BMRB: 26032

Structural insights of r(CGG) motif found in Fragile X Syndrome and Fragile-X associated tremor/ataxia syndrome (FXTAS) at 45 degree C

Authors

Kumar, A., Mishra, S.KUMAR.

Assembly

r(CGG) motif

Entity

1. r(CGG) motif (polymer, Thiol state: not present), 9 monomers, 2964.771 × 2 Da Detail

CCGCGGCGG

Total weight

5929.542 Da

Max. entity weight

2964.771 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 23.7 %, Completeness (bb): 14.8 % Detail

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Polymer type: polyribonucleotide

	Total	1H
All	23.7 % (19 of 80)	23.7 % (19 of 80)
Suger, PO4	14.8 % (8 of 54)	14.8 % (8 of 54)
Nucleobase	42.3 % (11 of 26)	42.3 % (11 of 26)
Aromatic	61.1 % (11 of 18)	61.1 % (11 of 18)

1. RNA (5'-R(P*CP*CP*GP*CP*GP*GP*CP*GP*G)-3')

CCGCGGCGG

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Sample

Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 318 K, pH 7

#	Name	Isotope labeling	Type	Concentration
1	RNA (5'-R(P*CP*CP*GP*CP*GP*GP*CP*GP*G)-3')	natural abundance	RNA	1.5 mM
2	H2O	natural abundance	solvent	90 %
3	D2O	[U-2H]	solvent	10 %

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Release date

2016-04-17

Citation

Structural insights reveal the dynamics of the repeating r(CGG) motif found in Fragile X Syndrome and Fragile-X associated tremor/ataxia syndrome (FXTAS)
Mishra, S.KUMAR., Kumar, A.
Not known

Experiments performed 1 experiments Detail