BMRB: 30076

Domain 4 Segment 6 of voltage-gated sodium channel Nav1.4

Authors

Niitsu, A., Egawa, A., Ikeda, K., Tachibana, K., Fujiwara, T.

Assembly

Sodium channel protein type 4 subunit alpha

Entity

1. Sodium channel protein type 4 subunit alpha (polymer), 35 monomers, 4027.020 Da Detail

KKKGICFFCS YIIISFLIVV NMYIAIILEN FKKKX

Formula weight

4027.02 Da

Source organism

Rattus norvegicus

Exptl. method

NMR

Refine. method

molecular dynamics

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 51.4 %, Completeness: 58.2 %, Completeness (bb): 52.5 % Detail

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Polymer type: polypeptide(L)

	Total	13C
All	58.2 % (107 of 184)	58.2 % (107 of 184)
Backbone	52.5 % (53 of 101)	52.5 % (53 of 101)
Sidechain	61.2 % (71 of 116)	61.2 % (71 of 116)
Aromatic	71.4 % (20 of 28)	71.4 % (20 of 28)
Methyl	100.0 % (25 of 25)	100.0 % (25 of 25)

1. Sodium channel protein type 4 subunit alpha

KKKGICFFCS YIIISFLIVV NMYIAIILEN FKKKX

Show sample condition

Sample #1

Solvent system water, Pressure 1 atm, Temperature 213 K, pH 7.4, Details 16 % U-13C I23, L17, V20 peptide, 69 % d-54 DMPC, water

#	Name	Isotope labeling	Type	Concentration
1	DMPC	d-54		69 %
2	peptide	U-13C I23, L17, V20		16 %

Sample #2

Solvent system water, Pressure 1 atm, Temperature 213 K, pH 7.4, Details 16 % U-13C G, I, F, L, V, A peptide, 69 % d-54 DMPC, water

#	Name	Isotope labeling	Type	Concentration
3	DMPC	d-54		69 %
4	peptide	U-13C G, I, F, L, V, A		16 %

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Calculated from 10 models in PDB: 5JR0, Strand ID: A Detail

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Release date

2016-05-25

Citation

Veratridine binding to a transmembrane helix of sodium channel Na_v1.4 determined by solid-state NMR
Niitsu, A., Egawa, A., Ikeda, K., Tachibana, K., Fujiwara, T.
Bioorg. Med. Chem. (2018), 26, 5644-5653, PubMed 30389410 , DOI 10.1016/j.bmc.2018.10.012 , Abstract

Related entities 1. Sodium channel protein type 4 subunit alpha, : 1 : 183 entities Detail

Experiments performed 3 experiments Detail