BMRB: 31105

Solution structure of TET3/MLL4-PHD6

Authors

Mohid, S.A., Zandian, M., Zhang, Y., Kutateladze, T.G.

Assembly

Methylcytosine dioxygenase TET3 (E.C.1.14.11.80), Histone-lysine N-methyltransferase 2D (E.C.2.1.1.364)

Entity

1. Methylcytosine dioxygenase TET3 (E.C.1.14.11.80), Histone-lysine N-methyltransferase 2D (E.C.2.1.1.364), entity 1 (polymer, Thiol state: not present), 9 monomers, 864.9448 Da Detail

GVGGSWGVF

2. Methylcytosine dioxygenase TET3 (E.C.1.14.11.80), Histone-lysine N-methyltransferase 2D (E.C.2.1.1.364), entity 2 (polymer, Thiol state: all other bound), 60 monomers, 6820.625 Da Detail

SLVTCPICHA PYVEEDLLIQ CRHCERWMHA GCESLFTEDD VEQAADEGFD CVSCQPYVVK

3. Methylcytosine dioxygenase TET3 (E.C.1.14.11.80), Histone-lysine N-methyltransferase 2D (E.C.2.1.1.364), entity ZN (non-polymer), 65.409 × 2 Da

Total weight

7816.3877 Da

Max. entity weight

6820.625 Da

Entity Connection

na 8 Detail

---

ID	Type	Value order	Atom ID 1	Atom ID 2
1	na	sing	2:CYS5:SG	3:ZN1:ZN
2	na	sing	2:CYS8:SG	3:ZN1:ZN
3	na	sing	2:HIS29:ND1	3:ZN1:ZN
4	na	sing	2:CYS32:SG	3:ZN1:ZN
5	na	sing	2:CYS21:SG	3:ZN1:ZN
6	na	sing	2:CYS24:SG	3:ZN1:ZN
7	na	sing	2:CYS51:SG	3:ZN1:ZN
8	na	sing	2:CYS54:SG	3:ZN1:ZN

Source organism

Homo sapiens

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chemcal Shifts

¹H: 355, ¹³C: 246, ¹⁵N: 68 assignments Detail

Download

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ID	Entity ID	Seq ID	Comp ID	Atom ID	Atom type	Val	Val err	Ambig. code
1	1	1	GLY	H	H	8.355	0.003	1
2	1	1	GLY	HA2	H	3.963	0.013	1
3	1	1	GLY	HA3	H	3.963	0.013	1
4	1	1	GLY	CA	C	45.362	0.171	1
5	1	1	GLY	N	N	109.272	0.078	1
6	1	2	VAL	H	H	7.986	0.005	1
7	1	2	VAL	HA	H	4.182	0.018	1
8	1	2	VAL	HB	H	2.116	0.013	1
9	1	2	VAL	HG11	H	0.872	0.013	1
10	1	2	VAL	HG12	H	0.872	0.013	1
11	1	2	VAL	HG13	H	0.872	0.013	1
12	1	2	VAL	HG21	H	0.872	0.013	1
13	1	2	VAL	HG22	H	0.872	0.013	1
14	1	2	VAL	HG23	H	0.872	0.013	1
15	1	2	VAL	CA	C	62.382	0.029	1
16	1	2	VAL	CB	C	32.739	0.057	1
17	1	2	VAL	CG1	C	20.284	0.001	1
18	1	2	VAL	CG2	C	20.284	0.001	1
19	1	2	VAL	N	N	118.712	0.059	1
20	1	3	GLY	H	H	8.496	0.022	1
21	1	3	GLY	HA2	H	3.956	0.002	1
22	1	3	GLY	HA3	H	4.016	0.004	1
23	1	3	GLY	CA	C	45.293	0.121	1
24	1	3	GLY	N	N	112.083	0.132	1
25	1	4	GLY	H	H	8.220	0.012	1
26	1	4	GLY	HA2	H	3.969	0.016	1
27	1	4	GLY	HA3	H	4.158	0.004	1
28	1	4	GLY	CA	C	45.259	0.054	1
29	1	4	GLY	N	N	108.451	0.055	1
30	1	5	SER	H	H	8.456	0.011	1
31	1	5	SER	HB3	H	3.907	0.011	1
32	1	5	SER	CA	C	58.435	0.025	1
33	1	5	SER	CB	C	64.457	0.081	1
34	1	5	SER	N	N	115.402	0.089	1
35	1	6	TRP	H	H	8.084	0.004	1
36	1	6	TRP	HA	H	5.129	0.005	1
37	1	6	TRP	HB2	H	3.813	0.013	1
38	1	6	TRP	HB3	H	3.137	0.009	1
39	1	6	TRP	HD1	H	6.994	0.045	1
40	1	6	TRP	HE1	H	10.364	0.004	1
41	1	6	TRP	HE3	H	7.417	0.001	1
42	1	6	TRP	HZ2	H	7.415	0.000	1
43	1	6	TRP	HZ3	H	6.916	0.009	1
44	1	6	TRP	HH2	H	7.169	0.010	1
45	1	6	TRP	CA	C	56.263	0.023	1
46	1	6	TRP	CB	C	30.407	0.174	1
47	1	6	TRP	CD1	C	126.988	0.029	1
48	1	6	TRP	CE3	C	120.450	0.052	1
49	1	6	TRP	CZ2	C	114.266	0.022	1
50	1	6	TRP	CZ3	C	121.036	0.054	1
51	1	6	TRP	CH2	C	124.178	0.028	1
52	1	6	TRP	N	N	118.211	0.084	1
53	1	6	TRP	NE1	N	130.265	0.010	1
54	1	7	GLY	H	H	8.941	0.003	1
55	1	7	GLY	HA2	H	3.903	0.014	1
56	1	7	GLY	HA3	H	3.525	0.006	1
57	1	7	GLY	CA	C	45.758	0.002	1
58	1	7	GLY	N	N	106.812	0.077	1
59	1	8	VAL	H	H	8.190	0.006	1
60	1	8	VAL	HA	H	4.206	0.029	1
61	1	8	VAL	HB	H	2.129	0.011	1
62	1	8	VAL	HG11	H	0.897	0.006	1
63	1	8	VAL	HG12	H	0.897	0.006	1
64	1	8	VAL	HG13	H	0.897	0.006	1
65	1	8	VAL	HG21	H	0.932	0.001	1
66	1	8	VAL	HG22	H	0.932	0.001	1
67	1	8	VAL	HG23	H	0.932	0.001	1
68	1	8	VAL	CA	C	62.240	0.088	1
69	1	8	VAL	CB	C	32.690	0.148	1
70	1	8	VAL	CG1	C	20.203	0.000	1
71	1	8	VAL	CG2	C	21.207	0.001	1
72	1	8	VAL	N	N	118.451	0.225	1
73	1	9	PHE	H	H	9.381	0.005	1
74	1	9	PHE	HA	H	4.137	0.002	1
75	1	9	PHE	HB2	H	3.105	0.013	1
76	1	9	PHE	HB3	H	2.693	0.010	1
77	1	9	PHE	HD1	H	6.745	0.012	1
78	1	9	PHE	HE1	H	7.245	0.008	1
79	1	9	PHE	CA	C	59.741	0.016	1
80	1	9	PHE	CB	C	39.406	0.051	1
81	1	9	PHE	CD1	C	131.239	0.078	1
82	1	9	PHE	CE1	C	131.233	0.044	1
83	1	9	PHE	N	N	127.847	0.063	1
84	2	1	SER	HA	H	4.753	0.000	1
85	2	1	SER	HB2	H	3.947	0.008	1
86	2	1	SER	HB3	H	3.989	0.009	1
87	2	1	SER	CA	C	59.591	0.013	1
88	2	1	SER	CB	C	63.558	0.089	1
89	2	2	LEU	H	H	8.147	0.002	1
90	2	2	LEU	HA	H	4.425	0.000	1
91	2	2	LEU	HB2	H	1.719	0.000	1
92	2	2	LEU	HB3	H	1.563	0.000	1
93	2	2	LEU	HG	H	1.564	0.000	1
94	2	2	LEU	HD11	H	0.580	0.000	1
95	2	2	LEU	HD12	H	0.580	0.000	1
96	2	2	LEU	HD13	H	0.580	0.000	1
97	2	2	LEU	HD21	H	0.771	0.000	1
98	2	2	LEU	HD22	H	0.771	0.000	1
99	2	2	LEU	HD23	H	0.771	0.000	1
100	2	2	LEU	CA	C	55.597	0.000	1
101	2	2	LEU	CB	C	42.377	0.000	1
102	2	2	LEU	CG	C	27.138	0.000	1
103	2	2	LEU	CD1	C	23.243	0.000	1
104	2	2	LEU	CD2	C	25.084	0.000	1
105	2	2	LEU	N	N	122.018	0.000	1
106	2	3	VAL	H	H	8.038	0.000	1
107	2	3	VAL	HA	H	4.285	0.000	1
108	2	3	VAL	HB	H	2.143	0.000	1
109	2	3	VAL	HG11	H	0.925	0.000	1
110	2	3	VAL	HG12	H	0.925	0.000	1
111	2	3	VAL	HG13	H	0.925	0.000	1
112	2	3	VAL	HG21	H	0.925	0.000	1
113	2	3	VAL	HG22	H	0.925	0.000	1
114	2	3	VAL	HG23	H	0.925	0.000	1
115	2	3	VAL	C	C	175.332	0.000	1
116	2	3	VAL	CA	C	63.282	0.000	1
117	2	3	VAL	CB	C	33.483	0.000	1
118	2	3	VAL	CG1	C	20.500	0.000	1
119	2	3	VAL	CG2	C	21.656	0.000	1
120	2	3	VAL	N	N	118.179	0.000	1
121	2	4	THR	H	H	7.709	0.000	1
122	2	4	THR	HA	H	3.999	0.000	1
123	2	4	THR	HB	H	3.453	0.000	1
124	2	4	THR	HG21	H	0.788	0.000	1
125	2	4	THR	HG22	H	0.788	0.000	1
126	2	4	THR	HG23	H	0.788	0.000	1
127	2	4	THR	C	C	172.474	0.000	1
128	2	4	THR	CA	C	59.348	0.000	1
129	2	4	THR	CB	C	71.908	0.000	1
130	2	4	THR	CG2	C	21.702	0.000	1
131	2	4	THR	N	N	114.071	0.000	1
132	2	5	CYS	H	H	7.613	0.000	1
133	2	5	CYS	HA	H	4.984	0.000	1
134	2	5	CYS	HB3	H	3.385	0.000	1
135	2	5	CYS	CA	C	56.065	0.000	1
136	2	5	CYS	CB	C	32.256	0.000	1
137	2	5	CYS	N	N	127.339	0.000	1
138	2	6	PRO	HA	H	4.572	0.000	1
139	2	6	PRO	HG3	H	2.033	0.000	1
140	2	6	PRO	HD3	H	3.832	0.000	1
141	2	6	PRO	CB	C	32.178	0.000	1
142	2	6	PRO	CG	C	27.321	0.000	1
143	2	6	PRO	CD	C	50.615	0.000	1
144	2	7	ILE	H	H	8.874	0.000	1
145	2	7	ILE	HA	H	4.003	0.000	1
146	2	7	ILE	HB	H	2.017	0.000	1
147	2	7	ILE	HG13	H	1.560	0.000	1
148	2	7	ILE	HG21	H	1.019	0.000	1
149	2	7	ILE	HG22	H	1.019	0.000	1
150	2	7	ILE	HG23	H	1.019	0.000	1
151	2	7	ILE	HD11	H	0.937	0.000	1
152	2	7	ILE	HD12	H	0.937	0.000	1
153	2	7	ILE	HD13	H	0.937	0.000	1
154	2	7	ILE	C	C	176.259	0.000	1
155	2	7	ILE	CA	C	63.065	0.000	1
156	2	7	ILE	CB	C	37.853	0.000	1
157	2	7	ILE	CG1	C	27.977	0.000	1
158	2	7	ILE	CG2	C	17.254	0.000	1
159	2	7	ILE	CD1	C	13.083	0.000	1
160	2	7	ILE	N	N	121.382	0.000	1
161	2	8	CYS	H	H	7.712	0.000	1
162	2	8	CYS	HB3	H	3.221	0.000	1
163	2	8	CYS	C	C	176.448	0.000	1
164	2	8	CYS	CB	C	31.301	0.000	1
165	2	8	CYS	N	N	115.711	0.000	1
166	2	9	HIS	H	H	7.719	0.000	1
167	2	9	HIS	HA	H	4.419	0.000	1
168	2	9	HIS	HB3	H	3.322	0.000	1
169	2	9	HIS	HD2	H	6.987	0.000	1
170	2	9	HIS	CA	C	56.103	0.000	1
171	2	9	HIS	CB	C	26.504	0.000	1
172	2	9	HIS	CD2	C	119.484	0.000	1
173	2	9	HIS	N	N	116.849	0.000	1
174	2	10	ALA	H	H	8.476	0.000	1
175	2	10	ALA	HA	H	4.940	0.000	1
176	2	10	ALA	HB1	H	1.534	0.000	1
177	2	10	ALA	HB2	H	1.534	0.000	1
178	2	10	ALA	HB3	H	1.534	0.000	1
179	2	10	ALA	CA	C	50.073	0.000	1
180	2	10	ALA	CB	C	20.110	0.000	1
181	2	10	ALA	N	N	124.968	0.000	1
182	2	11	PRO	HA	H	4.469	0.000	1
183	2	11	PRO	HB3	H	2.405	0.000	1
184	2	11	PRO	HG3	H	2.033	0.000	1
185	2	11	PRO	HD3	H	4.250	0.000	1
186	2	11	PRO	CA	C	64.222	0.000	1
187	2	11	PRO	CB	C	32.311	0.000	1
188	2	11	PRO	CG	C	27.711	0.000	1
189	2	11	PRO	CD	C	52.440	0.000	1
190	2	12	TYR	HA	H	4.772	0.000	1
191	2	12	TYR	HD1	H	6.482	0.000	1
192	2	12	TYR	HD2	H	6.482	0.000	1
193	2	12	TYR	HE1	H	6.142	0.000	1
194	2	12	TYR	HE2	H	6.142	0.000	1
195	2	12	TYR	CD1	C	131.923	0.000	1
196	2	12	TYR	CD2	C	131.923	0.000	1
197	2	12	TYR	CE1	C	117.229	0.000	1
198	2	12	TYR	CE2	C	117.229	0.000	1
199	2	13	VAL	HA	H	4.497	0.000	1
200	2	13	VAL	HB	H	2.274	0.000	1
201	2	13	VAL	HG11	H	1.015	0.000	1
202	2	13	VAL	HG12	H	1.015	0.000	1
203	2	13	VAL	HG13	H	1.015	0.000	1
204	2	13	VAL	HG21	H	1.015	0.000	1
205	2	13	VAL	HG22	H	1.015	0.000	1
206	2	13	VAL	HG23	H	1.015	0.000	1
207	2	13	VAL	C	C	176.262	0.000	1
208	2	13	VAL	CB	C	34.468	0.000	1
209	2	13	VAL	CG1	C	21.506	0.000	1
210	2	13	VAL	CG2	C	20.054	0.000	1
211	2	14	GLU	H	H	8.625	0.000	1
212	2	14	GLU	HA	H	3.869	0.000	1
213	2	14	GLU	HB3	H	1.990	0.000	1
214	2	14	GLU	HG3	H	2.345	0.000	1
215	2	14	GLU	CA	C	59.587	0.000	1
216	2	14	GLU	CB	C	29.726	0.000	1
217	2	14	GLU	CG	C	36.456	0.000	1
218	2	14	GLU	N	N	123.030	0.000	1
219	2	15	GLU	H	H	8.702	0.000	1
220	2	15	GLU	HA	H	3.888	0.000	1
221	2	15	GLU	HG3	H	2.210	0.000	1
222	2	15	GLU	CA	C	58.633	0.000	1
223	2	15	GLU	CG	C	36.782	0.000	1
224	2	15	GLU	N	N	122.620	0.000	1
225	2	16	ASP	H	H	9.036	0.000	1
226	2	16	ASP	HA	H	4.588	0.000	1
227	2	16	ASP	HB3	H	2.493	0.000	1
228	2	16	ASP	C	C	176.249	0.000	1
229	2	16	ASP	CA	C	55.982	0.000	1
230	2	16	ASP	CB	C	42.589	0.000	1
231	2	16	ASP	N	N	119.896	0.000	1
232	2	17	LEU	H	H	8.598	0.000	1
233	2	17	LEU	HA	H	4.631	0.000	1
234	2	17	LEU	HB3	H	1.618	0.000	1
235	2	17	LEU	HG	H	1.506	0.000	1
236	2	17	LEU	HD21	H	0.831	0.000	1
237	2	17	LEU	HD22	H	0.831	0.000	1
238	2	17	LEU	HD23	H	0.831	0.000	1
239	2	17	LEU	CB	C	42.528	0.000	1
240	2	17	LEU	CG	C	27.111	0.000	1
241	2	17	LEU	CD1	C	23.977	0.000	1
242	2	17	LEU	CD2	C	24.895	0.000	1
243	2	17	LEU	N	N	122.066	0.000	1
244	2	18	LEU	H	H	9.205	0.000	1
245	2	18	LEU	HA	H	5.279	0.000	1
246	2	18	LEU	HB3	H	1.656	0.000	1
247	2	18	LEU	HG	H	1.396	0.000	1
248	2	18	LEU	C	C	174.812	0.000	1
249	2	18	LEU	CA	C	53.852	0.000	1
250	2	18	LEU	CB	C	46.493	0.000	1
251	2	18	LEU	CG	C	27.198	0.000	1
252	2	18	LEU	CD2	C	24.341	0.000	1
253	2	18	LEU	N	N	128.881	0.000	1
254	2	19	ILE	H	H	8.852	0.000	1
255	2	19	ILE	HB	H	1.214	0.000	1
256	2	19	ILE	HG13	H	1.316	0.000	1
257	2	19	ILE	HG21	H	0.230	0.000	1
258	2	19	ILE	HG22	H	0.230	0.000	1
259	2	19	ILE	HG23	H	0.230	0.000	1
260	2	19	ILE	HD11	H	0.066	0.000	1
261	2	19	ILE	HD12	H	0.066	0.000	1
262	2	19	ILE	HD13	H	0.066	0.000	1
263	2	19	ILE	C	C	170.792	0.000	1
264	2	19	ILE	CB	C	43.650	0.000	1
265	2	19	ILE	CG1	C	28.757	0.000	1
266	2	19	ILE	CG2	C	14.761	0.000	1
267	2	19	ILE	CD1	C	14.729	0.000	1
268	2	19	ILE	N	N	117.831	0.000	1
269	2	20	GLN	H	H	7.541	0.000	1
270	2	20	GLN	HA	H	4.517	0.000	1
271	2	20	GLN	HB3	H	1.016	0.000	1
272	2	20	GLN	HG3	H	0.504	0.000	1
273	2	20	GLN	HE21	H	6.862	0.000	1
274	2	20	GLN	HE22	H	6.746	0.000	1
275	2	20	GLN	C	C	175.503	0.000	1
276	2	20	GLN	CB	C	28.976	0.000	1
277	2	20	GLN	CG	C	32.467	0.000	1
278	2	20	GLN	N	N	126.642	0.000	1
279	2	20	GLN	NE2	N	109.704	0.000	1
280	2	21	CYS	H	H	8.227	0.000	1
281	2	21	CYS	HA	H	4.590	0.000	1
282	2	21	CYS	HB3	H	3.446	0.000	1
283	2	21	CYS	C	C	177.308	0.000	1
284	2	21	CYS	CB	C	32.291	0.000	1
285	2	21	CYS	N	N	128.075	0.000	1
286	2	22	ARG	H	H	8.979	0.000	1
287	2	22	ARG	HA	H	4.153	0.000	1
288	2	22	ARG	HB3	H	1.767	0.000	1
289	2	22	ARG	HG3	H	1.801	0.000	1
290	2	22	ARG	HD3	H	3.094	0.000	1
291	2	22	ARG	C	C	175.830	0.000	1
292	2	22	ARG	CA	C	57.828	0.000	1
293	2	22	ARG	CB	C	29.780	0.000	1
294	2	22	ARG	CG	C	25.344	0.000	1
295	2	22	ARG	CD	C	44.342	0.000	1
296	2	22	ARG	N	N	128.682	0.000	1
297	2	23	HIS	H	H	9.385	0.000	1
298	2	23	HIS	HA	H	4.528	0.000	1
299	2	23	HIS	HB3	H	3.734	0.000	1
300	2	23	HIS	HD2	H	7.511	0.000	1
301	2	23	HIS	CB	C	29.562	0.000	1
302	2	23	HIS	CD2	C	120.714	0.000	1
303	2	23	HIS	N	N	124.072	0.000	1
304	2	24	CYS	H	H	8.623	0.000	1
305	2	24	CYS	HA	H	4.642	0.000	1
306	2	24	CYS	HB3	H	2.794	0.000	1
307	2	24	CYS	C	C	175.924	0.000	1
308	2	24	CYS	CB	C	31.137	0.000	1
309	2	24	CYS	N	N	118.554	0.000	1
310	2	25	GLU	H	H	7.257	0.000	1
311	2	25	GLU	HA	H	3.980	0.000	1
312	2	25	GLU	HB3	H	2.088	0.000	1
313	2	25	GLU	HG3	H	1.865	0.000	1
314	2	25	GLU	C	C	175.497	0.000	1
315	2	25	GLU	CA	C	58.674	0.000	1
316	2	25	GLU	CB	C	27.361	0.000	1
317	2	25	GLU	CG	C	37.597	0.000	1
318	2	25	GLU	N	N	114.877	0.000	1
319	2	26	ARG	H	H	8.094	0.000	1
320	2	26	ARG	HA	H	4.384	0.000	1
321	2	26	ARG	HB3	H	1.816	0.000	1
322	2	26	ARG	HG3	H	1.950	0.000	1
323	2	26	ARG	HD3	H	3.406	0.000	1
324	2	26	ARG	C	C	175.509	0.000	1
325	2	26	ARG	CA	C	57.364	0.000	1
326	2	26	ARG	CB	C	31.795	0.000	1
327	2	26	ARG	CG	C	27.411	0.000	1
328	2	26	ARG	CD	C	44.385	0.000	1
329	2	26	ARG	N	N	120.887	0.000	1
330	2	27	TRP	H	H	8.193	0.000	1
331	2	27	TRP	HA	H	4.941	0.000	1
332	2	27	TRP	HB3	H	2.944	0.000	1
333	2	27	TRP	HD1	H	7.200	0.000	1
334	2	27	TRP	HE1	H	10.138	0.000	1
335	2	27	TRP	HE3	H	7.130	0.000	1
336	2	27	TRP	HZ2	H	7.287	0.000	1
337	2	27	TRP	HZ3	H	6.633	0.000	1
338	2	27	TRP	HH2	H	6.932	0.000	1
339	2	27	TRP	C	C	175.564	0.000	1
340	2	27	TRP	CA	C	56.359	0.000	1
341	2	27	TRP	CB	C	30.749	0.000	1
342	2	27	TRP	CD1	C	127.278	0.000	1
343	2	27	TRP	CE3	C	119.999	0.000	1
344	2	27	TRP	CZ2	C	114.955	0.000	1
345	2	27	TRP	CZ3	C	121.462	0.000	1
346	2	27	TRP	CH2	C	124.054	0.000	1
347	2	27	TRP	N	N	120.819	0.000	1
348	2	27	TRP	NE1	N	129.807	0.000	1
349	2	28	MET	H	H	8.661	0.000	1
350	2	28	MET	HA	H	5.384	0.000	1
351	2	28	MET	HB3	H	2.354	0.000	1
352	2	28	MET	HG3	H	2.581	0.000	1
353	2	28	MET	HE1	H	1.932	0.000	1
354	2	28	MET	HE2	H	1.932	0.000	1
355	2	28	MET	HE3	H	1.932	0.000	1
356	2	28	MET	C	C	176.362	0.000	1
357	2	28	MET	CA	C	54.669	0.000	1
358	2	28	MET	CB	C	35.331	0.000	1
359	2	28	MET	CG	C	29.007	0.000	1
360	2	28	MET	CE	C	17.479	0.000	1
361	2	28	MET	N	N	112.684	0.000	1
362	2	29	HIS	H	H	8.824	0.000	1
363	2	29	HIS	HB3	H	3.509	0.000	1
364	2	29	HIS	HD2	H	7.015	0.000	1
365	2	29	HIS	HE1	H	7.392	0.000	1
366	2	29	HIS	CB	C	32.179	0.000	1
367	2	29	HIS	CD2	C	117.815	0.000	1
368	2	29	HIS	CE1	C	138.101	0.000	1
369	2	29	HIS	N	N	118.433	0.000	1
370	2	30	ALA	H	H	9.118	0.000	1
371	2	30	ALA	HA	H	3.773	0.000	1
372	2	30	ALA	HB1	H	1.077	0.000	1
373	2	30	ALA	HB2	H	1.077	0.000	1
374	2	30	ALA	HB3	H	1.077	0.000	1
375	2	30	ALA	C	C	180.971	0.000	1
376	2	30	ALA	CA	C	55.352	0.000	1
377	2	30	ALA	CB	C	18.507	0.000	1
378	2	30	ALA	N	N	128.682	0.000	1
379	2	31	GLY	H	H	9.393	0.000	1
380	2	31	GLY	HA3	H	3.320	0.000	1
381	2	31	GLY	C	C	177.511	0.000	1
382	2	31	GLY	CA	C	46.711	0.000	1
383	2	31	GLY	N	N	105.144	0.000	1
384	2	32	CYS	H	H	7.025	0.000	1
385	2	32	CYS	HA	H	4.221	0.000	1
386	2	32	CYS	HB3	H	3.183	0.000	1
387	2	32	CYS	C	C	175.560	0.000	1
388	2	32	CYS	CA	C	63.831	0.000	1
389	2	32	CYS	CB	C	28.790	0.000	1
390	2	32	CYS	N	N	120.397	0.000	1
391	2	33	GLU	H	H	7.367	0.000	1
392	2	33	GLU	HA	H	4.495	0.000	1
393	2	33	GLU	HB3	H	1.387	0.000	1
394	2	33	GLU	HG3	H	1.996	0.000	1
395	2	33	GLU	C	C	174.385	0.000	1
396	2	33	GLU	CB	C	29.648	0.000	1
397	2	33	GLU	CG	C	35.715	0.000	1
398	2	33	GLU	N	N	120.992	0.000	1
399	2	34	SER	H	H	7.385	0.000	1
400	2	34	SER	HA	H	3.499	0.000	1
401	2	34	SER	HB3	H	3.999	0.000	1
402	2	34	SER	C	C	172.067	0.000	1
403	2	34	SER	CA	C	58.918	0.000	1
404	2	34	SER	CB	C	60.781	0.000	1
405	2	34	SER	N	N	108.464	0.000	1
406	2	35	LEU	H	H	7.304	0.000	1
407	2	35	LEU	HA	H	4.309	0.000	1
408	2	35	LEU	HB3	H	1.441	0.000	1
409	2	35	LEU	HG	H	1.392	0.000	1
410	2	35	LEU	HD21	H	0.442	0.000	1
411	2	35	LEU	HD22	H	0.442	0.000	1
412	2	35	LEU	HD23	H	0.442	0.000	1
413	2	35	LEU	C	C	175.934	0.000	1
414	2	35	LEU	CA	C	53.212	0.000	1
415	2	35	LEU	CB	C	43.771	0.000	1
416	2	35	LEU	CG	C	25.531	0.000	1
417	2	35	LEU	CD1	C	27.120	0.000	1
418	2	35	LEU	CD2	C	23.710	0.000	1
419	2	35	LEU	N	N	120.411	0.000	1
420	2	36	PHE	H	H	8.699	0.000	1
421	2	36	PHE	HA	H	4.313	0.000	1
422	2	36	PHE	HB3	H	3.421	0.000	1
423	2	36	PHE	HD1	H	7.254	0.000	1
424	2	36	PHE	HD2	H	7.254	0.000	1
425	2	36	PHE	HE1	H	7.337	0.000	1
426	2	36	PHE	HE2	H	7.337	0.000	1
427	2	36	PHE	C	C	175.784	0.000	1
428	2	36	PHE	CB	C	41.318	0.000	1
429	2	36	PHE	CD1	C	131.653	0.000	1
430	2	36	PHE	CD2	C	131.653	0.000	1
431	2	36	PHE	CE1	C	131.566	0.000	1
432	2	36	PHE	CE2	C	131.566	0.000	1
433	2	36	PHE	N	N	118.127	0.000	1
434	2	37	THR	H	H	7.567	0.000	1
435	2	37	THR	HA	H	4.768	0.000	1
436	2	37	THR	HB	H	4.584	0.000	1
437	2	37	THR	HG21	H	1.248	0.000	1
438	2	37	THR	HG22	H	1.248	0.000	1
439	2	37	THR	HG23	H	1.248	0.000	1
440	2	37	THR	C	C	174.488	0.000	1
441	2	37	THR	CB	C	72.632	0.000	1
442	2	37	THR	CG2	C	21.586	0.000	1
443	2	37	THR	N	N	107.946	0.000	1
444	2	38	GLU	H	H	9.258	0.000	1
445	2	38	GLU	HA	H	3.778	0.000	1
446	2	38	GLU	HB3	H	2.032	0.000	1
447	2	38	GLU	HG3	H	2.316	0.000	1
448	2	38	GLU	C	C	178.056	0.000	1
449	2	38	GLU	CA	C	60.454	0.000	1
450	2	38	GLU	CG	C	37.219	0.000	1
451	2	38	GLU	N	N	122.398	0.000	1
452	2	39	ASP	H	H	8.353	0.000	1
453	2	39	ASP	HA	H	4.369	0.000	1
454	2	39	ASP	HB3	H	2.531	0.000	1
455	2	39	ASP	C	C	178.236	0.000	1
456	2	39	ASP	CA	C	57.091	0.000	1
457	2	39	ASP	CB	C	40.650	0.000	1
458	2	39	ASP	N	N	117.908	0.000	1
459	2	40	ASP	H	H	7.873	0.000	1
460	2	40	ASP	HA	H	4.366	0.000	1
461	2	40	ASP	HB3	H	2.637	0.000	1
462	2	40	ASP	C	C	179.020	0.000	1
463	2	40	ASP	CA	C	57.005	0.000	1
464	2	40	ASP	CB	C	40.822	0.000	1
465	2	40	ASP	N	N	119.681	0.000	1
466	2	41	VAL	H	H	7.880	0.000	1
467	2	41	VAL	HA	H	3.408	0.000	1
468	2	41	VAL	HB	H	2.062	0.000	1
469	2	41	VAL	HG11	H	0.780	0.000	1
470	2	41	VAL	HG12	H	0.780	0.000	1
471	2	41	VAL	HG13	H	0.780	0.000	1
472	2	41	VAL	HG21	H	0.780	0.000	1
473	2	41	VAL	HG22	H	0.780	0.000	1
474	2	41	VAL	HG23	H	0.780	0.000	1
475	2	41	VAL	C	C	176.458	0.000	1
476	2	41	VAL	CA	C	66.720	0.000	1
477	2	41	VAL	CB	C	31.946	0.000	1
478	2	41	VAL	CG1	C	25.485	0.000	1
479	2	41	VAL	CG2	C	21.727	0.000	1
480	2	41	VAL	N	N	120.964	0.000	1
481	2	42	GLU	H	H	8.396	0.000	1
482	2	42	GLU	HA	H	3.801	0.000	1
483	2	42	GLU	HB3	H	2.056	0.000	1
484	2	42	GLU	HG3	H	2.379	0.000	1
485	2	42	GLU	C	C	178.868	0.000	1
486	2	42	GLU	CB	C	29.440	0.000	1
487	2	42	GLU	CG	C	36.538	0.000	1
488	2	42	GLU	N	N	119.601	0.000	1
489	2	43	GLN	H	H	7.969	0.000	1
490	2	43	GLN	HA	H	4.088	0.000	1
491	2	43	GLN	HB3	H	2.089	0.000	1
492	2	43	GLN	HG3	H	2.353	0.000	1
493	2	43	GLN	HE21	H	6.766	0.000	1
494	2	43	GLN	HE22	H	7.671	0.000	1
495	2	43	GLN	C	C	177.938	0.000	1
496	2	43	GLN	CA	C	58.872	0.000	1
497	2	43	GLN	CB	C	28.591	0.000	1
498	2	43	GLN	CG	C	33.837	0.000	1
499	2	43	GLN	N	N	117.557	0.000	1
500	2	43	GLN	NE2	N	112.393	0.000	1
501	2	44	ALA	H	H	7.882	0.000	1
502	2	44	ALA	HA	H	4.131	0.000	1
503	2	44	ALA	HB1	H	1.382	0.000	1
504	2	44	ALA	HB2	H	1.382	0.000	1
505	2	44	ALA	HB3	H	1.382	0.000	1
506	2	44	ALA	C	C	180.129	0.000	1
507	2	44	ALA	CA	C	54.771	0.000	1
508	2	44	ALA	CB	C	18.855	0.000	1
509	2	44	ALA	N	N	121.806	0.000	1
510	2	45	ALA	H	H	8.547	0.000	1
511	2	45	ALA	HA	H	4.163	0.000	1
512	2	45	ALA	HB1	H	1.437	0.000	1
513	2	45	ALA	HB2	H	1.437	0.000	1
514	2	45	ALA	HB3	H	1.437	0.000	1
515	2	45	ALA	C	C	180.792	0.000	1
516	2	45	ALA	CA	C	54.259	0.000	1
517	2	45	ALA	CB	C	18.210	0.000	1
518	2	45	ALA	N	N	119.406	0.000	1
519	2	46	ASP	H	H	8.195	0.000	1
520	2	46	ASP	HA	H	4.389	0.000	1
521	2	46	ASP	HB3	H	2.855	0.000	1
522	2	46	ASP	C	C	178.155	0.000	1
523	2	46	ASP	CA	C	56.819	0.000	1
524	2	46	ASP	CB	C	41.384	0.000	1
525	2	46	ASP	N	N	119.076	0.000	1
526	2	47	GLU	H	H	7.994	0.000	1
527	2	47	GLU	HA	H	4.134	0.000	1
528	2	47	GLU	HB3	H	2.078	0.000	1
529	2	47	GLU	HG3	H	2.364	0.000	1
530	2	47	GLU	C	C	176.911	0.000	1
531	2	47	GLU	CA	C	57.966	0.000	1
532	2	47	GLU	CB	C	30.094	0.000	1
533	2	47	GLU	CG	C	36.545	0.000	1
534	2	47	GLU	N	N	117.542	0.000	1
535	2	48	GLY	H	H	7.549	0.000	1
536	2	48	GLY	HA3	H	3.446	0.000	1
537	2	48	GLY	CA	C	45.201	0.000	1
538	2	48	GLY	N	N	109.011	0.000	1
539	2	49	PHE	H	H	8.967	0.000	1
540	2	49	PHE	HA	H	4.579	0.000	1
541	2	49	PHE	HB3	H	2.692	0.000	1
542	2	49	PHE	HD1	H	7.081	0.000	1
543	2	49	PHE	HD2	H	7.081	0.000	1
544	2	49	PHE	HE1	H	7.075	0.000	1
545	2	49	PHE	HE2	H	7.075	0.000	1
546	2	49	PHE	HZ	H	7.190	0.000	1
547	2	49	PHE	C	C	171.936	0.000	1
548	2	49	PHE	CA	C	56.348	0.000	1
549	2	49	PHE	CB	C	40.451	0.000	1
550	2	49	PHE	CD1	C	131.951	0.000	1
551	2	49	PHE	CD2	C	131.951	0.000	1
552	2	49	PHE	CE1	C	130.890	0.000	1
553	2	49	PHE	CE2	C	130.890	0.000	1
554	2	49	PHE	CZ	C	129.814	0.000	1
555	2	49	PHE	N	N	129.561	0.000	1
556	2	50	ASP	H	H	7.296	0.000	1
557	2	50	ASP	HA	H	5.585	0.000	1
558	2	50	ASP	HB3	H	2.109	0.000	1
559	2	50	ASP	C	C	174.604	0.000	1
560	2	50	ASP	CA	C	51.725	0.000	1
561	2	50	ASP	CB	C	44.082	0.000	1
562	2	50	ASP	N	N	126.375	0.000	1
563	2	51	CYS	H	H	9.631	0.000	1
564	2	51	CYS	HA	H	4.283	0.000	1
565	2	51	CYS	HB3	H	3.596	0.000	1
566	2	51	CYS	CA	C	57.918	0.000	1
567	2	51	CYS	CB	C	32.713	0.000	1
568	2	51	CYS	N	N	127.323	0.000	1
569	2	52	VAL	H	H	9.915	0.000	1
570	2	52	VAL	HA	H	3.731	0.000	1
571	2	52	VAL	HB	H	2.286	0.000	1
572	2	52	VAL	HG11	H	1.075	0.000	1
573	2	52	VAL	HG12	H	1.075	0.000	1
574	2	52	VAL	HG13	H	1.075	0.000	1
575	2	52	VAL	HG21	H	1.075	0.000	1
576	2	52	VAL	HG22	H	1.075	0.000	1
577	2	52	VAL	HG23	H	1.075	0.000	1
578	2	52	VAL	C	C	178.060	0.000	1
579	2	52	VAL	CA	C	65.928	0.000	1
580	2	52	VAL	CB	C	31.640	0.000	1
581	2	52	VAL	CG1	C	22.107	0.000	1
582	2	52	VAL	CG2	C	20.838	0.000	1
583	2	52	VAL	N	N	120.944	0.000	1
584	2	53	SER	H	H	8.270	0.000	1
585	2	53	SER	HA	H	4.320	0.000	1
586	2	53	SER	HB3	H	3.955	0.000	1
587	2	53	SER	C	C	175.694	0.000	1
588	2	53	SER	CA	C	61.095	0.000	1
589	2	53	SER	CB	C	63.259	0.000	1
590	2	53	SER	N	N	117.338	0.000	1
591	2	54	CYS	H	H	8.053	0.000	1
592	2	54	CYS	HA	H	4.154	0.000	1
593	2	54	CYS	HB3	H	2.752	0.000	1
594	2	54	CYS	C	C	175.988	0.000	1
595	2	54	CYS	CA	C	62.394	0.000	1
596	2	54	CYS	CB	C	29.828	0.000	1
597	2	54	CYS	N	N	122.601	0.000	1
598	2	55	GLN	H	H	7.787	0.000	1
599	2	55	GLN	HA	H	3.894	0.000	1
600	2	55	GLN	HB3	H	2.006	0.000	1
601	2	55	GLN	HG3	H	2.358	0.000	1
602	2	55	GLN	HE21	H	7.155	0.000	1
603	2	55	GLN	HE22	H	6.780	0.000	1
604	2	55	GLN	CA	C	58.330	0.000	1
605	2	55	GLN	CB	C	27.303	0.000	1
606	2	55	GLN	CG	C	34.139	0.000	1
607	2	55	GLN	N	N	119.841	0.000	1
608	2	55	GLN	NE2	N	113.080	0.000	1
609	2	56	PRO	HA	H	4.224	0.000	1
610	2	56	PRO	HB3	H	1.051	0.000	1
611	2	56	PRO	HG3	H	1.774	0.000	1
612	2	56	PRO	HD3	H	3.560	0.000	1
613	2	56	PRO	C	C	176.683	0.000	1
614	2	56	PRO	CA	C	64.647	0.000	1
615	2	56	PRO	CB	C	31.209	0.000	1
616	2	56	PRO	CG	C	27.618	0.000	1
617	2	56	PRO	CD	C	50.650	0.000	1
618	2	57	TYR	H	H	7.794	0.000	1
619	2	57	TYR	HA	H	4.474	0.000	1
620	2	57	TYR	HB3	H	3.139	0.000	1
621	2	57	TYR	HD1	H	7.058	0.000	1
622	2	57	TYR	HD2	H	7.058	0.000	1
623	2	57	TYR	HE1	H	6.841	0.000	1
624	2	57	TYR	HE2	H	6.841	0.000	1
625	2	57	TYR	CA	C	57.284	0.000	1
626	2	57	TYR	CB	C	38.667	0.000	1
627	2	57	TYR	CD1	C	133.079	0.000	1
628	2	57	TYR	CD2	C	133.079	0.000	1
629	2	57	TYR	CE1	C	118.352	0.000	1
630	2	57	TYR	CE2	C	118.352	0.000	1
631	2	57	TYR	N	N	115.923	0.000	1
632	2	58	VAL	H	H	7.413	0.000	1
633	2	58	VAL	HA	H	3.942	0.000	1
634	2	58	VAL	HB	H	1.898	0.000	1
635	2	58	VAL	HG11	H	0.674	0.000	1
636	2	58	VAL	HG12	H	0.674	0.000	1
637	2	58	VAL	HG13	H	0.674	0.000	1
638	2	58	VAL	HG21	H	0.674	0.000	1
639	2	58	VAL	HG22	H	0.674	0.000	1
640	2	58	VAL	HG23	H	0.674	0.000	1
641	2	58	VAL	CA	C	62.189	0.000	1
642	2	58	VAL	CB	C	32.892	0.000	1
643	2	58	VAL	CG1	C	20.013	0.000	1
644	2	58	VAL	CG2	C	20.873	0.000	1
645	2	58	VAL	N	N	120.177	0.000	1
646	2	59	VAL	HA	H	4.006	0.000	1
647	2	59	VAL	HB	H	1.996	0.000	1
648	2	59	VAL	HG11	H	0.912	0.000	1
649	2	59	VAL	HG12	H	0.912	0.000	1
650	2	59	VAL	HG13	H	0.912	0.000	1
651	2	59	VAL	HG21	H	0.912	0.000	1
652	2	59	VAL	HG22	H	0.912	0.000	1
653	2	59	VAL	HG23	H	0.912	0.000	1
654	2	59	VAL	CA	C	62.514	0.000	1
655	2	59	VAL	CB	C	32.766	0.000	1
656	2	59	VAL	CG1	C	20.772	0.000	1
657	2	59	VAL	N	N	125.507	0.000	1
658	2	60	LYS	H	H	7.966	0.000	1
659	2	60	LYS	HA	H	4.145	0.000	1
660	2	60	LYS	HB3	H	1.767	0.000	1
661	2	60	LYS	HG3	H	1.342	0.000	1
662	2	60	LYS	HD3	H	1.620	0.000	1
663	2	60	LYS	HE3	H	2.938	0.000	1
664	2	60	LYS	CA	C	57.547	0.000	1
665	2	60	LYS	CB	C	33.864	0.000	1
666	2	60	LYS	CG	C	24.714	0.000	1
667	2	60	LYS	CD	C	29.164	0.000	1
668	2	60	LYS	CE	C	42.116	0.000	1
669	2	60	LYS	N	N	131.429	0.000	1

Release date

2023-10-08

Citation

MLL4 binds TET3
Becht, D.C., Mohid, S.A., Lee, J.E., Zandian, M., Benz, C., Biswas, S., Sinha, V.K., Ivarsson, Y., Ge, K., Zhang, Y., Kutateladze, T.G.
Structure (2024), 32, 706-714, PubMed 38579707 , DOI 10.1016/j.str.2024.03.005 , Abstract

Related entities 1. Methylcytosine dioxygenase TET3 (E.C.1.14.11.80), Histone-lysine N-methyltransferase 2D (E.C.2.1.1.364), entity 1, : 2 entities Detail

Related entities 2. Methylcytosine dioxygenase TET3 (E.C.1.14.11.80), Histone-lysine N-methyltransferase 2D (E.C.2.1.1.364), entity 2, : 1 : 2 : 1 : 81 entities Detail

Interaction partners 1. Methylcytosine dioxygenase TET3 (E.C.1.14.11.80), Histone-lysine N-methyltransferase 2D (E.C.2.1.1.364), entity 1, : 22 interactors Detail

Interaction partners 2. Methylcytosine dioxygenase TET3 (E.C.1.14.11.80), Histone-lysine N-methyltransferase 2D (E.C.2.1.1.364), entity 2, : 28 interactors Detail

Experiments performed 13 experiments Detail

Chemical shift validation 5 contents Detail