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Structure of the C-terminal Domain of RAGE and Its Inhibitor
Authors
Ramirez, L., Shekhtman, A.
Assembly
Advanced glycosylation end product-specific receptor
Entity
1. Advanced glycosylation end product-specific receptor, entity 1 (polymer, Thiol state: not present), 43 monomers, 5028.185 Da Detail

MWQRRQRRGE ERKAPENQEE EEERAELNQS EEPEAGESST GGP


2. Advanced glycosylation end product-specific receptor, entity RQV (non-polymer), 386.446 Da
Total weight
5414.631 Da
Max. entity weight
5028.185 Da
Source organism
Homo sapiens
Exptl. method
solution NMR
Refine. method
simulated annealing
Data set
assigned_chemical_shifts, spectral_peak_list
Chemcal Shifts
1H: 231, 13C: 112, 15N: 40 assignments Detail
IDEntity IDSeq IDComp IDAtom IDAtom typeValVal errAmbig. code
111METHH8.2750.0201
211METHAH4.1800.0201
311METHB2H1.8980.0202
411METHB3H1.7270.0202
511METHG2H2.1270.0201
611METHG3H2.1270.0201
711METCAC51.3700.31
811METCBC26.4640.31
911METNN123.1240.31
1012TRPHH8.6830.0201
1112TRPCAC54.5320.31
1212TRPCBC26.6150.31
1312TRPNN124.7240.31
1413GLNHH8.1500.0201
1513GLNHAH4.0650.0201
1613GLNHB2H1.7940.0202
1713GLNHB3H1.6800.0202
1813GLNHG2H2.0620.0201
1913GLNHG3H2.0620.0201
2013GLNCAC52.4730.31
2113GLNCBC26.9930.31
2213GLNCGC30.7830.31
2313GLNNN123.2380.31
2414ARGHH8.1160.0201
2514ARGHAH3.9440.0201
2614ARGHB2H1.6110.0202
2714ARGHB3H1.5090.0202
2814ARGHG2H1.4160.0201
2914ARGHG3H1.4160.0201
3014ARGHD2H3.0370.0201
3114ARGHD3H3.0370.0201
3214ARGCAC53.5430.31
3314ARGCBC27.5990.31
3414ARGCGC27.1900.31
3514ARGCDC40.1560.31
3614ARGNN122.4260.31
3715ARGHH8.3860.0201
3815ARGHAH4.1110.0201
3915ARGHB2H1.6440.0201
4015ARGHB3H1.6440.0201
4115ARGHG2H1.4620.0201
4215ARGHG3H1.4620.0201
4315ARGHD2H3.0210.0201
4415ARGHD3H3.0210.0201
4515ARGCAC53.4460.31
4615ARGCBC27.9010.31
4715ARGCGC27.5030.31
4815ARGCDC40.0780.31
4915ARGNN122.4540.31
5016GLNHH8.3800.0201
5116GLNHAH4.1860.0201
5216GLNHB2H1.8180.0201
5316GLNHB3H1.8180.0201
5416GLNHG2H2.2040.0201
5516GLNHG3H2.2040.0201
5616GLNCAC53.1210.31
5716GLNCBC26.6910.31
5816GLNCGC33.5170.31
5916GLNNN121.8820.31
6017ARGHH8.4360.0201
6117ARGHAH4.1860.0201
6217ARGHB2H1.6580.0202
6317ARGHB3H1.5930.0202
6417ARGHG2H1.4810.0201
6517ARGHG3H1.4810.0201
6617ARGHD2H3.0370.0201
6717ARGHD3H3.0370.0201
6817ARGCAC53.1210.31
6917ARGCBC27.8260.31
7017ARGCGC27.1120.31
7117ARGCDC40.0780.31
7217ARGNN123.1400.31
7318ARGHH8.5050.0201
7418ARGHAH4.1710.0201
7518ARGHB2H1.7230.0202
7618ARGHB3H1.6210.0202
7718ARGHG2H1.5090.0201
7818ARGHG3H1.5090.0201
7918ARGHD2H3.0370.0201
8018ARGHD3H3.0370.0201
8118ARGCAC53.4780.31
8218ARGCBC27.8260.31
8318ARGCGC27.2680.31
8418ARGCDC40.2340.31
8518ARGNN122.8560.31
8619GLYHH8.5320.0201
8719GLYHA2H3.8080.0201
8819GLYHA3H3.8080.0201
8919GLYCAC42.7120.31
9019GLYNN110.8250.31
91110GLUHH8.1950.0201
92110GLUHAH4.1560.0201
93110GLUHB2H1.9620.0202
94110GLUHB3H1.7800.0202
95110GLUHG2H2.1090.0201
96110GLUHG3H2.1090.0201
97110GLUCAC53.6400.31
98110GLUCBC27.2960.31
99110GLUCGC33.4390.31
100110GLUNN120.2720.31
101111GLUHH8.2610.0201
102111GLUHAH4.1260.0201
103111GLUHB2H1.9010.0202
104111GLUHB3H1.7800.0202
105111GLUHG2H2.1430.0201
106111GLUHG3H2.1430.0201
107111GLUCAC53.9320.31
108111GLUCBC26.8420.31
109111GLUCGC33.5170.31
110111GLUNN121.0490.31
111112ARGHH8.2500.0201
112112ARGHAH4.1860.0201
113112ARGHB2H1.7230.0202
114112ARGHB3H1.6300.0202
115112ARGHG2H1.4620.0201
116112ARGHG3H1.4620.0201
117112ARGHD2H3.0270.0201
118112ARGHD3H3.0270.0201
119112ARGCAC53.0890.31
120112ARGCBC27.3720.31
121112ARGCGC27.3720.31
122112ARGCDC40.0000.31
123112ARGNN122.0190.31
124113LYSHH8.2610.0201
125113LYSHAH4.3980.0201
126113LYSHB2H1.7040.0201
127113LYSHB3H1.7040.0201
128113LYSHG2H1.2810.0201
129113LYSHG3H1.2810.0201
130113LYSHD2H1.5650.0201
131113LYSHD3H1.5650.0201
132113LYSHE2H2.8550.0201
133113LYSHE3H2.8550.0201
134113LYSCAC53.1210.31
135113LYSCBC30.0950.31
136113LYSCGC21.8010.31
137113LYSCDC25.7060.31
138113LYSCEC39.2190.31
139113LYSNN122.9740.31
140114ALAHH8.2680.0201
141114ALAHAH4.4610.0201
142114ALAHB1H1.2650.0201
143114ALAHB2H1.2650.0201
144114ALAHB3H1.2650.0201
145114ALACAC47.7710.31
146114ALACBC15.3150.31
147114ALANN126.5900.31
148116GLUHH8.6040.0201
149116GLUHAH4.0650.0201
150116GLUHB2H1.9160.0202
151116GLUHB3H1.7950.0202
152116GLUHG2H2.1430.0201
153116GLUHG3H2.1430.0201
154116GLUCAC54.2240.31
155116GLUCBC26.9930.31
156116GLUCGC33.4390.31
157116GLUNN119.7050.31
158117ASNHH8.1880.0201
159117ASNHAH4.5880.0201
160117ASNHB2H2.7100.0201
161117ASNHB3H2.7100.0201
162117ASNCAC50.4300.31
163117ASNCBC35.8450.31
164117ASNNN117.7720.31
165118GLNHH8.2500.0201
166118GLNHAH4.1410.0201
167118GLNHB2H1.9920.0202
168118GLNHB3H1.8100.0202
169118GLNHG2H2.1730.0201
170118GLNHG3H2.1730.0201
171118GLNCAC53.0560.31
172118GLNCBC26.6150.31
173118GLNCGC33.5170.31
174118GLNNN120.7950.31
175119GLUHH8.3690.0201
176119GLUHAH4.1260.0201
177119GLUHB2H1.9460.0202
178119GLUHB3H1.8100.0202
179119GLUHG2H2.1230.0201
180119GLUHG3H2.1230.0201
181119GLUCAC54.0290.31
182119GLUCBC26.6910.31
183119GLUCGC33.4390.31
184119GLUNN121.3530.31
185120GLUHH8.2850.0201
186120GLUHAH4.0650.0201
187120GLUHB2H1.8260.0201
188120GLUHB3H1.8260.0201
189120GLUHG2H2.1180.0201
190120GLUHG3H2.1180.0201
191120GLUCAC53.9640.31
192120GLUCBC26.9180.31
193120GLUCGC33.2830.31
194120GLUNN121.7210.31
195121GLUHH8.2280.0201
196121GLUHAH4.1260.0201
197121GLUHB2H1.9520.0202
198121GLUHB3H1.7850.0202
199121GLUHG2H2.1170.0201
200121GLUHG3H2.1170.0201
201121GLUCAC53.7050.31
202121GLUCBC27.1450.31
203121GLUCGC33.2830.31
204121GLUNN120.6160.31
205122GLUHH8.2980.0201
206122GLUHAH4.1860.0201
207122GLUHB2H1.9180.0202
208122GLUHB3H1.7570.0202
209122GLUHG2H2.1090.0201
210122GLUHG3H2.1090.0201
211122GLUCAC53.4780.31
212122GLUCBC27.8930.31
213122GLUCGC33.3610.31
214122GLUNN121.7740.31
215123GLUHH8.3140.0201
216123GLUHAH4.1780.0201
217123GLUHB2H1.7510.0202
218123GLUHB3H1.9400.0202
219123GLUHG2H2.1140.0201
220123GLUHG3H2.1140.0201
221123GLUCAC54.1530.31
222123GLUCBC27.0690.31
223123GLUCGC33.3610.31
224123GLUNN122.1490.31
225124ARGHH8.1860.0201
226124ARGHAH4.1560.0201
227124ARGHB2H1.7040.0202
228124ARGHB3H1.6210.0202
229124ARGHG2H1.4620.0201
230124ARGHG3H1.4620.0201
231124ARGHD2H3.0270.0201
232124ARGHD3H3.0270.0201
233124ARGCAC53.2190.31
234124ARGCBC27.5230.31
235124ARGCGC27.1120.31
236124ARGCDC40.0780.31
237124ARGNN122.2950.31
238125ALAHH8.2050.0201
239125ALAHAH4.1300.0201
240125ALAHB1H1.2360.0201
241125ALAHB2H1.2360.0201
242125ALAHB3H1.2360.0201
243125ALACAC49.9760.31
244125ALACBC16.1750.31
245125ALANN125.1740.31
246126GLUHH8.3030.0201
247126GLUHAH4.0800.0201
248126GLUHB2H1.8860.0202
249126GLUHB3H1.7800.0202
250126GLUHG2H2.1130.0201
251126GLUHG3H2.1130.0201
252126GLUCAC53.7050.31
253126GLUCBC26.7670.31
254126GLUCGC33.2050.31
255126GLUNN119.5710.31
256127LEUHH8.0640.0201
257127LEUHAH4.1710.0201
258127LEUHB2H1.4620.0201
259127LEUHB3H1.4620.0201
260127LEUHGH1.4620.0201
261127LEUHD11H0.8040.0201
262127LEUHD12H0.8040.0201
263127LEUHD13H0.8040.0201
264127LEUHD21H0.8040.0201
265127LEUHD22H0.8040.0201
266127LEUHD23H0.8040.0201
267127LEUCAC52.3430.31
268127LEUCBC39.2490.31
269127LEUCGC24.8470.31
270127LEUCD1C20.4940.31
271127LEUCD2C21.8170.31
272127LEUNN122.4380.31
273128ASNHH8.3280.0201
274128ASNHAH4.5350.0201
275128ASNHB2H2.7030.0202
276128ASNHB3H2.6120.0202
277128ASNCAC50.3650.31
278128ASNCBC35.9210.31
279128ASNNN119.2640.31
280129GLNHH8.2210.0201
281129GLNHAH4.1410.0201
282129GLNHB2H1.9770.0202
283129GLNHB3H1.8410.0202
284129GLNHG2H2.2190.0201
285129GLNHG3H2.2190.0201
286129GLNCAC53.0570.31
287129GLNCBC26.1610.31
288129GLNCGC29.9240.31
289129GLNNN120.1230.31
290130SERHH8.2580.0201
291130SERHAH4.2920.0201
292130SERHB2H3.7480.0201
293130SERHB3H3.7480.0201
294130SERCAC55.6180.31
295130SERCBC60.8860.31
296130SERNN116.8170.31
297131GLUHH8.3220.0201
298131GLUHAH4.0650.0201
299131GLUHB2H1.8840.0202
300131GLUHB3H1.7740.0202
301131GLUHG2H2.1020.0201
302131GLUHG3H2.1020.0201
303131GLUCAC53.0940.31
304131GLUCBC27.2200.31
305131GLUCGC33.3610.31
306131GLUNN122.4410.31
307132GLUHH8.4320.0201
308132GLUHAH4.0800.0201
309132GLUHB2H1.8380.0201
310132GLUHB3H1.8380.0201
311132GLUHG2H2.1130.0201
312132GLUHG3H2.1130.0201
313132GLUCAC53.9320.31
314132GLUCBC27.2200.31
315132GLUCGC33.2830.31
316132GLUNN121.6490.31
317134GLUHH8.4360.0201
318134GLUHAH4.0800.0201
319134GLUHB2H1.8930.0202
320134GLUHB3H1.7850.0202
321134GLUHG2H2.1660.0201
322134GLUHG3H2.1660.0201
323134GLUCAC53.4350.31
324134GLUCBC26.9930.31
325134GLUCGC33.4390.31
326134GLUNN121.2560.31
327135ALAHH8.3050.0201
328135ALAHAH4.1710.0201
329135ALAHB1H1.2450.0201
330135ALAHB2H1.2450.0201
331135ALAHB3H1.2450.0201
332135ALACAC49.7810.31
333135ALACBC16.2510.31
334135ALANN125.4320.31
335136GLYHH8.2470.0201
336136GLYHA2H3.8080.0201
337136GLYHA3H3.8080.0201
338136GLYCAC42.2260.31
339136GLYNN108.0660.31
340137GLUHH8.2190.0201
341137GLUHAH4.1710.0201
342137GLUHB2H1.9460.0202
343137GLUHB3H1.7950.0202
344137GLUHG2H2.1120.0201
345137GLUHG3H2.1120.0201
346137GLUCAC53.4630.31
347137GLUCBC27.2960.31
348137GLUCGC33.3610.31
349137GLUNN120.5280.31
350138SERHH8.3680.0201
351138SERHAH4.3530.0201
352138SERHB2H3.7630.0201
353138SERHB3H3.7630.0201
354138SERCAC55.4560.31
355138SERCBC60.7350.31
356138SERNN116.8550.31
357139SERHH8.3780.0201
358139SERHAH4.4290.0201
359139SERHB2H3.7630.0201
360139SERHB3H3.7630.0201
361139SERCAC55.5210.31
362139SERCBC60.6600.31
363139SERNN118.0320.31
364140THRHH8.1510.0201
365140THRHAH4.3100.0201
366140THRHBH4.2200.0201
367140THRHG21H1.0820.0201
368140THRHG22H1.0820.0201
369140THRHG23H1.0820.0201
370140THRCAC58.9040.31
371140THRCBC66.7790.31
372140THRCG2C18.6440.31
373140THRNN114.9180.31
374141GLYHH8.2660.0201
375141GLYHA2H3.8690.0201
376141GLYHA3H3.8690.0201
377141GLYCAC42.4200.31
378141GLYNN110.9810.31
379142GLYHH8.0180.0201
380142GLYHA2H4.0200.0202
381142GLYHA3H3.8990.0202
382142GLYCAC41.3500.31
383142GLYNN109.4280.31

Protein Blocks Logo
Calculated from 20 models in PDB: 6VXG, Strand ID: A Detail


Release date
2020-05-05
Citation 1
Signal transduction in receptor for advanced glycation end products (RAGE): solution structure of C-terminal rage (ctRAGE) and its binding to mDia1
Rai, V., Maldonado, A.Y., Burz, D.S., Reverdatto, S., Yan, S.F., Schmidt, A.M., Shekhtman, A.
J. Biol. Chem. (2012), 287, 5133-5144, PubMed 22194616 , DOI 10.1074/jbc.M111.277731 ,
Citation 2
Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice
Manigrasso, M.B., Rabbani, P., Egana-Gorrono, L., Quadri, N., Frye, L., Zhou, B., Reverdatto, S., Ramirez, L.S., Dansereau, S., Pan, J., Li, H., D'Agati, V.D., Ramasamy, R., DeVita, R.J., Shekhtman, A., Schmidt, A.M.
Sci. Transl. Med. (2021), 13, eabf7084-eabf7084, PubMed 34818060 , DOI 10.1126/scitranslmed.abf7084 ,
Related entities 1. Advanced glycosylation end product-specific receptor, entity 1, : 1 : 1 : 2 : 8 entities Detail
Interaction partners 1. Advanced glycosylation end product-specific receptor, entity 1, : 16 interactors Detail
Experiments performed 10 experiments Detail
nullKeywords Complex, Diabetes, Inflammation, Inhibitor, Receptor for Advanced Glycated End Products, SIGNALING PROTEIN