BMRB: 34331

Human telomeric G-quadruplex with 8-oxo-G substitution in the central G-quartet

Authors

Bielskute, S., Plavec, J., Podbevsek, P.

Assembly

hTel-oxoG10

Entity

1. hTel-oxoG10 (polymer, Thiol state: not present), 24 monomers, 7670.853 Da Detail

TTGGGTTAGX GTTAGGGTTA GGGA

Formula weight

7670.853 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 95.8 %, Completeness: 63.3 %, Completeness (bb): 55.3 % Detail

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Polymer type: polydeoxyribonucleotide

	Total	1H
All	63.3 % (136 of 215)	63.3 % (136 of 215)
Suger, PO4	55.3 % (89 of 161)	55.3 % (89 of 161)
Nucleobase	87.0 % (47 of 54)	87.0 % (47 of 54)
Aromatic	84.8 % (39 of 46)	84.8 % (39 of 46)
Methyl	100.0 % (8 of 8)	100.0 % (8 of 8)

1. entity 1

TTGGGTTAGX GTTAGGGTTA GGGA

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Sample

Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 278 K, pH 7, Details 1 mM DNA, 90% H2O/10% D2O

#	Name	Isotope labeling	Type	Concentration
1	DNA	natural abundance		1 (±0.2) mM
2	potassium phosphate buffer	natural abundance		20 mM
3	KCl	natural abundance		70 mM

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Release date

2018-11-25

Citation

Impact of Oxidative Lesions on the Human Telomeric G-quadruplex
Bielskute, S., Plavec, J., Podbevsek, P.
J. Am. Chem. Soc. (2019), 141, 2594-2603, PubMed 30657306 , DOI 10.1021/jacs.8b12748 , Abstract

Entries sharing articles BMRB: 1 entries Detail

Related entities 1. hTel-oxoG10, : 1 entities Detail

Experiments performed 2 experiments Detail