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BMRB: 30121

5KK3

Atomic Resolution Structure of Monomorphic AB42 Amyloid Fibrils

Authors

Colvin, M.T., Silvers, R., Zhe Ni, Q., Can, T.V., Sergeyev, I., Rosay, M., Donovan, K.J., Michael, B., Wall, J., Linse, S., Griffin, R.G.

Assembly

Beta-amyloid protein 42

Entity

1. Beta-amyloid protein 42 (polymer, Thiol state: not present), 42 monomers, 4514.037 × 18 Da Detail

DAEFRHDSGY EVHHQKLVFF AEDVGSNKGA IIGLMVGGVV IA

Total weight

81252.67 Da

Max. entity weight

4514.037 Da

Source organism

Homo sapiens

Exptl. method

NMR

Refine. method

torsion angle dynamics

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 69.0 %, Completeness: 64.8 %, Completeness (bb): 67.3 % Detail

Polymer type: polypeptide(L)

	Total	¹³C	¹⁵N
All	64.8 % (149 of 230)	64.5 % (120 of 186)	65.9 % (29 of 44)
Backbone	67.3 % (109 of 162)	67.5 % (81 of 120)	66.7 % (28 of 42)
Sidechain	61.5 % (64 of 104)	61.8 % (63 of 102)	50.0 % (1 of 2)
Aromatic	24.0 % (6 of 25)	24.0 % (6 of 25)
Methyl	84.6 % (22 of 26)	84.6 % (22 of 26)

1. entity 1

DAEFRHDSGY EVHHQKLVFF AEDVGSNKGA IIGLMVGGVV IA

Show sample condition

Sample #1

Solvent system 100% H2O, Pressure 1 atm, Temperature 277 K, pH 8.0, Details 1 mg/uL [U-100% 13C; U-100% 15N] AB42-M01-42, 20 mM sodium phosphate, 0.2 mM EDTA, 0.02 % sodium azide, 100% H2O

#	Name	Isotope labeling	Concentration
1	AB42-M01-42	[U-100% 13C; U-100% 15N]	1 g/L
2	EDTA	natural abundance	0.2 mM
3	sodium azide	natural abundance	0.02 %
4	sodium phosphate	natural abundance	20 mM

Sample #2

Solvent system 100% H2O, Pressure 1 atm, Temperature 277 K, pH 8.0, Details 1 mg/uL [U-30% 13C; U-30% 15N] AB42-M01-42, 20 mM sodium phosphate, 0.2 mM EDTA, 0.02 % sodium azide, 100% H2O

#	Name	Isotope labeling	Concentration
5	AB42-M01-42	[U-30% 13C; U-30% 15N]	1 g/L
6	EDTA	natural abundance	0.2 mM
7	sodium azide	natural abundance	0.02 %
8	sodium phosphate	natural abundance	20 mM

Sample #3

Solvent system 100% H2O, Pressure 1 atm, Temperature 277 K, pH 8.0, Details 1 mg/uL [1,6-13C-glucose, U-100% 15N] AB42-M01-42, 20 mM sodium phosphate, 0.2 mM EDTA, 0.02 % sodium azide, 100% H2O

#	Name	Isotope labeling	Concentration
9	AB42-M01-42	[1,6-13C-glucose, U-100% 15N]	1 g/L
10	EDTA	natural abundance	0.2 mM
11	sodium azide	natural abundance	0.02 %
12	sodium phosphate	natural abundance	20 mM

Sample #4

Solvent system 100% H2O, Pressure 1 atm, Temperature 277 K, pH 8.0, Details 1 mg/uL [2-13C-glycerol, U-100% 15N] AB42-M01-42, 20 mM sodium phosphate, 0.2 mM EDTA, 0.02 % sodium azide, 100% H2O

#	Name	Isotope labeling	Concentration
13	AB42-M01-42	[2-13C-glycerol, U-100% 15N]	1 g/L
14	EDTA	natural abundance	0.2 mM
15	sodium azide	natural abundance	0.02 %
16	sodium phosphate	natural abundance	20 mM

Protein Blocks Logo

Calculated from 10 models in PDB: 5KK3, Strand ID: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R Detail

Release date

2016-07-10

Citation 1

High resolution structural characterization of Aβ42 amyloid fibrils by magic angle spinning NMR
Colvin, M.T., Silvers, R., Frohm, B., Su, Y., Linse, S., Griffin, R.G.
J. Am. Chem. Soc. (2015), 137, 7509-7518, PubMed 26001057 , DOI 10.1021/jacs.5b03997 , Abstract

Show more 1 citaion

Citation 2

Atomic Resolution Structure of Monomorphic Aβ₄₂ Amyloid Fibrils
Colvin, M.T., Silvers, R., Ni, Q.Z., Can, T.V., Sergeyev, I.V., Rosay, M., Donovan, K.J., Michael, B., Wall, J.S., Linse, S., Griffin, R.G., Colvin, M.T., Silvers, R., Frohm, B., Su, Y., Linse, S., Griffin, R.G.
J. Am. Chem. Soc. (2016), 138, 9663-9674, PubMed 27355699 , DOI 10.1021/jacs.6b05129 , Abstract

Hide non-primary 1 citaion

Related entities 1. Beta-amyloid protein 42, : 1 : 44 : 3 : 54 : 17 entities Detail

Interaction partners 1. Beta-amyloid protein 42, : 96 interactors Detail

More details for 96 interactors identified by 55 citations

Experiments performed 16 experiments Detail

1 PAR 5 ms mixing

Instrument

Bruker AvanceIII - 800 MHz

Sample

State isotropic, Solvent system 100% H2O, Pressure 1 atm, Temperature 277 K, pH 8.0, Details 1 mg/uL [U-100% 13C; U-100% 15N] AB42-M01-42, 20 mM sodium phosphate, 0.2 mM EDTA, 0.02 % sodium azide, 100% H2O

#	Name	Isotope labeling	Concentration
1	AB42-M01-42	[U-100% 13C; U-100% 15N]	1 g/L
2	EDTA	natural abundance	0.2 mM
3	sodium azide	natural abundance	0.02 %
4	sodium phosphate	natural abundance	20 mM

2 PAR 10 ms mixing

Instrument

Bruker AvanceIII - 800 MHz

Sample

#	Name	Isotope labeling	Concentration
1	AB42-M01-42	[U-100% 13C; U-100% 15N]	1 g/L
2	EDTA	natural abundance	0.2 mM
3	sodium azide	natural abundance	0.02 %
4	sodium phosphate	natural abundance	20 mM

3 PAR 20 ms mixing

Instrument

Bruker AvanceIII - 800 MHz

Sample

#	Name	Isotope labeling	Concentration
1	AB42-M01-42	[U-100% 13C; U-100% 15N]	1 g/L
2	EDTA	natural abundance	0.2 mM
3	sodium azide	natural abundance	0.02 %
4	sodium phosphate	natural abundance	20 mM

4 PAIN 30 ms mixing

Instrument

Home-built RUBEN750 - 750 MHz

Sample

#	Name	Isotope labeling	Concentration
1	AB42-M01-42	[U-100% 13C; U-100% 15N]	1 g/L
2	EDTA	natural abundance	0.2 mM
3	sodium azide	natural abundance	0.02 %
4	sodium phosphate	natural abundance	20 mM

5 DARR 25 ms mixing

Instrument

Bruker AvanceIII - 800 MHz

Sample

#	Name	Isotope labeling	Concentration
1	AB42-M01-42	[U-100% 13C; U-100% 15N]	1 g/L
2	EDTA	natural abundance	0.2 mM
3	sodium azide	natural abundance	0.02 %
4	sodium phosphate	natural abundance	20 mM

6 DARR 100 ms mixing

Instrument

Bruker AvanceIII - 800 MHz

Sample

State isotropic, Solvent system 100% H2O, Pressure 1 atm, Temperature 277 K, pH 8.0, Details 1 mg/uL [U-30% 13C; U-30% 15N] AB42-M01-42, 20 mM sodium phosphate, 0.2 mM EDTA, 0.02 % sodium azide, 100% H2O

#	Name	Isotope labeling	Concentration
5	AB42-M01-42	[U-30% 13C; U-30% 15N]	1 g/L
6	EDTA	natural abundance	0.2 mM
7	sodium azide	natural abundance	0.02 %
8	sodium phosphate	natural abundance	20 mM

7 ZF-TEDOR 6.4 ms mixing

Instrument

Bruker AvanceIII - 800 MHz

Sample

State isotropic, Solvent system 100% H2O, Pressure 1 atm, Temperature 277 K, pH 8.0, Details 1 mg/uL [1,6-13C-glucose, U-100% 15N] AB42-M01-42, 20 mM sodium phosphate, 0.2 mM EDTA, 0.02 % sodium azide, 100% H2O

#	Name	Isotope labeling	Concentration
9	AB42-M01-42	[1,6-13C-glucose, U-100% 15N]	1 g/L
10	EDTA	natural abundance	0.2 mM
11	sodium azide	natural abundance	0.02 %
12	sodium phosphate	natural abundance	20 mM

8 FS-REDOR

Instrument

Home-built RUBEN750 - 750 MHz

Sample

#	Name	Isotope labeling	Concentration
5	AB42-M01-42	[U-30% 13C; U-30% 15N]	1 g/L
6	EDTA	natural abundance	0.2 mM
7	sodium azide	natural abundance	0.02 %
8	sodium phosphate	natural abundance	20 mM

9 FS-REDOR

Instrument

Home-built RUBEN750 - 750 MHz

Sample

#	Name	Isotope labeling	Concentration
1	AB42-M01-42	[U-100% 13C; U-100% 15N]	1 g/L
2	EDTA	natural abundance	0.2 mM
3	sodium azide	natural abundance	0.02 %
4	sodium phosphate	natural abundance	20 mM

10 PAR 20 ms mixing

Instrument

Bruker AvanceIII - 800 MHz

Sample

#	Name	Isotope labeling	Concentration
5	AB42-M01-42	[U-30% 13C; U-30% 15N]	1 g/L
6	EDTA	natural abundance	0.2 mM
7	sodium azide	natural abundance	0.02 %
8	sodium phosphate	natural abundance	20 mM

11 DARR 400 ms mixing

Instrument

Home-built RUBEN750 - 750 MHz

Sample

State isotropic, Solvent system 100% H2O, Pressure 1 atm, Temperature 277 K, pH 8.0, Details 1 mg/uL [2-13C-glycerol, U-100% 15N] AB42-M01-42, 20 mM sodium phosphate, 0.2 mM EDTA, 0.02 % sodium azide, 100% H2O

#	Name	Isotope labeling	Concentration
13	AB42-M01-42	[2-13C-glycerol, U-100% 15N]	1 g/L
14	EDTA	natural abundance	0.2 mM
15	sodium azide	natural abundance	0.02 %
16	sodium phosphate	natural abundance	20 mM

12 DARR 100 ms mixing

Instrument

Bruker AvanceIII - 800 MHz

Sample

#	Name	Isotope labeling	Concentration
9	AB42-M01-42	[1,6-13C-glucose, U-100% 15N]	1 g/L
10	EDTA	natural abundance	0.2 mM
11	sodium azide	natural abundance	0.02 %
12	sodium phosphate	natural abundance	20 mM

13 ZF-TEDOR 12 ms mixing

Instrument

Bruker AvanceIII - 800 MHz

Sample

#	Name	Isotope labeling	Concentration
9	AB42-M01-42	[1,6-13C-glucose, U-100% 15N]	1 g/L
10	EDTA	natural abundance	0.2 mM
11	sodium azide	natural abundance	0.02 %
12	sodium phosphate	natural abundance	20 mM

14 3D CONCA

Instrument

Home-built RUBEN750 - 750 MHz

Sample

#	Name	Isotope labeling	Concentration
1	AB42-M01-42	[U-100% 13C; U-100% 15N]	1 g/L
2	EDTA	natural abundance	0.2 mM
3	sodium azide	natural abundance	0.02 %
4	sodium phosphate	natural abundance	20 mM

15 3D NCOCX

Instrument

Home-built RUBEN750 - 750 MHz

Sample

#	Name	Isotope labeling	Concentration
1	AB42-M01-42	[U-100% 13C; U-100% 15N]	1 g/L
2	EDTA	natural abundance	0.2 mM
3	sodium azide	natural abundance	0.02 %
4	sodium phosphate	natural abundance	20 mM

16 3D NCACX

Instrument

Bruker AvanceIII - 800 MHz

Sample

#	Name	Isotope labeling	Concentration
1	AB42-M01-42	[U-100% 13C; U-100% 15N]	1 g/L
2	EDTA	natural abundance	0.2 mM
3	sodium azide	natural abundance	0.02 %
4	sodium phosphate	natural abundance	20 mM

NMR combined restraints 4 contents Detail

Properties

Input source #1: NMR data (NEF) - Assigned chemical shifts, Distance restraints, Dihedral angle restraints	combined_30121_5kk3.nef
Input source #2: Coordindates	5kk3.cif
Diamagnetism of the molecular assembly	True (excluding Oxygen atoms)
Whether the assembly has a disulfide bond	None
Whether the assembly has a other bond	None
Whether the assembly contains a cyclic polymer	None
Overall data processing status	Warning

Disulfide bonds

None

Other bonds (neither disulfide, covalent nor hydrogen bonds, e.g. Zinc–sulphur bond)

None

Non-standard residues

None

Sequence alignments

Entity_assembly_ID (NMR): A vs Auth_asym_ID (model): A

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): B vs Auth_asym_ID (model): B

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): C vs Auth_asym_ID (model): C

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): D vs Auth_asym_ID (model): D

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): E vs Auth_asym_ID (model): E

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): F vs Auth_asym_ID (model): F

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): G vs Auth_asym_ID (model): G

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): H vs Auth_asym_ID (model): H

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): I vs Auth_asym_ID (model): I

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): J vs Auth_asym_ID (model): J

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): K vs Auth_asym_ID (model): K

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): L vs Auth_asym_ID (model): L

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): M vs Auth_asym_ID (model): M

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): A vs Auth_asym_ID (model): A

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): A vs Auth_asym_ID (model): A

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): A vs Auth_asym_ID (model): A

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): A vs Auth_asym_ID (model): A

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Entity_assembly_ID (NMR): A vs Auth_asym_ID (model): A

--------10--------20--------30--------40--
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
||||||||||||||||||||||||||||||||||||||||||
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Chain assignments

Entity_assembly_ID (NMR)	Auth_asym_ID (model)	Length	Sequence coverage (%)
A	A	42	100.0
B	B	42	100.0
C	C	42	100.0
D	D	42	100.0
E	E	42	100.0
F	F	42	100.0
G	G	42	100.0
H	H	42	100.0
I	I	42	100.0
J	J	42	100.0
K	K	42	100.0
L	L	42	100.0
M	M	42	100.0
A	A	42	100.0
A	A	42	100.0
A	A	42	100.0
A	A	42	100.0
A	A	42	100.0

Content subtype: combined_30121_5kk3.nef

#	Content subtype	Saveframe	Status	# of rows (sets)	Experiment type	Sequence coverage (%)
1	Assigned chemical shifts	assigned_chemical_shifts_1	Warning	152		66.7 (chain: A, length: 42)
1	Distance restraints	DYANA/DIANA_distance_constraints_4	Warning	514 (1)	undefined	66.7 (chain: A, length: 42), 11.9 (chain: K, length: 42)
1	Dihedral angle restraints	DYANA/DIANA_dihedral_3	OK	27 (27)	.	47.6 (chain: A, length: 42)

Assigned chemical shifts

Saveframe: assigned_chemical_shifts_1
- Status: Warning
- Sequence coverage of experimental data
  - Entity_assembly_ID: A, Chain length: 42, Sequence coverage: 66.7%
- Total number of assignments
  - ¹³C chemical shifts: 123
  - ¹⁵N chemical shifts: 29
- Completeness of assignments
  - Entity_assemble_ID: A
- Rotameric state of ILE , LEU, and VAL
- Histogram of normalized assigned chemical shifts
- Random coil index and derived parameters (S² and NMR RMSD)
  - Chain_ID: A

Comp_index_ID	Comp_ID	Atom_ID	CS value (ppm)
15	GLN	CD	178.727
19	PHE	CG	138.325
20	PHE	CG	140.987
22	GLU	CD	183.776
23	ASP	CG	179.94
28	LYS	NZ	33.326

Atom group	# of target shifts	# of assigned shifts	Completeness (%)
¹³C chemical shifts	186	118	63.4
¹⁵N chemical shifts	45	28	62.2

Atom group	# of target shifts	# of assigned shifts	Completeness (%)
¹³C chemical shifts	84	56	66.7
¹⁵N chemical shifts	42	27	64.3

Atom group	# of target shifts	# of assigned shifts	Completeness (%)
¹³C chemical shifts	102	62	60.8
¹⁵N chemical shifts	3	1	33.3

Atom group	# of target shifts	# of assigned shifts	Completeness (%)
¹³C chemical shifts	27	23	85.2

Atom group	# of target shifts	# of assigned shifts	Completeness (%)
¹³C chemical shifts	25	6	24.0

Distance restraints

Saveframe: DYANA/DIANA_distance_constraints_4
- Status: Warning
- Experiment type: undefined
- Sequence coverage of experimental data
  - Entity_assembly_ID: A, Chain length: 42, Sequence coverage: 66.7%
  - Entity_assembly_ID: K, Chain length: 42, Sequence coverage: 11.9%
- Total number of restraints: 514
- Weight of restraints: 1.0 (514)
- Potential type of restraints: upper-bound-parabolic (514)
- Range of distance target values: 4.7, 12.0 (Å)
- Histogram of distance target values
- Distance restraints per residue
  - Chain_ID: A
  - Chain_ID: B
    None
  - Chain_ID: C
    None
  - Chain_ID: D
    None
  - Chain_ID: E
    None
  - Chain_ID: F
    None
  - Chain_ID: G
    None
  - Chain_ID: H
    None
  - Chain_ID: I
    None
  - Chain_ID: J
    None
  - Chain_ID: K
  - Chain_ID: L
    None
  - Chain_ID: M
    None
  - Chain_ID: N
    None
  - Chain_ID: O
    None
  - Chain_ID: P
    None
  - Chain_ID: Q
    None
  - Chain_ID: R
    None
- Distance restraints on contact map

Dihedral angle restraints

Saveframe: DYANA/DIANA_dihedral_3
- Status: OK
- Experiment type: .
- Sequence coverage of experimental data
  - Entity_assembly_ID: A, Chain length: 42, Sequence coverage: 47.6%
- Total number of restraints: 27
- Total number of restraints per polymer type: 27
- Weight of restraints: 1.0 (27)
- Potential type of restraints: square-well-parabolic (27)
- Plot of Phi-Psi angle restraints
- Dihedral angle restraints per residue

Keywords PROTEIN FIBRIL, amyloid beta, fibril

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Found 1 Document (2.705 seconds)

BMRB: 30121

Sample #1

Sample #2

Sample #3

Sample #4

Related entities 1. Beta-amyloid protein 42, : 1 : 44 : 3 : 54 : 17 entities Detail

Interaction partners 1. Beta-amyloid protein 42, : 96 interactors Detail

Experiments performed 16 experiments Detail

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NMR combined restraints 4 contents Detail