NMR ensemble of Macrocyclic Peptidomimetic Containing Constrained a,a-dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors
Polymer type: polypeptide(L)
Total | 1H | |
---|---|---|
All | 100.0 % (29 of 29) | 100.0 % (29 of 29) |
Backbone | 100.0 % (8 of 8) | 100.0 % (8 of 8) |
Sidechain | 100.0 % (21 of 21) | 100.0 % (21 of 21) |
Aromatic | 100.0 % (8 of 8) | 100.0 % (8 of 8) |
1. entity 1
XHXRWDXSolvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 298 K, pH 5.5, Details 2.0 mM Peptide, 10 % v/v [U-99% 2H] D2O, 0.1 mM TSP, 200 mM [U-100% 2H] DPC, 90% H2O/10% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | Peptide | natural abundance | 2.0 mM | |
2 | D2O | [U-99% 2H] | 10 % v/v | |
3 | TSP | natural abundance | 0.1 mM | |
4 | DPC | [U-100% 2H] | 200 mM |