Pharmacological characterisation and NMR structure of the novel mu-conotoxin SxIIIC, a potent irreversible NaV channel inhibitor
ID | Type | Value order | Atom ID 1 | Atom ID 2 |
---|---|---|---|---|
1 | disulfide | sing | 1:CYS3:SG | 1:CYS15:SG |
2 | disulfide | sing | 1:CYS4:SG | 1:CYS21:SG |
3 | disulfide | sing | 1:CYS10:SG | 1:CYS22:SG |
Polymer type: polypeptide(L)
Total | 1H | 13C | 15N | |
---|---|---|---|---|
All | 81.0 % (183 of 226) | 99.2 % (117 of 118) | 63.3 % (50 of 79) | 55.2 % (16 of 29) |
Backbone | 78.0 % (103 of 132) | 97.9 % (47 of 48) | 64.5 % (40 of 62) | 72.7 % (16 of 22) |
Sidechain | 87.5 % (98 of 112) | 100.0 % (70 of 70) | 80.0 % (28 of 35) | 0.0 % (0 of 7) |
Aromatic | 50.0 % (8 of 16) | 100.0 % (8 of 8) | 0.0 % (0 of 7) | 0.0 % (0 of 1) |
Methyl | 100.0 % (2 of 2) | 100.0 % (1 of 1) | 100.0 % (1 of 1) |
1. entity 1
RGCCNGRGGC SSRWCRDHAR CCXSolvent system 90% H2O/10% D2O, Pressure 1 null, Temperature 298 K, pH 4, Details 1 mg/mL SxIIIC, 90% H2O/10% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | SxIIIC | natural abundance | 1 mg/mL |
Solvent system 100% D2O, Pressure 1 null, Temperature 298 K, pH 4, Details 1 mg/mL SxIIIC, 100% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
2 | SxIIIC | natural abundance | 1 mg/mL |