BMRB: 25475

Structure of Tau(267-312) bound to Microtubules

Authors

Kadavath, H., Jaremko, M., Jaremko, L., Zweckstetter, M.

Assembly

Tau(267-312) bound to Microtubules

Entity

1. Tau(267-312) bound to Microtubules (polymer), 46 monomers, 4882.599 Da Detail

KHQPGGGKVQ IINKKLDLSN VQSKCGSKDN IKHVPGGGSV QIVYKP

Formula weight

4882.599 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Refine. method

simulated annealing

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 93.5 %, Completeness: 15.0 %, Completeness (bb): 44.8 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	15.0 % (43 of 287)	15.0 % (43 of 287)
Backbone	44.8 % (43 of 96)	44.8 % (43 of 96)
Sidechain	0.0 % (0 of 191)	0.0 % (0 of 191)
Aromatic	0.0 % (0 of 8)	0.0 % (0 of 8)
Methyl	0.0 % (0 of 22)	0.0 % (0 of 22)

1. entity

KHQPGGGKVQ IINKKLDLSN VQSKCGSKDN IKHVPGGGSV QIVYKP

Show sample condition

Sample #1

Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 278 K, pH 6.8

#	Name	Isotope labeling	Type	Concentration
1	sodium phosphate	natural abundance		50 mM
2	entity	natural abundance		1 mM
3	H2O	natural abundance		90 %
4	D2O	natural abundance		10 %

Sample #2

Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 278 K, pH 6.8

#	Name	Isotope labeling	Type	Concentration
5	sodium phosphate	natural abundance		50 mM
6	entity	natural abundance		1 mM
7	microtubules	natural abundance		50 uM
8	H2O	natural abundance		90 %
9	D2O	natural abundance		10 %

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Protein Blocks Logo

Calculated from 20 models in PDB: 2MZ7, Strand ID: A Detail

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Release date

2015-07-12

Citation

Folding of the Tau Protein on Microtubules
Kadavath, H., Jaremko, M., Jaremko, L., Biernat, J., Mandelkow, E., Zweckstetter, M.
Angew. Chem Int Ed Engl. (2015), 54, 10347-10351, PubMed 26094605 , DOI 10.1002/anie.201501714 , Abstract

Related entities 1. Tau(267-312) bound to Microtubules, : 1 : 112 : 4 : 282 entities Detail

Interaction partners 1. Tau(267-312) bound to Microtubules, : 4 interactors Detail

Experiments performed 5 experiments Detail