BMRB: 18972

SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU-CONOTOXIN CnVA

Authors

Petrel, C., Hocking, H.G., Reynaud, M., Favreau, P., Paolini-bertrand, M., Peigneur, S., Upert, G., Tytgat, J., Gilles, N., Hartley, O., Boelens, R., Stocklin, R., Servent, D., Servent, R.

Assembly

SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU-CONOTOXIN CnVA

Entity

1. SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU-CONOTOXIN CnVA (polymer, Thiol state: all disulfide bound), 15 monomers, 1721.124 Da Detail

ECCHRQLLCC LRFVX

Formula weight

1721.124 Da

Entity Connection

disulfide 2 Detail

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ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	1:CYS2:SG	1:CYS9:SG
2	disulfide	sing	1:CYS3:SG	1:CYS10:SG

Source organism

Conus consors

Exptl. method

solution NMR

Refine. method

CYANA

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 93.3 %, Completeness: 89.0 %, Completeness (bb): 78.6 % Detail

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Polymer type: polypeptide(L)

	Total	1H	13C
All	89.0 % (138 of 155)	97.8 % (87 of 89)	77.3 % (51 of 66)
Backbone	78.6 % (55 of 70)	96.4 % (27 of 28)	66.7 % (28 of 42)
Sidechain	98.0 % (97 of 99)	98.4 % (60 of 61)	97.4 % (37 of 38)
Aromatic	85.7 % (12 of 14)	85.7 % (6 of 7)	85.7 % (6 of 7)
Methyl	100.0 % (16 of 16)	100.0 % (8 of 8)	100.0 % (8 of 8)

1. TAU-CNVA

ECCHRQLLCC LRFVX

Show sample condition

Sample

Solvent system 95 % H2O/5%D2O, Pressure 1 atm, Temperature 295.000 K, pH 3.000, Details 2.3 mmol/l

#	Name	Isotope labeling	Type	Concentration
1	TAU-CNVA	[U-13C; U-15N]		2.3 mM

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Protein Blocks Logo

Calculated from 10 models in PDB: 3ZKT, Strand ID: A Detail

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Release date

2015-07-22

Citation

Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor
Petrel, C., Hocking, H.G., Reynaud, M., Favreau, P., Paolini-bertrand, M., Peigneur, S., Upert, G., Tytgat, J., Gilles, N., Hartley, O., Boelens, R., Stocklin, R., Servent, D.
Biochem. Pharmacol. (2013), 85, 1663-1671, PubMed 23567999 , DOI 10.1016/j.bcp.2013.03.019 , Abstract

Entries sharing articles Swiss-Prot: 7 entries Detail

Related entities 1. SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU-CONOTOXIN CnVA, : 1 : 1 entities Detail

Experiments performed 4 experiments Detail