BMRB: 34317

Structure of human SRSF1 RRM1 bound to AACAAA RNA

Authors

Allain, F.T.H., Clery, A.

Assembly

Immunoglobulin G-binding protein G,Serine/arginine-rich splicing factor 1/RNA Complex

Entity

1. Immunoglobulin G-binding protein G,Serine/arginine-rich splicing factor 1/RNA Complex, entity 1 (polymer), 161 monomers, 17928.45 Da Detail

MQYKLILNGK TLKGETTTEA VDAATAEKVF KQYANDNGVD GEWTYDDATK TFTVTEGSHH HHHHMSGGGV IRGPAGNNDC RIYVGNLPPD IRTKDIEDVF SKYGAIRDID LKNRRGGPPF AFVEFEDPRD AEDAVSGRDG YDYDGYRLRV EFPRSGRGTG R

2. Immunoglobulin G-binding protein G,Serine/arginine-rich splicing factor 1/RNA Complex, entity 2 (polymer, Thiol state: not present), 6 monomers, 1969.226 Da Detail

AACAAA

Total weight

19897.676 Da

Max. entity weight

17928.45 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Refine. method

simulated annealing

Data set

assigned_chemical_shifts

Chemcal Shifts

¹H: 557, ¹³C: 213, ¹⁵N: 74 assignments Detail

Download

• NMR-STAR v3.1 (partial)
• BMRB/XML (partial)
• CSV
• TSV

ID	Entity ID	Seq ID	Comp ID	Atom ID	Atom type	Val	Val err	Ambig. code
1	1	71	ILE	H	H	8.302	0.001
2	1	71	ILE	HA	H	4.193	0.020
3	1	71	ILE	HB	H	1.862	0.003
4	1	71	ILE	HG12	H	1.183	0.007
5	1	71	ILE	HG13	H	1.492	0.017
6	1	71	ILE	HG21	H	0.882	0.007
7	1	71	ILE	HG22	H	0.882	0.007
8	1	71	ILE	HG23	H	0.882	0.007
9	1	71	ILE	HD11	H	0.856	0.023
10	1	71	ILE	HD12	H	0.856	0.023
11	1	71	ILE	HD13	H	0.856	0.023
12	1	71	ILE	CA	C	60.904	0.003
13	1	71	ILE	CB	C	38.473	0.010
14	1	71	ILE	CG1	C	27.346	0.008
15	1	71	ILE	CG2	C	17.549	0.002
16	1	71	ILE	CD1	C	12.732	0.025
17	1	71	ILE	N	N	125.689	0.067
18	1	72	ARG	H	H	8.415	0.001
19	1	72	ARG	HA	H	4.428	0.000
20	1	72	ARG	HB2	H	1.828	0.057
21	1	72	ARG	HB3	H	1.827	0.058
22	1	72	ARG	HG2	H	1.694	0.000
23	1	72	ARG	HG3	H	1.694	0.000
24	1	72	ARG	HD2	H	3.173	0.010
25	1	72	ARG	HD3	H	3.173	0.010
26	1	72	ARG	CB	C	31.099	0.040
27	1	72	ARG	N	N	126.038	0.056
28	1	73	GLY	H	H	8.306	0.000
29	1	73	GLY	HA2	H	4.070	0.000
30	1	73	GLY	HA3	H	4.070	0.000
31	1	73	GLY	N	N	109.502	0.000
32	1	74	PRO	HG2	H	1.962	0.014
33	1	74	PRO	HG3	H	1.962	0.014
34	1	74	PRO	HD2	H	3.540	0.000
35	1	74	PRO	HD3	H	3.612	0.000
36	1	74	PRO	CD	C	49.886	0.057
37	1	75	ALA	H	H	8.481	0.003
38	1	75	ALA	HA	H	4.327	0.012
39	1	75	ALA	HB1	H	1.417	0.008
40	1	75	ALA	HB2	H	1.417	0.008
41	1	75	ALA	HB3	H	1.417	0.008
42	1	75	ALA	CA	C	52.701	0.000
43	1	75	ALA	CB	C	19.195	0.024
44	1	75	ALA	N	N	123.883	0.000
45	1	76	GLY	H	H	8.323	0.000
46	1	76	GLY	HA2	H	4.036	0.006
47	1	76	GLY	HA3	H	4.036	0.006
48	1	76	GLY	N	N	107.519	0.000
49	1	77	ASN	HB2	H	2.745	0.000
50	1	77	ASN	HB3	H	2.844	0.000
51	1	77	ASN	HD21	H	7.608	0.001
52	1	77	ASN	HD22	H	6.889	0.001
53	1	77	ASN	ND2	N	113.181	0.053
54	1	78	ASN	HB2	H	2.760	0.000
55	1	78	ASN	HB3	H	2.868	0.000
56	1	78	ASN	HD21	H	7.519	0.000
57	1	78	ASN	HD22	H	6.983	0.000
58	1	78	ASN	ND2	N	113.097	0.007
59	1	79	ASP	H	H	8.388	0.035
60	1	79	ASP	HA	H	4.691	0.012
61	1	79	ASP	HB2	H	2.717	0.018
62	1	79	ASP	HB3	H	2.845	0.010
63	1	79	ASP	CB	C	41.078	0.037
64	1	79	ASP	N	N	120.236	0.009
65	1	80	CYS	H	H	8.360	0.016
66	1	80	CYS	HA	H	4.548	0.000
67	1	80	CYS	HB2	H	3.120	0.008
68	1	80	CYS	HB3	H	3.534	0.005
69	1	80	CYS	CB	C	29.441	0.005
70	1	80	CYS	N	N	115.571	0.004
71	1	81	ARG	H	H	7.750	0.003
72	1	81	ARG	HA	H	5.401	0.013
73	1	81	ARG	HB2	H	1.774	0.018
74	1	81	ARG	HB3	H	1.951	0.010
75	1	81	ARG	HG2	H	1.563	0.007
76	1	81	ARG	HG3	H	1.563	0.007
77	1	81	ARG	HD2	H	3.149	0.000
78	1	81	ARG	HD3	H	3.180	0.000
79	1	81	ARG	CA	C	55.343	0.000
80	1	81	ARG	CB	C	33.377	0.065
81	1	81	ARG	CG	C	28.439	0.000
82	1	81	ARG	N	N	121.968	0.003
83	1	82	ILE	H	H	9.053	0.024
84	1	82	ILE	HA	H	4.874	0.006
85	1	82	ILE	HB	H	1.560	0.030
86	1	82	ILE	HG12	H	1.168	0.015
87	1	82	ILE	HG13	H	1.168	0.015
88	1	82	ILE	HG21	H	0.534	0.024
89	1	82	ILE	HG22	H	0.534	0.024
90	1	82	ILE	HG23	H	0.534	0.024
91	1	82	ILE	HD11	H	0.336	0.016
92	1	82	ILE	HD12	H	0.336	0.016
93	1	82	ILE	HD13	H	0.336	0.016
94	1	82	ILE	CA	C	59.451	0.021
95	1	82	ILE	CB	C	40.618	0.009
96	1	82	ILE	CG1	C	27.355	0.000
97	1	82	ILE	CG2	C	18.798	0.012
98	1	82	ILE	CD1	C	14.599	0.006
99	1	82	ILE	N	N	116.071	0.007
100	1	83	TYR	H	H	9.115	0.001
101	1	83	TYR	HA	H	4.842	0.039
102	1	83	TYR	HB2	H	2.671	0.012
103	1	83	TYR	HB3	H	2.785	0.076
104	1	83	TYR	HD1	H	6.534	0.028
105	1	83	TYR	HD2	H	6.534	0.028
106	1	83	TYR	HE1	H	6.149	0.005
107	1	83	TYR	HE2	H	6.149	0.005
108	1	83	TYR	CD1	C	132.862	0.007
109	1	83	TYR	CE1	C	117.949	0.000
110	1	83	TYR	N	N	123.883	0.037
111	1	84	VAL	H	H	8.347	0.029
112	1	84	VAL	HA	H	4.767	0.033
113	1	84	VAL	HB	H	1.750	0.012
114	1	84	VAL	HG11	H	0.618	0.003
115	1	84	VAL	HG12	H	0.618	0.003
116	1	84	VAL	HG13	H	0.618	0.003
117	1	84	VAL	HG21	H	0.928	0.011
118	1	84	VAL	HG22	H	0.928	0.011
119	1	84	VAL	HG23	H	0.928	0.011
120	1	84	VAL	CB	C	33.580	0.007
121	1	84	VAL	CG1	C	21.815	0.001
122	1	84	VAL	CG2	C	21.868	0.000
123	1	84	VAL	N	N	126.438	0.006
124	1	85	GLY	H	H	9.486	0.014
125	1	85	GLY	HA2	H	3.685	0.011
126	1	85	GLY	HA3	H	4.670	0.004
127	1	85	GLY	CA	C	43.208	0.019
128	1	85	GLY	N	N	113.431	0.004
129	1	86	ASN	H	H	9.081	0.009
130	1	86	ASN	HA	H	4.280	0.019
131	1	86	ASN	HB2	H	2.456	0.002
132	1	86	ASN	HB3	H	3.973	0.003
133	1	86	ASN	HD21	H	6.793	0.000
134	1	86	ASN	HD22	H	8.221	0.000
135	1	86	ASN	CA	C	53.961	0.014
136	1	86	ASN	CB	C	38.455	0.013
137	1	86	ASN	N	N	116.044	0.002
138	1	86	ASN	ND2	N	111.706	0.009
139	1	87	LEU	H	H	6.644	0.001
140	1	87	LEU	HA	H	4.117	0.005
141	1	87	LEU	HB2	H	1.085	0.002
142	1	87	LEU	HB3	H	1.327	0.004
143	1	87	LEU	HD11	H	0.736	0.004
144	1	87	LEU	HD12	H	0.736	0.004
145	1	87	LEU	HD13	H	0.736	0.004
146	1	87	LEU	HD21	H	0.531	0.000
147	1	87	LEU	HD22	H	0.531	0.000
148	1	87	LEU	HD23	H	0.531	0.000
149	1	87	LEU	CA	C	52.865	0.000
150	1	87	LEU	CB	C	41.930	0.030
151	1	87	LEU	CD1	C	23.635	0.000
152	1	87	LEU	CD2	C	26.386	0.000
153	1	87	LEU	N	N	111.963	0.004
154	1	88	PRO	HG2	H	1.800	0.000
155	1	88	PRO	HG3	H	1.946	0.000
156	1	88	PRO	HD2	H	3.188	0.000
157	1	88	PRO	HD3	H	3.432	0.000
158	1	88	PRO	CD	C	49.347	0.004
159	1	89	PRO	HA	H	4.024	0.000
160	1	89	PRO	HB2	H	2.320	0.000
161	1	89	PRO	HB3	H	2.320	0.000
162	1	89	PRO	HG2	H	2.055	0.000
163	1	89	PRO	HG3	H	2.055	0.000
164	1	89	PRO	HD2	H	3.503	0.004
165	1	89	PRO	HD3	H	3.503	0.004
166	1	89	PRO	CA	C	64.562	0.000
167	1	89	PRO	CB	C	32.088	0.000
168	1	89	PRO	CG	C	27.696	0.000
169	1	89	PRO	CD	C	50.733	0.000
170	1	90	ASP	H	H	8.156	0.004
171	1	90	ASP	HA	H	4.666	0.006
172	1	90	ASP	HB2	H	2.713	0.001
173	1	90	ASP	HB3	H	2.798	0.004
174	1	90	ASP	CB	C	39.880	0.059
175	1	90	ASP	N	N	115.132	0.001
176	1	91	ILE	H	H	7.167	0.005
177	1	91	ILE	HA	H	4.103	0.004
178	1	91	ILE	HB	H	1.933	0.006
179	1	91	ILE	HG12	H	1.248	0.004
180	1	91	ILE	HG13	H	1.734	0.009
181	1	91	ILE	HG21	H	0.778	0.002
182	1	91	ILE	HG22	H	0.778	0.002
183	1	91	ILE	HG23	H	0.778	0.002
184	1	91	ILE	HD11	H	0.837	0.001
185	1	91	ILE	HD12	H	0.837	0.001
186	1	91	ILE	HD13	H	0.837	0.001
187	1	91	ILE	CA	C	59.673	0.003
188	1	91	ILE	CB	C	39.333	0.013
189	1	91	ILE	CG1	C	29.200	0.032
190	1	91	ILE	CG2	C	19.873	0.006
191	1	91	ILE	CD1	C	15.793	0.005
192	1	91	ILE	N	N	120.426	0.002
193	1	92	ARG	H	H	8.451	0.005
194	1	92	ARG	HA	H	4.857	0.001
195	1	92	ARG	HB2	H	1.735	0.000
196	1	92	ARG	HB3	H	1.735	0.000
197	1	92	ARG	HG2	H	1.821	0.001
198	1	92	ARG	HG3	H	1.821	0.001
199	1	92	ARG	HD2	H	3.365	0.000
200	1	92	ARG	HD3	H	3.365	0.000
201	1	92	ARG	CA	C	53.668	0.000
202	1	92	ARG	CB	C	29.181	0.000
203	1	92	ARG	CG	C	26.405	0.000
204	1	92	ARG	CD	C	43.470	0.000
205	1	92	ARG	N	N	123.540	0.000
206	1	93	THR	H	H	7.053	0.000
207	1	93	THR	HA	H	4.172	0.009
208	1	93	THR	HB	H	3.653	0.004
209	1	93	THR	HG21	H	1.277	0.011
210	1	93	THR	HG22	H	1.277	0.011
211	1	93	THR	HG23	H	1.277	0.011
212	1	93	THR	CA	C	67.907	0.000
213	1	93	THR	CB	C	67.948	0.000
214	1	93	THR	CG2	C	23.184	0.000
215	1	93	THR	N	N	117.011	0.011
216	1	94	LYS	H	H	8.206	0.025
217	1	94	LYS	HA	H	4.157	0.007
218	1	94	LYS	HB2	H	1.665	0.000
219	1	94	LYS	HB3	H	1.925	0.005
220	1	94	LYS	HG2	H	1.492	0.006
221	1	94	LYS	HG3	H	1.492	0.006
222	1	94	LYS	HD2	H	1.659	0.008
223	1	94	LYS	HD3	H	1.659	0.008
224	1	94	LYS	HE2	H	3.024	0.010
225	1	94	LYS	HE3	H	3.024	0.010
226	1	94	LYS	CA	C	58.685	0.000
227	1	94	LYS	CB	C	32.225	0.048
228	1	94	LYS	CG	C	24.458	0.065
229	1	94	LYS	CD	C	28.659	0.005
230	1	94	LYS	CE	C	42.999	0.000
231	1	94	LYS	N	N	119.352	0.006
232	1	95	ASP	H	H	7.053	0.001
233	1	95	ASP	HA	H	4.477	0.004
234	1	95	ASP	HB2	H	3.029	0.004
235	1	95	ASP	HB3	H	3.155	0.001
236	1	95	ASP	CA	C	57.402	0.000
237	1	95	ASP	CB	C	41.728	0.013
238	1	95	ASP	N	N	117.024	0.001
239	1	96	ILE	H	H	7.281	0.001
240	1	96	ILE	HA	H	3.568	0.011
241	1	96	ILE	HB	H	2.169	0.003
242	1	96	ILE	HG12	H	0.826	0.000
243	1	96	ILE	HG13	H	0.826	0.000
244	1	96	ILE	HG21	H	0.835	0.003
245	1	96	ILE	HG22	H	1.730	0.005
246	1	96	ILE	HG23	H	0.835	0.003
247	1	96	ILE	HD11	H	0.641	0.001
248	1	96	ILE	HD12	H	0.641	0.001
249	1	96	ILE	HD13	H	0.641	0.001
250	1	96	ILE	CA	C	64.881	0.000
251	1	96	ILE	CB	C	37.143	0.000
252	1	96	ILE	CG1	C	28.803	0.000
253	1	96	ILE	CG2	C	18.719	0.013
254	1	96	ILE	CD1	C	14.093	0.000
255	1	96	ILE	N	N	118.225	0.001
256	1	97	GLU	H	H	8.246	0.003
257	1	97	GLU	HA	H	3.721	0.003
258	1	97	GLU	HB2	H	2.130	0.000
259	1	97	GLU	HB3	H	2.254	0.000
260	1	97	GLU	HG2	H	2.243	0.010
261	1	97	GLU	HG3	H	2.243	0.010
262	1	97	GLU	CA	C	60.594	0.000
263	1	97	GLU	CB	C	29.624	0.007
264	1	97	GLU	CG	C	36.826	0.000
265	1	97	GLU	N	N	121.345	0.001
266	1	98	ASP	H	H	8.138	0.002
267	1	98	ASP	HA	H	4.468	0.010
268	1	98	ASP	HB2	H	2.785	0.003
269	1	98	ASP	HB3	H	3.001	0.003
270	1	98	ASP	CA	C	57.544	0.080
271	1	98	ASP	CB	C	40.551	0.051
272	1	98	ASP	N	N	118.759	0.004
273	1	99	VAL	H	H	7.717	0.002
274	1	99	VAL	HA	H	3.747	0.001
275	1	99	VAL	HB	H	1.931	0.003
276	1	99	VAL	HG11	H	0.003	0.001
277	1	99	VAL	HG12	H	0.003	0.001
278	1	99	VAL	HG13	H	0.003	0.001
279	1	99	VAL	HG21	H	0.873	0.003
280	1	99	VAL	HG22	H	0.873	0.003
281	1	99	VAL	HG23	H	0.873	0.003
282	1	99	VAL	CA	C	65.412	0.011
283	1	99	VAL	CB	C	32.318	0.023
284	1	99	VAL	CG1	C	21.323	0.011
285	1	99	VAL	CG2	C	23.093	0.007
286	1	99	VAL	N	N	118.586	0.017
287	1	100	PHE	H	H	7.932	0.002
288	1	100	PHE	HA	H	4.883	0.002
289	1	100	PHE	HB2	H	2.797	0.009
290	1	100	PHE	HB3	H	3.664	0.007
291	1	100	PHE	HD1	H	7.620	0.004
292	1	100	PHE	HD2	H	7.620	0.004
293	1	100	PHE	HE1	H	7.147	0.015
294	1	100	PHE	HE2	H	7.147	0.015
295	1	100	PHE	HZ	H	7.136	0.000
296	1	100	PHE	CA	C	61.223	0.012
297	1	100	PHE	CB	C	40.984	0.060
298	1	100	PHE	CD1	C	131.928	0.006
299	1	100	PHE	CE1	C	128.814	0.015
300	1	100	PHE	N	N	115.279	0.009
301	1	101	SER	H	H	8.822	0.002
302	1	101	SER	HA	H	4.556	0.008
303	1	101	SER	HB2	H	4.168	0.033
304	1	101	SER	HB3	H	4.212	0.002
305	1	101	SER	CA	C	61.720	0.000
306	1	101	SER	CB	C	62.891	0.008
307	1	101	SER	N	N	117.578	0.001
308	1	102	LYS	H	H	7.694	0.001
309	1	102	LYS	HA	H	4.046	0.002
310	1	102	LYS	HB2	H	1.323	0.002
311	1	102	LYS	HB3	H	1.545	0.001
312	1	102	LYS	HG2	H	0.505	0.002
313	1	102	LYS	HG3	H	0.900	0.000
314	1	102	LYS	HD2	H	1.357	0.017
315	1	102	LYS	HD3	H	1.357	0.017
316	1	102	LYS	HE2	H	2.738	0.002
317	1	102	LYS	HE3	H	2.738	0.002
318	1	102	LYS	CA	C	57.660	0.004
319	1	102	LYS	CB	C	31.418	0.011
320	1	102	LYS	CG	C	23.437	0.010
321	1	102	LYS	CD	C	28.827	0.025
322	1	102	LYS	CE	C	41.920	0.012
323	1	102	LYS	N	N	119.030	0.001
324	1	103	TYR	H	H	7.675	0.010
325	1	103	TYR	HA	H	4.267	0.010
326	1	103	TYR	HB2	H	2.886	0.010
327	1	103	TYR	HB3	H	3.258	0.003
328	1	103	TYR	HD1	H	7.416	0.001
329	1	103	TYR	HD2	H	7.416	0.001
330	1	103	TYR	HE1	H	6.662	0.003
331	1	103	TYR	HE2	H	6.662	0.003
332	1	103	TYR	CA	C	60.236	0.016
333	1	103	TYR	CB	C	38.481	0.030
334	1	103	TYR	CD1	C	132.878	0.008
335	1	103	TYR	CE1	C	118.471	0.037
336	1	103	TYR	N	N	116.995	0.003
337	1	104	GLY	H	H	7.305	0.003
338	1	104	GLY	HA2	H	3.816	0.003
339	1	104	GLY	HA3	H	4.846	0.008
340	1	104	GLY	CA	C	44.496	0.010
341	1	104	GLY	N	N	103.809	0.000
342	1	105	ALA	H	H	8.156	0.006
343	1	105	ALA	HA	H	4.312	0.004
344	1	105	ALA	HB1	H	1.421	0.003
345	1	105	ALA	HB2	H	1.421	0.003
346	1	105	ALA	HB3	H	1.421	0.003
347	1	105	ALA	CA	C	53.194	0.015
348	1	105	ALA	CB	C	19.173	0.000
349	1	105	ALA	N	N	119.737	0.000
350	1	106	ILE	H	H	8.480	0.003
351	1	106	ILE	HA	H	3.888	0.005
352	1	106	ILE	HB	H	1.604	0.004
353	1	106	ILE	HG12	H	1.747	0.009
354	1	106	ILE	HG13	H	0.052	0.001
355	1	106	ILE	HG21	H	0.512	0.004
356	1	106	ILE	HG22	H	0.512	0.004
357	1	106	ILE	HG23	H	0.512	0.004
358	1	106	ILE	HD11	H	0.644	0.003
359	1	106	ILE	HD12	H	0.644	0.003
360	1	106	ILE	HD13	H	0.644	0.003
361	1	106	ILE	CA	C	61.265	0.008
362	1	106	ILE	CB	C	40.259	0.018
363	1	106	ILE	CG1	C	28.264	0.028
364	1	106	ILE	CG2	C	18.049	0.006
365	1	106	ILE	CD1	C	14.161	0.034
366	1	106	ILE	N	N	123.876	0.009
367	1	107	ARG	H	H	9.252	0.009
368	1	107	ARG	HA	H	4.365	0.006
369	1	107	ARG	HB2	H	1.524	0.000
370	1	107	ARG	HB3	H	1.524	0.000
371	1	107	ARG	HG2	H	1.520	0.004
372	1	107	ARG	HG3	H	1.520	0.004
373	1	107	ARG	HD2	H	3.187	0.000
374	1	107	ARG	HD3	H	3.187	0.000
375	1	107	ARG	CA	C	56.975	0.003
376	1	107	ARG	CB	C	32.193	0.002
377	1	107	ARG	CG	C	27.129	0.003
378	1	107	ARG	CD	C	43.428	0.000
379	1	107	ARG	N	N	127.968	0.001
380	1	108	ASP	H	H	7.584	0.057
381	1	108	ASP	HA	H	4.734	0.084
382	1	108	ASP	HB2	H	2.337	0.014
383	1	108	ASP	HB3	H	2.650	0.010
384	1	108	ASP	CB	C	43.200	0.010
385	1	108	ASP	N	N	116.244	0.005
386	1	109	ILE	H	H	7.906	0.014
387	1	109	ILE	HA	H	4.410	0.010
388	1	109	ILE	HB	H	1.629	0.009
389	1	109	ILE	HG12	H	1.288	0.000
390	1	109	ILE	HG13	H	1.288	0.000
391	1	109	ILE	HG21	H	0.706	0.002
392	1	109	ILE	HG22	H	0.706	0.002
393	1	109	ILE	HG23	H	0.706	0.002
394	1	109	ILE	HD11	H	0.801	0.044
395	1	109	ILE	HD12	H	0.801	0.044
396	1	109	ILE	HD13	H	0.801	0.044
397	1	109	ILE	CA	C	61.566	0.000
398	1	109	ILE	CB	C	41.146	0.004
399	1	109	ILE	CG1	C	23.192	0.013
400	1	109	ILE	CG2	C	17.587	0.003
401	1	109	ILE	CD1	C	14.266	0.009
402	1	109	ILE	N	N	122.400	0.005
403	1	110	ASP	H	H	8.949	0.003
404	1	110	ASP	HA	H	4.922	0.004
405	1	110	ASP	HB2	H	2.629	0.007
406	1	110	ASP	HB3	H	3.065	0.008
407	1	110	ASP	CA	C	52.373	0.082
408	1	110	ASP	CB	C	42.543	0.008
409	1	110	ASP	N	N	128.958	0.002
410	1	111	LEU	H	H	8.263	0.010
411	1	111	LEU	HA	H	4.337	0.006
412	1	111	LEU	HB2	H	1.849	0.004
413	1	111	LEU	HB3	H	1.849	0.004
414	1	111	LEU	HG	H	0.722	0.008
415	1	111	LEU	HD11	H	0.573	0.012
416	1	111	LEU	HD12	H	0.573	0.012
417	1	111	LEU	HD13	H	0.573	0.012
418	1	111	LEU	HD21	H	0.733	0.000
419	1	111	LEU	HD22	H	0.733	0.000
420	1	111	LEU	HD23	H	0.733	0.000
421	1	111	LEU	CA	C	54.756	0.028
422	1	111	LEU	CB	C	43.982	0.030
423	1	111	LEU	CD1	C	23.529	0.004
424	1	111	LEU	CD2	C	26.423	0.003
425	1	111	LEU	N	N	126.169	0.010
426	1	112	LYS	H	H	8.994	0.009
427	1	112	LYS	HA	H	4.433	0.004
428	1	112	LYS	HB2	H	0.546	0.014
429	1	112	LYS	HB3	H	1.074	0.005
430	1	112	LYS	HG2	H	1.068	0.000
431	1	112	LYS	HG3	H	1.205	0.028
432	1	112	LYS	HD2	H	1.504	0.019
433	1	112	LYS	HD3	H	1.504	0.019
434	1	112	LYS	HE2	H	2.912	0.000
435	1	112	LYS	HE3	H	2.912	0.000
436	1	112	LYS	CA	C	54.188	0.033
437	1	112	LYS	CB	C	31.671	0.004
438	1	112	LYS	CG	C	24.599	0.007
439	1	112	LYS	CD	C	28.589	0.000
440	1	112	LYS	CE	C	42.086	0.000
441	1	112	LYS	N	N	129.139	0.007
442	1	113	ASN	H	H	8.007	0.011
443	1	113	ASN	HA	H	4.880	0.046
444	1	113	ASN	HB2	H	2.565	0.002
445	1	113	ASN	HB3	H	2.827	0.007
446	1	113	ASN	HD21	H	6.852	0.000
447	1	113	ASN	HD22	H	7.699	0.000
448	1	113	ASN	CA	C	52.687	0.000
449	1	113	ASN	CB	C	39.282	0.008
450	1	113	ASN	N	N	119.296	0.008
451	1	113	ASN	ND2	N	111.166	0.012
452	1	119	PRO	HA	H	4.804	0.005
453	1	119	PRO	HB2	H	2.208	0.003
454	1	119	PRO	HB3	H	2.208	0.003
455	1	119	PRO	HG2	H	1.981	0.001
456	1	119	PRO	HG3	H	1.981	0.001
457	1	119	PRO	HD2	H	3.816	0.083
458	1	119	PRO	HD3	H	3.845	0.084
459	1	119	PRO	CB	C	31.778	0.035
460	1	119	PRO	CG	C	27.517	0.005
461	1	119	PRO	CD	C	50.782	0.010
462	1	120	PHE	H	H	7.633	0.011
463	1	120	PHE	HA	H	5.168	0.002
464	1	120	PHE	HB2	H	2.734	0.007
465	1	120	PHE	HB3	H	3.190	0.007
466	1	120	PHE	HD1	H	6.908	0.015
467	1	120	PHE	HD2	H	6.908	0.015
468	1	120	PHE	HE1	H	7.308	0.012
469	1	120	PHE	HE2	H	7.308	0.012
470	1	120	PHE	HZ	H	7.324	0.000
471	1	120	PHE	CA	C	54.986	0.018
472	1	120	PHE	CB	C	41.622	0.043
473	1	120	PHE	CD1	C	132.991	0.024
474	1	120	PHE	CE1	C	131.062	0.000
475	1	120	PHE	CZ	C	129.643	0.000
476	1	120	PHE	N	N	114.161	0.011
477	1	121	ALA	H	H	9.237	0.010
478	1	121	ALA	HA	H	5.255	0.002
479	1	121	ALA	HB1	H	0.893	0.000
480	1	121	ALA	HB2	H	0.893	0.000
481	1	121	ALA	HB3	H	0.893	0.000
482	1	121	ALA	CA	C	49.519	0.000
483	1	121	ALA	CB	C	23.831	0.011
484	1	121	ALA	N	N	120.222	0.000
485	1	122	PHE	H	H	8.281	0.017
486	1	122	PHE	HA	H	5.770	0.021
487	1	122	PHE	HB2	H	2.913	0.012
488	1	122	PHE	HB3	H	2.913	0.012
489	1	122	PHE	HD1	H	7.257	0.019
490	1	122	PHE	HD2	H	7.257	0.019
491	1	122	PHE	CA	C	56.239	0.000
492	1	122	PHE	CB	C	41.747	0.040
493	1	122	PHE	CD1	C	132.106	0.026
494	1	122	PHE	N	N	115.661	0.015
495	1	123	VAL	H	H	8.731	0.001
496	1	123	VAL	HA	H	4.329	0.003
497	1	123	VAL	HB	H	1.417	0.004
498	1	123	VAL	HG11	H	0.135	0.002
499	1	123	VAL	HG12	H	0.135	0.002
500	1	123	VAL	HG13	H	0.135	0.002
501	1	123	VAL	HG21	H	0.333	0.003
502	1	123	VAL	HG22	H	0.333	0.003
503	1	123	VAL	HG23	H	0.333	0.003
504	1	123	VAL	CA	C	61.077	0.010
505	1	123	VAL	CB	C	33.672	0.021
506	1	123	VAL	CG1	C	21.476	0.002
507	1	123	VAL	CG2	C	21.250	0.009
508	1	123	VAL	N	N	124.759	0.020
509	1	124	GLU	H	H	8.856	0.004
510	1	124	GLU	HA	H	5.151	0.001
511	1	124	GLU	HB2	H	1.869	0.007
512	1	124	GLU	HB3	H	1.970	0.002
513	1	124	GLU	HG2	H	2.132	0.013
514	1	124	GLU	HG3	H	2.198	0.000
515	1	124	GLU	CA	C	54.555	0.000
516	1	124	GLU	CB	C	32.779	0.054
517	1	124	GLU	CG	C	36.925	0.007
518	1	124	GLU	N	N	127.449	0.162
519	1	125	PHE	H	H	8.851	0.001
520	1	125	PHE	HA	H	4.893	0.016
521	1	125	PHE	HB2	H	2.806	0.008
522	1	125	PHE	HB3	H	3.925	0.016
523	1	125	PHE	HD1	H	7.228	0.005
524	1	125	PHE	HD2	H	7.228	0.005
525	1	125	PHE	HE1	H	7.113	0.006
526	1	125	PHE	HE2	H	7.113	0.006
527	1	125	PHE	CA	C	58.784	0.000
528	1	125	PHE	CB	C	40.978	0.014
529	1	125	PHE	CD1	C	131.800	0.015
530	1	125	PHE	CE1	C	130.915	0.000
531	1	125	PHE	N	N	127.237	0.013
532	1	126	GLU	H	H	8.286	0.000
533	1	126	GLU	HA	H	4.276	0.010
534	1	126	GLU	HB2	H	2.095	0.008
535	1	126	GLU	HB3	H	2.241	0.010
536	1	126	GLU	HG2	H	2.144	0.000
537	1	126	GLU	HG3	H	2.265	0.000
538	1	126	GLU	CA	C	58.569	0.000
539	1	126	GLU	CB	C	30.466	0.018
540	1	126	GLU	CG	C	36.738	0.020
541	1	126	GLU	N	N	117.368	0.002
542	1	127	ASP	H	H	8.650	0.005
543	1	127	ASP	HA	H	5.318	0.002
544	1	127	ASP	HB2	H	2.550	0.003
545	1	127	ASP	HB3	H	3.035	0.002
546	1	127	ASP	CA	C	50.483	0.000
547	1	127	ASP	CB	C	45.454	0.006
548	1	127	ASP	N	N	120.149	0.021
549	1	128	PRO	HA	H	4.406	0.000
550	1	128	PRO	HB2	H	2.040	0.000
551	1	128	PRO	HB3	H	2.316	0.000
552	1	128	PRO	HG2	H	2.054	0.001
553	1	128	PRO	HG3	H	2.092	0.000
554	1	128	PRO	HD2	H	3.727	0.001
555	1	128	PRO	HD3	H	4.040	0.004
556	1	128	PRO	CA	C	65.181	0.000
557	1	128	PRO	CB	C	32.385	0.095
558	1	128	PRO	CG	C	27.363	0.053
559	1	128	PRO	CD	C	51.806	0.004
560	1	129	ARG	H	H	8.920	0.007
561	1	129	ARG	HA	H	4.171	0.005
562	1	129	ARG	HB2	H	1.901	0.000
563	1	129	ARG	HB3	H	1.928	0.000
564	1	129	ARG	HG2	H	1.776	0.000
565	1	129	ARG	HG3	H	1.817	0.000
566	1	129	ARG	HD2	H	3.287	0.000
567	1	129	ARG	HD3	H	3.287	0.000
568	1	129	ARG	CA	C	58.802	0.000
569	1	129	ARG	CB	C	29.624	0.001
570	1	129	ARG	CG	C	27.084	0.002
571	1	129	ARG	N	N	120.350	0.001
572	1	130	ASP	H	H	7.233	0.006
573	1	130	ASP	HA	H	4.266	0.083
574	1	130	ASP	HB2	H	2.461	0.004
575	1	130	ASP	HB3	H	2.875	0.002
576	1	130	ASP	CA	C	56.954	0.000
577	1	130	ASP	CB	C	40.153	0.011
578	1	130	ASP	N	N	121.329	0.006
579	1	131	ALA	H	H	6.753	0.007
580	1	131	ALA	HA	H	3.247	0.012
581	1	131	ALA	HB1	H	1.545	0.002
582	1	131	ALA	HB2	H	1.545	0.002
583	1	131	ALA	HB3	H	1.545	0.002
584	1	131	ALA	CA	C	54.840	0.000
585	1	131	ALA	CB	C	18.268	0.003
586	1	131	ALA	N	N	119.626	0.002
587	1	132	GLU	H	H	7.705	0.003
588	1	132	GLU	HA	H	4.054	0.004
589	1	132	GLU	HB2	H	2.271	0.050
590	1	132	GLU	HB3	H	2.347	0.006
591	1	132	GLU	HG2	H	2.479	0.004
592	1	132	GLU	HG3	H	2.615	0.005
593	1	132	GLU	CA	C	59.958	0.012
594	1	132	GLU	CB	C	29.647	0.012
595	1	132	GLU	CG	C	36.699	0.027
596	1	132	GLU	N	N	116.244	0.002
597	1	133	ASP	H	H	7.936	0.010
598	1	133	ASP	HA	H	4.412	0.017
599	1	133	ASP	HB2	H	2.698	0.088
600	1	133	ASP	HB3	H	2.886	0.112
601	1	133	ASP	CA	C	57.134	0.005
602	1	133	ASP	CB	C	40.321	0.084
603	1	133	ASP	N	N	120.671	0.002
604	1	134	ALA	H	H	7.810	0.007
605	1	134	ALA	HA	H	2.422	0.012
606	1	134	ALA	HB1	H	1.178	0.004
607	1	134	ALA	HB2	H	1.178	0.004
608	1	134	ALA	HB3	H	1.178	0.004
609	1	134	ALA	CA	C	54.441	0.000
610	1	134	ALA	CB	C	19.827	0.000
611	1	134	ALA	N	N	124.376	0.002
612	1	135	VAL	H	H	7.637	0.008
613	1	135	VAL	HA	H	3.427	0.003
614	1	135	VAL	HB	H	1.952	0.014
615	1	135	VAL	HG11	H	0.861	0.009
616	1	135	VAL	HG12	H	0.861	0.009
617	1	135	VAL	HG13	H	0.861	0.009
618	1	135	VAL	HG21	H	0.372	0.009
619	1	135	VAL	HG22	H	0.372	0.009
620	1	135	VAL	HG23	H	0.372	0.009
621	1	135	VAL	CA	C	66.537	0.004
622	1	135	VAL	CB	C	31.581	0.000
623	1	135	VAL	CG1	C	21.388	0.015
624	1	135	VAL	CG2	C	23.007	0.002
625	1	135	VAL	N	N	118.462	0.003
626	1	136	SER	H	H	7.666	0.001
627	1	136	SER	HA	H	4.299	0.003
628	1	136	SER	HB2	H	4.009	0.000
629	1	136	SER	HB3	H	4.027	0.000
630	1	136	SER	CA	C	60.907	0.000
631	1	136	SER	CB	C	63.252	0.015
632	1	136	SER	N	N	112.093	0.003
633	1	137	GLY	H	H	8.323	0.000
634	1	137	GLY	HA2	H	3.842	0.027
635	1	137	GLY	HA3	H	4.209	0.005
636	1	137	GLY	CA	C	45.678	0.004
637	1	137	GLY	N	N	106.380	0.001
638	1	138	ARG	H	H	8.015	0.005
639	1	138	ARG	HB2	H	1.682	0.008
640	1	138	ARG	HB3	H	2.058	0.033
641	1	138	ARG	HG2	H	0.927	0.010
642	1	138	ARG	HG3	H	0.927	0.010
643	1	138	ARG	HD2	H	2.812	0.040
644	1	138	ARG	HD3	H	2.812	0.040
645	1	138	ARG	CB	C	32.593	0.021
646	1	138	ARG	CG	C	26.654	0.013
647	1	138	ARG	CD	C	43.447	0.006
648	1	138	ARG	N	N	116.194	0.003
649	1	139	ASP	H	H	7.819	0.012
650	1	139	ASP	HA	H	4.588	0.004
651	1	139	ASP	HB2	H	2.740	0.002
652	1	139	ASP	HB3	H	3.420	0.010
653	1	139	ASP	CB	C	41.176	0.012
654	1	139	ASP	N	N	120.240	0.004
655	1	140	GLY	H	H	9.018	0.006
656	1	140	GLY	HA2	H	3.684	0.003
657	1	140	GLY	HA3	H	4.311	0.003
658	1	140	GLY	CA	C	45.953	0.006
659	1	140	GLY	N	N	117.537	0.001
660	1	141	TYR	H	H	8.077	0.003
661	1	141	TYR	HA	H	4.303	0.003
662	1	141	TYR	HB2	H	2.962	0.005
663	1	141	TYR	HB3	H	3.258	0.005
664	1	141	TYR	HD1	H	7.086	0.016
665	1	141	TYR	HD2	H	7.086	0.016
666	1	141	TYR	HE1	H	6.792	0.007
667	1	141	TYR	HE2	H	6.792	0.007
668	1	141	TYR	CA	C	58.510	0.015
669	1	141	TYR	CB	C	40.474	0.012
670	1	141	TYR	CD1	C	132.953	0.005
671	1	141	TYR	CE1	C	118.410	0.022
672	1	141	TYR	N	N	122.719	0.004
673	1	142	ASP	H	H	7.767	0.001
674	1	142	ASP	HA	H	4.582	0.008
675	1	142	ASP	HB2	H	2.305	0.004
676	1	142	ASP	HB3	H	2.595	0.003
677	1	142	ASP	CB	C	41.138	0.009
678	1	142	ASP	N	N	126.685	0.001
679	1	143	TYR	H	H	9.113	0.002
680	1	143	TYR	HA	H	4.597	0.000
681	1	143	TYR	HB2	H	2.673	0.003
682	1	143	TYR	HB3	H	3.603	0.005
683	1	143	TYR	HD1	H	7.087	0.006
684	1	143	TYR	HD2	H	7.087	0.006
685	1	143	TYR	HE1	H	6.794	0.004
686	1	143	TYR	HE2	H	6.794	0.004
687	1	143	TYR	CB	C	39.036	0.025
688	1	143	TYR	CD1	C	132.935	0.023
689	1	143	TYR	CE1	C	118.356	0.016
690	1	143	TYR	N	N	129.859	0.007
691	1	144	ASP	H	H	8.379	0.012
692	1	144	ASP	HA	H	4.181	0.004
693	1	144	ASP	HB2	H	2.343	0.003
694	1	144	ASP	HB3	H	3.057	0.004
695	1	144	ASP	CA	C	55.202	0.003
696	1	144	ASP	CB	C	40.194	0.015
697	1	144	ASP	N	N	124.792	0.002
698	1	145	GLY	H	H	8.324	0.000
699	1	145	GLY	HA2	H	3.616	0.003
700	1	145	GLY	HA3	H	4.191	0.001
701	1	145	GLY	CA	C	45.315	0.006
702	1	145	GLY	N	N	104.234	0.000
703	1	146	TYR	H	H	8.056	0.003
704	1	146	TYR	HA	H	4.223	0.009
705	1	146	TYR	HB2	H	3.267	0.010
706	1	146	TYR	HB3	H	3.398	0.002
707	1	146	TYR	HD1	H	7.152	0.004
708	1	146	TYR	HD2	H	7.152	0.004
709	1	146	TYR	HE1	H	6.886	0.003
710	1	146	TYR	HE2	H	6.886	0.003
711	1	146	TYR	CA	C	57.891	0.025
712	1	146	TYR	CB	C	37.881	0.040
713	1	146	TYR	CD1	C	133.952	0.007
714	1	146	TYR	CE1	C	117.857	0.021
715	1	146	TYR	N	N	123.519	0.004
716	1	147	ARG	H	H	8.238	0.003
717	1	147	ARG	HA	H	4.730	0.000
718	1	147	ARG	HB2	H	1.660	0.004
719	1	147	ARG	HB3	H	1.782	0.002
720	1	147	ARG	HG2	H	1.476	0.000
721	1	147	ARG	HG3	H	1.621	0.043
722	1	147	ARG	HD2	H	3.235	0.048
723	1	147	ARG	HD3	H	3.235	0.048
724	1	147	ARG	CB	C	29.236	0.007
725	1	147	ARG	CG	C	27.474	0.014
726	1	147	ARG	CD	C	43.380	0.000
727	1	147	ARG	N	N	122.896	0.003
728	1	148	LEU	H	H	9.435	0.002
729	1	148	LEU	HA	H	4.588	0.000
730	1	148	LEU	HB2	H	1.403	0.006
731	1	148	LEU	HB3	H	1.403	0.006
732	1	148	LEU	HG	H	1.667	0.003
733	1	148	LEU	HD11	H	0.964	0.033
734	1	148	LEU	HD12	H	0.964	0.033
735	1	148	LEU	HD13	H	0.964	0.033
736	1	148	LEU	HD21	H	0.996	0.004
737	1	148	LEU	HD22	H	0.996	0.004
738	1	148	LEU	HD23	H	0.996	0.004
739	1	148	LEU	CB	C	42.519	0.000
740	1	148	LEU	CG	C	26.748	0.000
741	1	148	LEU	CD1	C	23.232	0.000
742	1	148	LEU	CD2	C	25.871	0.000
743	1	148	LEU	N	N	129.275	0.003
744	1	149	ARG	H	H	8.040	0.001
745	1	149	ARG	HA	H	5.074	0.003
746	1	149	ARG	HB2	H	1.759	0.000
747	1	149	ARG	HB3	H	1.844	0.000
748	1	149	ARG	HG2	H	1.729	0.022
749	1	149	ARG	HG3	H	1.834	0.066
750	1	149	ARG	HD2	H	3.398	0.004
751	1	149	ARG	HD3	H	3.398	0.004
752	1	149	ARG	CA	C	54.169	0.035
753	1	149	ARG	CB	C	32.066	0.029
754	1	149	ARG	CG	C	27.343	0.002
755	1	149	ARG	CD	C	43.621	0.000
756	1	149	ARG	N	N	123.768	0.005
757	1	150	VAL	H	H	9.481	0.007
758	1	150	VAL	HA	H	5.498	0.003
759	1	150	VAL	HB	H	2.004	0.005
760	1	150	VAL	HG11	H	1.065	0.016
761	1	150	VAL	HG12	H	1.065	0.016
762	1	150	VAL	HG13	H	1.065	0.016
763	1	150	VAL	HG21	H	1.041	0.016
764	1	150	VAL	HG22	H	1.041	0.016
765	1	150	VAL	HG23	H	1.041	0.016
766	1	150	VAL	CA	C	60.858	0.000
767	1	150	VAL	CB	C	33.825	0.000
768	1	150	VAL	CG1	C	22.870	0.005
769	1	150	VAL	CG2	C	24.751	0.004
770	1	150	VAL	N	N	127.312	0.002
771	1	151	GLU	H	H	9.009	0.001
772	1	151	GLU	HA	H	4.758	0.007
773	1	151	GLU	HB2	H	1.939	0.017
774	1	151	GLU	HB3	H	2.289	0.013
775	1	151	GLU	HG2	H	2.062	0.005
776	1	151	GLU	HG3	H	2.285	0.016
777	1	151	GLU	CB	C	34.350	0.036
778	1	151	GLU	CG	C	35.230	0.030
779	1	151	GLU	N	N	121.631	0.009
780	1	152	PHE	H	H	8.740	0.003
781	1	152	PHE	HA	H	5.078	0.006
782	1	152	PHE	HB2	H	2.882	0.004
783	1	152	PHE	HB3	H	3.323	0.005
784	1	152	PHE	HD1	H	7.524	0.008
785	1	152	PHE	HD2	H	7.524	0.008
786	1	152	PHE	HE1	H	7.293	0.006
787	1	152	PHE	HE2	H	7.293	0.006
788	1	152	PHE	HZ	H	7.062	0.004
789	1	152	PHE	CA	C	57.783	0.035
790	1	152	PHE	CD1	C	131.946	0.048
791	1	152	PHE	CE1	C	131.791	0.000
792	1	152	PHE	CZ	C	129.472	0.000
793	1	152	PHE	N	N	120.031	0.004
794	1	153	PRO	HB3	H	2.330	0.000
795	1	153	PRO	HG2	H	2.013	0.000
796	1	153	PRO	HG3	H	2.013	0.000
797	1	153	PRO	HD2	H	4.205	0.002
798	1	153	PRO	HD3	H	4.386	0.001
799	1	153	PRO	CG	C	28.172	0.000
800	1	153	PRO	CD	C	51.336	0.011
801	2	1	A	H1'	H	5.993	0.003
802	2	1	A	H2	H	8.093	0.001
803	2	1	A	H2'	H	4.810	0.028
804	2	1	A	H3'	H	4.763	0.002
805	2	1	A	H4'	H	4.425	0.003
806	2	1	A	H5'	H	4.378	0.001
807	2	1	A	H8	H	8.301	0.004
808	2	2	A	H1'	H	6.022	0.007
809	2	2	A	H2	H	8.161	0.003
810	2	2	A	H2'	H	4.831	0.001
811	2	2	A	H3'	H	4.805	0.013
812	2	2	A	H4'	H	4.528	0.063
813	2	2	A	H5'	H	4.261	0.002
814	2	2	A	H8	H	8.379	0.004
815	2	3	C	H1'	H	6.013	0.004
816	2	3	C	H2'	H	4.241	0.000
817	2	3	C	H3'	H	4.298	0.001
818	2	3	C	H4'	H	4.654	0.002
819	2	3	C	H5	H	5.341	0.003
820	2	3	C	H6	H	7.403	0.005
821	2	4	A	H1'	H	6.001	0.002
822	2	4	A	H2	H	8.028	0.001
823	2	4	A	H2'	H	4.828	0.003
824	2	4	A	H3'	H	4.785	0.001
825	2	4	A	H4'	H	4.630	0.040
826	2	4	A	H5'	H	4.297	0.001
827	2	4	A	H5''	H	4.240	0.000
828	2	4	A	H8	H	8.405	0.001
829	2	5	A	H1'	H	5.970	0.003
830	2	5	A	H2	H	8.066	0.036
831	2	5	A	H2'	H	4.818	0.003
832	2	5	A	H3'	H	4.696	0.001
833	2	5	A	H4'	H	4.559	0.002
834	2	5	A	H5'	H	4.382	0.002
835	2	5	A	H5''	H	4.267	0.002
836	2	5	A	H8	H	8.291	0.004
837	2	6	A	H1'	H	6.051	0.003
838	2	6	A	H2	H	8.182	0.003
839	2	6	A	H2'	H	4.610	0.003
840	2	6	A	H3'	H	4.530	0.003
841	2	6	A	H4'	H	4.409	0.002
842	2	6	A	H5'	H	4.377	0.001
843	2	6	A	H5''	H	4.268	0.000
844	2	6	A	H8	H	8.326	0.001

Protein Blocks Logo

Calculated from 20 models in PDB: 6HPJ, Strand ID: B Detail

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Release date

2019-07-21

Citation

Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing
Clery, A., Krepl, M., Nguyen, C., Moursy, A., Jorjani, H., Katsantoni, M., Okoniewski, M., Mittal, N., Zavolan, M., Sponer, J., Allain, F.H.
Nat. Commun. (2021), 12, 428-428, PubMed 33462199 , DOI 10.1038/s41467-020-20481-w , Abstract