BMRB: 31076

Taipan Natriuretic Peptide C -TNPc

Authors

Torres, A.M., Alewood, P.F.

Assembly

Peptide TNP-c

Entity

1. Peptide TNP-c (polymer), 39 monomers, 4114.645 Da Detail

SDSKIGNGCF GFPLDRIGSV SGLGCNRIMQ NPPKKFSGE

Formula weight

4114.645 Da

Source organism

Oxyuranus microlepidotus

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chemcal Shifts

¹H: 193 assignments Detail

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ID	Entity ID	Seq ID	Comp ID	Atom ID	Atom type	Val	Val err	Ambig. code
1	1	1	SER	HA	H	4.167	0.000
2	1	1	SER	HB3	H	3.992	0.000
3	1	2	ASP	H	H	8.896	0.001
4	1	2	ASP	HA	H	4.745	0.000
5	1	2	ASP	HB2	H	2.681	0.000
6	1	2	ASP	HB3	H	2.807	0.000
7	1	3	SER	H	H	8.438	0.002
8	1	3	SER	HA	H	4.739	0.002
9	1	3	SER	HB2	H	2.827	0.000
10	1	4	LYS	H	H	8.552	0.000
11	1	4	LYS	HA	H	4.346	0.001
12	1	4	LYS	HB2	H	1.755	0.025
13	1	4	LYS	HB3	H	1.841	0.003
14	1	4	LYS	HG2	H	1.440	0.001
15	1	4	LYS	HD2	H	1.666	0.005
16	1	4	LYS	HE2	H	2.875	0.390
17	1	4	LYS	HZ1	H	7.560	0.004
18	1	4	LYS	HZ2	H	7.560	0.004
19	1	4	LYS	HZ3	H	7.560	0.004
20	1	5	ILE	H	H	8.212	0.000
21	1	5	ILE	HA	H	4.128	0.001
22	1	5	ILE	HB	H	1.843	0.001
23	1	5	ILE	HG12	H	1.184	0.001
24	1	5	ILE	HG13	H	1.486	0.000
25	1	5	ILE	HG21	H	0.900	0.000
26	1	5	ILE	HG22	H	0.900	0.000
27	1	5	ILE	HG23	H	0.900	0.000
28	1	5	ILE	HD11	H	0.900	0.000
29	1	5	ILE	HD12	H	0.900	0.000
30	1	5	ILE	HD13	H	0.900	0.000
31	1	6	GLY	H	H	8.508	0.002
32	1	6	GLY	HA2	H	3.841	0.004
33	1	7	ASN	H	H	8.127	0.003
34	1	7	ASN	HA	H	4.560	0.003
35	1	7	ASN	HB2	H	2.697	0.002
36	1	7	ASN	HB3	H	2.815	0.002
37	1	7	ASN	HD21	H	6.974	0.005
38	1	7	ASN	HD22	H	7.658	0.006
39	1	8	GLY	H	H	8.460	0.003
40	1	8	GLY	HA2	H	3.965	0.005
41	1	9	CYS	H	H	8.579	0.000
42	1	9	CYS	HA	H	4.653	0.001
43	1	9	CYS	HB2	H	2.836	0.003
44	1	9	CYS	HB3	H	3.091	0.000
45	1	10	PHE	H	H	8.395	0.002
46	1	10	PHE	HA	H	4.520	0.001
47	1	10	PHE	HB2	H	3.034	0.010
48	1	10	PHE	HB3	H	3.125	0.000
49	1	10	PHE	HD1	H	7.228	0.003
50	1	11	GLY	H	H	8.388	0.001
51	1	11	GLY	HA2	H	3.628	0.001
52	1	12	PHE	H	H	7.982	0.002
53	1	12	PHE	HA	H	4.850	0.002
54	1	12	PHE	HB2	H	2.955	0.002
55	1	12	PHE	HB3	H	3.139	0.001
56	1	12	PHE	HD1	H	7.253	0.004
57	1	13	PRO	HA	H	4.434	0.003
58	1	13	PRO	HB2	H	2.012	0.006
59	1	13	PRO	HB3	H	2.296	0.003
60	1	13	PRO	HD2	H	3.548	0.003
61	1	14	LEU	H	H	8.411	0.000
62	1	14	LEU	HA	H	4.274	0.002
63	1	14	LEU	HB2	H	1.674	0.002
64	1	14	LEU	HD11	H	0.905	0.003
65	1	14	LEU	HD12	H	0.905	0.003
66	1	14	LEU	HD13	H	0.905	0.003
67	1	15	ASP	H	H	8.352	0.003
68	1	15	ASP	HA	H	4.599	0.002
69	1	15	ASP	HB3	H	2.795	0.000
70	1	16	ARG	H	H	8.144	0.001
71	1	16	ARG	HA	H	4.352	0.000
72	1	16	ARG	HB2	H	1.748	0.000
73	1	16	ARG	HB3	H	1.866	0.005
74	1	16	ARG	HG2	H	1.601	0.000
75	1	16	ARG	HD2	H	3.155	0.003
76	1	16	ARG	HH22	H	7.232	0.004
77	1	17	ILE	H	H	8.163	0.000
78	1	17	ILE	HA	H	4.128	0.002
79	1	17	ILE	HB	H	1.894	0.002
80	1	17	ILE	HG12	H	1.203	0.003
81	1	17	ILE	HG21	H	0.911	0.002
82	1	17	ILE	HG22	H	0.911	0.002
83	1	17	ILE	HG23	H	0.911	0.002
84	1	18	GLY	H	H	8.607	0.002
85	1	18	GLY	HA2	H	3.914	0.004
86	1	18	GLY	HA3	H	4.032	0.003
87	1	19	SER	H	H	8.222	0.002
88	1	19	SER	HA	H	4.494	0.004
89	1	19	SER	HB2	H	3.888	0.000
90	1	20	VAL	H	H	8.293	0.000
91	1	20	VAL	HA	H	4.214	0.000
92	1	20	VAL	HB	H	2.136	0.002
93	1	20	VAL	HG11	H	0.929	0.002
94	1	20	VAL	HG12	H	0.929	0.002
95	1	20	VAL	HG13	H	0.929	0.002
96	1	21	SER	H	H	8.428	0.004
97	1	21	SER	HA	H	4.398	0.002
98	1	21	SER	HB2	H	3.864	0.002
99	1	22	GLY	H	H	8.431	0.004
100	1	22	GLY	HA2	H	3.949	0.003
101	1	23	LEU	H	H	8.177	0.002
102	1	23	LEU	HA	H	4.351	0.004
103	1	23	LEU	HB2	H	1.604	0.002
104	1	23	LEU	HD11	H	0.904	0.004
105	1	23	LEU	HD12	H	0.904	0.004
106	1	23	LEU	HD13	H	0.904	0.004
107	1	24	GLY	H	H	8.548	0.002
108	1	24	GLY	HA2	H	3.926	0.005
109	1	25	CYS	H	H	8.284	0.002
110	1	25	CYS	HA	H	4.599	0.004
111	1	25	CYS	HB2	H	2.848	0.003
112	1	25	CYS	HB3	H	3.045	0.003
113	1	26	ASN	H	H	8.626	0.004
114	1	26	ASN	HA	H	4.694	0.002
115	1	26	ASN	HB2	H	2.758	0.000
116	1	26	ASN	HB3	H	2.830	0.002
117	1	26	ASN	HD21	H	6.983	0.003
118	1	26	ASN	HD22	H	7.658	0.003
119	1	27	ARG	H	H	8.237	0.003
120	1	27	ARG	HA	H	4.322	0.001
121	1	27	ARG	HB2	H	1.732	0.000
122	1	27	ARG	HB3	H	1.831	0.000
123	1	27	ARG	HG2	H	1.579	0.004
124	1	27	ARG	HD2	H	3.156	0.005
125	1	27	ARG	HH22	H	7.220	0.005
126	1	28	ILE	H	H	8.213	0.001
127	1	28	ILE	HA	H	4.183	0.006
128	1	28	ILE	HB	H	1.853	0.000
129	1	28	ILE	HG12	H	1.185	0.000
130	1	28	ILE	HG13	H	1.472	0.000
131	1	28	ILE	HG21	H	0.893	0.012
132	1	28	ILE	HG22	H	0.893	0.012
133	1	28	ILE	HG23	H	0.893	0.012
134	1	29	MET	H	H	8.504	0.002
135	1	29	MET	HA	H	4.469	0.003
136	1	29	MET	HB2	H	1.978	0.000
137	1	29	MET	HG2	H	2.503	0.000
138	1	29	MET	HG3	H	2.563	0.003
139	1	30	GLN	H	H	8.436	0.002
140	1	30	GLN	HA	H	4.303	0.002
141	1	30	GLN	HB2	H	1.947	0.002
142	1	30	GLN	HB3	H	2.057	0.001
143	1	30	GLN	HG2	H	2.347	0.002
144	1	30	GLN	HE21	H	6.933	0.002
145	1	30	GLN	HE22	H	7.593	0.002
146	1	31	ASN	H	H	8.622	0.003
147	1	31	ASN	HA	H	4.978	0.000
148	1	31	ASN	HB2	H	2.619	0.001
149	1	31	ASN	HB3	H	2.760	0.005
150	1	31	ASN	HD21	H	6.990	0.004
151	1	31	ASN	HD22	H	7.680	0.006
152	1	32	PRO	HA	H	4.411	0.004
153	1	32	PRO	HB2	H	2.023	0.004
154	1	32	PRO	HB3	H	2.298	0.004
155	1	32	PRO	HG2	H	1.891	0.000
156	1	32	PRO	HD2	H	3.632	0.001
157	1	33	PRO	HA	H	4.421	0.002
158	1	33	PRO	HB2	H	2.015	0.000
159	1	33	PRO	HB3	H	2.293	0.000
160	1	33	PRO	HG2	H	1.891	0.007
161	1	33	PRO	HD2	H	3.803	0.002
162	1	34	LYS	H	H	8.463	0.001
163	1	34	LYS	HA	H	4.220	0.008
164	1	34	LYS	HB2	H	1.693	0.003
165	1	34	LYS	HG2	H	1.403	0.014
166	1	34	LYS	HE2	H	3.001	0.000
167	1	34	LYS	HZ1	H	7.577	0.005
168	1	34	LYS	HZ2	H	7.577	0.005
169	1	34	LYS	HZ3	H	7.577	0.005
170	1	35	LYS	H	H	8.422	0.002
171	1	35	LYS	HA	H	4.256	0.001
172	1	35	LYS	HB2	H	1.679	0.000
173	1	35	LYS	HG2	H	1.357	0.000
174	1	35	LYS	HE2	H	2.966	0.000
175	1	35	LYS	HZ1	H	7.591	0.010
176	1	35	LYS	HZ2	H	7.591	0.010
177	1	35	LYS	HZ3	H	7.591	0.010
178	1	36	PHE	H	H	8.476	0.002
179	1	36	PHE	HA	H	4.654	0.002
180	1	36	PHE	HB2	H	3.057	0.000
181	1	36	PHE	HB3	H	3.140	0.004
182	1	36	PHE	HE1	H	7.277	0.000
183	1	37	SER	H	H	8.523	0.002
184	1	37	SER	HA	H	4.421	0.000
185	1	37	SER	HB2	H	3.850	0.000
186	1	38	GLY	H	H	8.024	0.004
187	1	38	GLY	HA2	H	3.864	0.001
188	1	38	GLY	HA3	H	3.994	0.006
189	1	39	GLU	H	H	7.932	0.001
190	1	39	GLU	HA	H	4.217	0.000
191	1	39	GLU	HB2	H	1.892	0.002
192	1	39	GLU	HB3	H	2.115	0.000
193	1	39	GLU	HG3	H	2.367	0.001

Release date

2023-04-04

Citation

Taipan Natriuretic Peptides Are Potent and Selective Agonists for the Natriuretic Peptide Receptor A
Vink, S., Akondi, K.B., Jin, J., Poth, K., Torres, A.M., Kuchel, P.W., Burke, S.L., Head, G.A., Alewood, P.F.
Molecules (2023), 28, 3063-3063, PubMed 37049825 , DOI 10.3390/molecules28073063 , Abstract

Related entities 1. Peptide TNP-c, : 1 : 1 : 13 entities Detail

Experiments performed 3 experiments Detail

Chemical shift validation 3 contents Detail