BMRB: 34264

exendin-4 based dual GLP-1/glucagon receptor agonist

Authors

Evers, A., Kurz, M.

Assembly

Exendin-4

Entity

1. Exendin-4, entity 1 (polymer, Thiol state: not present), 40 monomers, 4137.544 Da Detail

HXQGTFTSDL SKQKDEQRAK LFIEWLXAGG PSSGAPPPSX

2. Exendin-4, entity EVT (non-polymer), 514.652 Da

Total weight

4652.196 Da

Max. entity weight

4137.544 Da

Source organism

Heloderma suspectum

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 92.5 %, Completeness: 97.3 %, Completeness (bb): 94.6 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	97.3 % (216 of 222)	97.3 % (216 of 222)
Backbone	94.6 % (70 of 74)	94.6 % (70 of 74)
Sidechain	98.6 % (146 of 148)	98.6 % (146 of 148)
Aromatic	100.0 % (18 of 18)	100.0 % (18 of 18)
Methyl	100.0 % (13 of 13)	100.0 % (13 of 13)

1. entity 1

HXQGTFTSDL SKQKDEQRAK LFIEWLXAGG PSSGAPPPSX

Show sample condition

Sample

Solvent system trifluoroethanol/water, Pressure 1 (±0.01) Pa, Temperature 310 (±0.2) K, pH 5.0 (±0.05), Details 5 mg/mL Peptide 5, trifluoroethanol/water

#	Name	Isotope labeling	Type	Concentration
1	Peptide 5	natural abundance		5 mg/mL
2	sodium phosphate	natural abundance		35 mM

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Release date

2018-06-17

Citation

Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations
Evers, A., Bossart, M., Pfeiffer-Marek, S., Elvert, R., Schreuder, H.A., Kurz, M., Stengelin, S., Lorenz, M., Herling, A., Konkar, A.A., Lukasczyk, U., Pfenninger, A., Lorenz, K., Haack, T., Kadereit, D., Wagner, M.
J. Med. Chem. (2018), 61, 5580-5593, PubMed 29879354 , DOI 10.1021/acs.jmedchem.8b00292 , Abstract

Related entities 1. Exendin-4, entity 1, : 1 : 39 entities Detail

Experiments performed 4 experiments Detail