppat.1001233 , Abstract

Related entities 1. NS2[60-99], : 1 : 1 : 29 entities Detail

Interaction partners 1. NS2[60-99], : 350 interactors Detail

Experiments performed 3 experiments Detail