BMRB: 30586

Syn-safencin

Authors

Fields, F.R., Lee, S.W.

Assembly

Circular bacteriocin, circularin A/uberolysin family

Entity

1. Circular bacteriocin, circularin A/uberolysin family (polymer, Thiol state: not present), 25 monomers, 2929.462 Da Detail

AGKETIRQYL KNEIKKKGRK AVIAW

Formula weight

2929.462 Da

Source organism

Bacillus safensis

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 42.5 %, Completeness (bb): 98.1 % Detail

Download

• NMR-STAR v3.1 (partial)
• BMRB/XML (partial)
• CSV
• TSV

Polymer type: polypeptide(L)

	Total	1H
All	42.5 % (74 of 174)	42.5 % (74 of 174)
Backbone	98.1 % (51 of 52)	98.1 % (51 of 52)
Sidechain	18.9 % (23 of 122)	18.9 % (23 of 122)
Aromatic	0.0 % (0 of 10)	0.0 % (0 of 10)
Methyl	21.4 % (3 of 14)	21.4 % (3 of 14)

1. entity 1

AGKETIRQYL KNEIKKKGRK AVIAW

Show sample condition

Sample

Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 298 K, pH 7, Details 500 uM 1H Syn-safencin, 90% H2O/10% D2O

#	Name	Isotope labeling	Type	Concentration
1	Syn-safencin	1H		500 uM

Hide sample codition

Release date

2020-04-08

Citation

Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy
Fields, F.R., Manzo, G., Hind, C.K., Janardhanan, J., Foik, I.P., Carmo Silva, P.D., Balsara, R.D., Clifford, M., Vu, H.M., Ross, J.N., Kalwajtys, V.R., Gonzalez, A.J., Bui, T.T., Ploplis, V.A., Castellino, F.J., Siryaporn, A., Chang, M., Sutton, J.M., Mason, A.J., Lee, S.
ACS Pharmacol. Transl. Sci. (2020), 3, 418-424, PubMed 32566907 , DOI 10.1021/acsptsci.0c00001 , Abstract

Related entities 1. Circular bacteriocin, circularin A/uberolysin family, : 1 : 13 entities Detail

Experiments performed 2 experiments Detail

Chemical shift validation 3 contents Detail