BMRB: 25759

Solution structure for quercetin complexed with c-myc G-quadruplex DNA

Authors

Kumar, A., Tawani, A.

Assembly

Quercetin complexed with c-myc G-quadruplex DNA

Entity

1. DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*GP*(DN)P*(DN))-3') (polymer, Thiol state: not present), 26 monomers, 8115.096 Da Detail

TGAGGGTGGT GAGGGTGGGG AAGGXX

2. Quercetin complexed with c-myc G-quadruplex DNA, entity QUE (non-polymer), 302.236 Da

Total weight

8417.332 Da

Max. entity weight

8115.096 Da

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 84.6 %, Completeness: 25.0 %, Completeness (bb): 11.3 % Detail

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Polymer type: polydeoxyribonucleotide

	Total	1H
All	25.0 % (55 of 220)	25.0 % (55 of 220)
Suger, PO4	11.3 % (19 of 168)	11.3 % (19 of 168)
Nucleobase	69.2 % (36 of 52)	69.2 % (36 of 52)
Aromatic	72.9 % (35 of 48)	72.9 % (35 of 48)
Methyl	25.0 % (1 of 4)	25.0 % (1 of 4)

1. DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*GP*(DN)P*(DN))-3')

TGAGGGTGGT GAGGGTGGGG AAGGX

Show sample condition

Sample

Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 295 K, pH 7.1

#	Name	Isotope labeling	Type	Concentration
1	DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*GP*(DN)P*(DN))-3')	natural abundance	DNA	2.3 mM
2	H2O	natural abundance	solvent	90 %
3	D2O	[U-2H]	solvent	10 %

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Release date

2016-09-11

Citation

Solution structure for quercetin complexed with c-myc G-quadruplex DNA
Kumar, A., Tawani, A.
Not known

Experiments performed 1 experiments Detail