BMRB: 17227

SOLUTION STRUCTURE OF GS-alfa-Ktx5.4 SYNTHETIC SCORPION LIKE

Authors

Del Rio-Portilla, F., Ramirez-Cordero, B.E., Brieba-De Castro, L.

Assembly

GS-alfa-Ktx5.4 SCORPION TOXIN

Entity

1. GS-alfa-Ktx5.4 SCORPION TOXIN (polymer, Thiol state: all disulfide bound), 33 monomers, 3609.273 Da Detail

GSAFCNLRRC ELSCRSLGLL GKCIGEECKC VPY

Formula weight

3609.273 Da

Source organism

Mesobuthus tamulus

Exptl. method

NMR

Refine. method

TORSION ANGLE DYNAMICS, MOLECULAR DYNAMICS

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 97.0 %, Completeness: 90.2 %, Completeness (bb): 91.3 % Detail

Download

• NMR-STAR v3.1 (partial)
• BMRB/XML (partial)
• CSV
• TSV

Polymer type: polypeptide(L)

	Total	1H
All	90.2 % (174 of 193)	90.2 % (174 of 193)
Backbone	91.3 % (63 of 69)	91.3 % (63 of 69)
Sidechain	89.5 % (111 of 124)	89.5 % (111 of 124)
Aromatic	44.4 % (4 of 9)	44.4 % (4 of 9)
Methyl	80.0 % (12 of 15)	80.0 % (12 of 15)

1. GS-alfa-Ktx5.4 SCORPION TOXIN

GSAFCNLRRC ELSCRSLGLL GKCIGEECKC VPY

Show sample condition

Sample

Solvent system 95% H2O/5% D2O, Pressure 1 atm, Temperature 297 K, pH 6.5, Details 2.3 MM GS-alfaKtx5.4 95% H2O/5% D2O

#	Name	Isotope labeling	Type	Concentration
1	GS-alfa-Ktx5.4 SCORPION TOXIN	natural abundance		1.8 mM
2	H2O	natural abundance		95 %
3	D2O	natural abundance		5 %

Hide sample codition

Protein Blocks Logo

Calculated from 17 models in PDB: 2KY3, Strand ID: A Detail

---

Release date

2015-06-18

Citation 1

Cytotoxicity of recombinant tamapin and related toxin-like peptides on model cell lines
Ramirez-Cordero, B.E., Toledano, Y., Cano-Sanchez, P., Hernandez-Lopez, R., Flores-Solis, D., Saucedo-Yanez, A.L., Chavez-Uribe, I., Brieba, L.G., Del Rio-Portilla, F.
Chem. Res. Toxicol. (2014), 27, 960-967, PubMed 24821061 , DOI 10.1021/tx4004193 , Abstract

Show more 1 citaion

Citation 2

Tamapin, a Venom Peptide from the Indian Red Scorpi (Mesobuthus Tamulus) Thet Targets Small Conductance Activated K+ Channels and Afterhyperpolarization Cu Central Neurons
Del Rio-Portilla, F., Ramirez-Cordero, B.E., Saucedo Yanez, L.BRIEBA., Cano-Sanchez, P., Flores-Solis, R.HERNANDEZ-LO., Pedarzani, P., Dhoedet, D., Doorty, K.B., Wadsworth, J.D.F., Jeyaseelan, J.K., Kini, R.M., Gadre, S.V., Sapatnekar, S.M., Strong, M.ST.
Journal of Biological Chemis

Hide non-primary 1 citaion

Related entities 1. GS-alfa-Ktx5.4 SCORPION TOXIN, : 1 : 13 : 24 entities Detail

Experiments performed 3 experiments Detail