BMRB: 17296

NMR solution structure of GLP-2 in 2,2,2 trifluroethanol

Authors

Venneti, K.C., Hewage, C.M.

Assembly

GLP-2

Entity

1. GLP-2 (polymer, Thiol state: not present), 33 monomers, 3766.109 Da Detail

HADGSFSDEM NTILDNLAAR DFINWLIQTK ITD

Formula weight

3766.109 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Refine. method

torsion angle dynamics

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 93.3 %, Completeness (bb): 98.5 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	93.3 % (180 of 193)	93.3 % (180 of 193)
Backbone	98.5 % (66 of 67)	98.5 % (66 of 67)
Sidechain	90.5 % (114 of 126)	90.5 % (114 of 126)
Aromatic	77.8 % (14 of 18)	77.8 % (14 of 18)
Methyl	85.0 % (17 of 20)	85.0 % (17 of 20)

1. GLP-2

HADGSFSDEM NTILDNLAAR DFINWLIQTK ITD

Show sample condition

Sample

Solvent system trifluoroethanol/water, Temperature 273 K, pH 3.9

#	Name	Isotope labeling	Type	Concentration
1	TFE	natural abundance		33 %
2	H2O	natural abundance		67 %

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Calculated from 10 models in PDB: 2L63, Strand ID: A Detail

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Release date

2011-03-29

Citation

Conformational and molecular interaction studies of glucagon-like peptide-2 with its N-terminal extracellular receptor domain
Venneti, K.C., Hewage, C.M.
FEBS Lett. (2011), 585, 346-352, PubMed 21167157 , DOI 10.1016/j.febslet.2010.12.011 , Abstract

Related entities 1. GLP-2, : 1 : 4 : 3 : 161 entities Detail

Interaction partners 1. GLP-2, : 4 interactors Detail

Experiments performed 2 experiments Detail