BMRB: 30509

HS02 - Intragenic antimicrobial peptides derived from the protein unconventional myosin 1h

Authors

Santos, M.A., Brand, G.D., Oliveira, A.L.

Assembly

Unconventional myosin-Ih peptide

Entity

1. Unconventional myosin-Ih peptide (polymer, Thiol state: not present), 16 monomers, 1962.428 Da Detail

KWAVRIIRKF IKGFIS

Formula weight

1962.428 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Refine. method

distance geometry

Data set

assigned_chemical_shifts, spectral_peak_list

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 84.0 %, Completeness (bb): 90.9 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	84.0 % (100 of 119)	84.0 % (100 of 119)
Backbone	90.9 % (30 of 33)	90.9 % (30 of 33)
Sidechain	81.4 % (70 of 86)	81.4 % (70 of 86)
Aromatic	62.5 % (10 of 16)	62.5 % (10 of 16)
Methyl	100.0 % (11 of 11)	100.0 % (11 of 11)

1. entity 1

KWAVRIIRKF IKGFIS

Show sample condition

Sample

Solvent system 90% H2O/10% D2O, Pressure 1 (±0.01) atm, Temperature 298 (±0.2) K, pH 7.4 (±0.05), Details 2 uM peptide, 50 uM D-98% Dodecylphosphorylcholine-d38, 10 mM PBS, 90% H2O/10% D2O

#	Name	Isotope labeling	Type	Concentration
1	peptide	natural abundance		2 (±0.2) uM
2	Dodecylphosphorylcholine-d38	D-98%		50 (±0.2) uM
3	PBS	natural abundance		10 (±0.2) mM

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Protein Blocks Logo

Calculated from 10 models in PDB: 6MBM, Strand ID: A Detail

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Release date

2018-09-13

Citation

Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity
Brand, G.D., Ramada, M., Manickchand, J.R., Correa, R., Ribeiro, D., Santos, M.A., Vasconcelos, A.G., Abrao, F.Y., Prates, M.V., Murad, A.M., Cardozo Fh, J.L., Leite, J., Magalhaes, K.G., Oliveira, A.L., Bloch, C.
PLoS One (2019), 14, e0220656-e0220656, PubMed 31386688 , DOI 10.1371/journal.pone.0220656 , Abstract

Related entities 1. Unconventional myosin-Ih peptide, : 1 : 2 : 3 : 13 entities Detail

Experiments performed 2 experiments Detail

Chemical shift validation 3 contents Detail