BMRB: 19309

3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside

Authors

Monti, J., Richard, T.

Assembly

complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside

Entity

1. amyloid peptide (polymer, Thiol state: not present), 40 monomers, 4329.801 Da Detail

DAEFRHDSGY EVHHQKLVFF AEDVGSNKGA IIGLMVGGVV

2. furan-2-sulfonamide (non-polymer), 147.152 × 12 Da

Total weight

6095.625 Da

Max. entity weight

4329.801 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Refine. method

simulated annealing

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 97.3 %, Completeness (bb): 98.8 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	97.3 % (220 of 226)	97.3 % (220 of 226)
Backbone	98.8 % (85 of 86)	98.8 % (85 of 86)
Sidechain	96.4 % (135 of 140)	96.4 % (135 of 140)
Aromatic	88.0 % (22 of 25)	88.0 % (22 of 25)
Methyl	100.0 % (23 of 23)	100.0 % (23 of 23)

1. amyloid peptide

DAEFRHDSGY EVHHQKLVFF AEDVGSNKGA IIGLMVGGVV

Show sample condition

Sample

Solvent system DMSO, Pressure 1 atm, Temperature 300 K

#	Name	Isotope labeling	Type	Concentration
1	amyloid peptide	natural abundance		1 mM

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Protein Blocks Logo

Calculated from 12 models in PDB: 2M9R, Strand ID: A Detail

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Release date

2013-09-09

Citation

3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol ε-viniferin glucoside: implications in Alzheimer's disease
Richard, T., Papastamoulis, Y., Pierre, W., Monti, J.
Biochim. Biophys. Acta (2013), 1830, 5068-5074, PubMed 23830862 , DOI 10.1016/j.bbagen.2013.06.031 , Abstract

Related entities 1. amyloid peptide, : 1 : 90 : 5 : 7 : 17 entities Detail

Interaction partners 1. amyloid peptide, : 95 interactors Detail

Experiments performed 2 experiments Detail