BMRB: 19435

Structural studies on dinuclear ruthenium(II) complexes that bind diastereoselectively to an anti-parallel folded human telomere sequence

Authors

Williamson, M.P., Wilson, T., Thomas, J.A., Felix, V., Costa, P.J.

Assembly

Complex between DNA quadruplex (human telomere) and DD-bisRuthenium ligand

Entity

1. human telomere quadruplex (polymer), 22 monomers, 7046.467 Da Detail

AGGGTTAGGG TTAGGGTTAG GG

2. Complex between DNA quadruplex (human telomere) and DD-bisRuthenium ligand, entity RUL (non-polymer), 1211.268 Da

Total weight

8257.734 Da

Max. entity weight

7046.467 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 90.2 %, Completeness (bb): 93.5 % Detail

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Polymer type: polydeoxyribonucleotide

	Total	1H
All	90.2 % (184 of 204)	90.2 % (184 of 204)
Suger, PO4	93.5 % (144 of 154)	93.5 % (144 of 154)
Nucleobase	80.0 % (40 of 50)	80.0 % (40 of 50)
Aromatic	77.3 % (34 of 44)	77.3 % (34 of 44)
Methyl	100.0 % (6 of 6)	100.0 % (6 of 6)

1. human telomere quadruplex

AGGGTTAGGG TTAGGGTTAG GG

Show sample condition

Sample

Solvent system 100% D2O, Pressure 1 atm, Temperature 298 K, pH 7

#	Name	Isotope labeling	Type	Concentration
1	human telomere quadruplex	natural abundance		300 mM
2	LL-(Ru[bipy]2)tppz4+	natural abundance		300 mM
3	sodium chloride	natural abundance		50 mM

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Release date

2013-09-29

Citation

Structural studies on dinuclear ruthenium(II) complexes that bind diastereoselectively to an antiparallel folded human telomere sequence
Wilson, T., Costa, P.J., Felix, V., Williamson, M.P., Thomas, J.A.
J. Med. Chem. (2013), 56, 8674-8683, PubMed 24088028 , DOI 10.1021/jm401119b , Abstract

Related entities 1. human telomere quadruplex, : 1 : 1 entities Detail

Experiments performed 4 experiments Detail