BMRB: 25174

Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA

Authors

Chhabra, S., Robinson, S., Norton, R.

Assembly

Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA

Entity

1. Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA (polymer), 13 monomers, 1538.759 Da Detail

GXCSDPRXRY RCR

Formula weight

1538.759 Da

Source organism

Conus regius

Exptl. method

solution NMR

Refine. method

simulated annealing

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 84.6 %, Completeness: 78.6 %, Completeness (bb): 79.7 % Detail

Download

• NMR-STAR v3.1 (partial)
• BMRB/XML (partial)
• CSV
• TSV

Polymer type: polypeptide(L)

	Total	1H	13C	15N
All	78.6 % (99 of 126)	84.3 % (59 of 70)	67.4 % (31 of 46)	90.0 % (9 of 10)
Backbone	79.7 % (51 of 64)	95.5 % (21 of 22)	65.6 % (21 of 32)	90.0 % (9 of 10)
Sidechain	80.6 % (58 of 72)	79.2 % (38 of 48)	83.3 % (20 of 24)
Aromatic	100.0 % (8 of 8)	100.0 % (4 of 4)	100.0 % (4 of 4)

1. Alpha-conotoxin RgIA

GXCSDPRXRY RCR

Show sample condition

Sample

Solvent system 100% D2O, Pressure 1 atm, Temperature 298 K, pH 3.0

#	Name	Isotope labeling	Type	Concentration
1	cis-[2,8]-dicarba RgIA	natural abundance		500 uM
2	D2O	natural abundance		100 %

Hide sample codition

Protein Blocks Logo

Calculated from 20 models in PDB: 2MTO, Strand ID: A Detail

---

Release date

2016-09-27

Citation

Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets
chhabra, S., Belgi, A., Bartels, P., Robinson, S.D., Kompella, S.N., Hung, A., Callaghan, B.P., Adams, D.J., Robinson, A.J., Norton, R.S.
J. Med. Chem. (2014), 57, 9933-9944, PubMed 25393758 , DOI 10.1021/jm501126u , Abstract

Entries sharing articles BMRB: 2 entries Detail

Related entities 1. Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA, : 1 : 3 : 4 entities Detail

Experiments performed 6 experiments Detail