BMRB: 30588

Syn-safencin 56

Authors

Fields, F.R., Lee, S.W.

Assembly

Circular bacteriocin, circularin A/uberolysin family

Entity

1. Circular bacteriocin, circularin A/uberolysin family (polymer, Thiol state: not present), 25 monomers, 3050.729 Da Detail

AGKEKIRKKL KNEIKKKWRK AVIAW

Formula weight

3050.729 Da

Source organism

Bacillus safensis

Exptl. method

solution NMR

Refine. method

simulated annealing

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 37.2 %, Completeness (bb): 96.1 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	37.2 % (71 of 191)	37.2 % (71 of 191)
Backbone	96.1 % (49 of 51)	96.1 % (49 of 51)
Sidechain	15.7 % (22 of 140)	15.7 % (22 of 140)
Aromatic	0.0 % (0 of 12)	0.0 % (0 of 12)
Methyl	15.4 % (2 of 13)	15.4 % (2 of 13)

1. entity 1

AGKEKIRKKL KNEIKKKWRK AVIAW

Show sample condition

Sample

Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 298 K, pH 7, Details 500 uM Syn-safencin 56, 90% H2O/10% D2O

#	Name	Isotope labeling	Type	Concentration
1	Syn-safencin 56	natural abundance		500 uM

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Protein Blocks Logo

Calculated from 10 models in PDB: 6O8S, Strand ID: X Detail

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Release date

2020-05-05

Citation

Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy
Fields, F.R., Manzo, G., Hind, C.K., Janardhanan, J., Foik, I.P., Carmo Silva, P.D., Balsara, R.D., Clifford, M., Vu, H.M., Ross, J.N., Kalwajtys, V.R., Gonzalez, A.J., Bui, T.T., Ploplis, V.A., Castellino, F.J., Siryaporn, A., Chang, M., Sutton, J.M., Mason, A.J., Lee, S.
ACS Pharmacol. Transl. Sci. (2020), 3, 418-424, PubMed 32566907 , DOI 10.1021/acsptsci.0c00001 , Abstract

Related entities 1. Circular bacteriocin, circularin A/uberolysin family, : 1 : 2 : 3 entities Detail

Experiments performed 2 experiments Detail

Chemical shift validation 3 contents Detail