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BMRB: 34402


34402
6RRO
Solution NMR structure of the peptide 536_2 from medicinal leech Hirudo medicinalis in dodecylphosphocholine micelles
Authors
Nadezhdin, K.D., Grafskaia, E.N., Arseniev, A.S., Lazarev, V.N.
Assembly
peptide 536 2
Entity
1. peptide 536 2 (polymer, Thiol state: not present), 11 monomers, 1319.678 Da Detail

GFIVKRFKIL V


Formula weight
1319.678 Da
Source organism
Hirudo medicinalis
Exptl. method
solution NMR
Refine. method
torsion angle dynamics
Data set
assigned_chemical_shifts, spectral_peak_list
Chem. Shift Complete
Sequence coverage: 100.0 %, Completeness: 81.9 %, Completeness (bb): 74.5 % Detail
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Polymer type: polypeptide(L)

Total1H13C
All81.9 % (118 of 144)95.1 % (77 of 81)65.1 % (41 of 63)
Backbone74.5 % (41 of 55)91.3 % (21 of 23)62.5 % (20 of 32)
Sidechain86.9 % (86 of 99)96.6 % (56 of 58)73.2 % (30 of 41)
Aromatic40.0 % (8 of 20)80.0 % (8 of 10) 0.0 % (0 of 10)
Methyl100.0 % (20 of 20)100.0 % (10 of 10)100.0 % (10 of 10)

1. entity 1

GFIVKRFKIL V

Show sample condition
Sample

Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 303 K, pH 4 (±0.1), Details 1 mM peptide 536_2, 100 mM dodecylphosphocholine, 90% H2O/10% D2O


#NameIsotope labelingTypeConcentration
1peptide 536_2natural abundance1 (±0.2) mM
2dodecylphosphocholinenatural abundance100 (±5.0) mM

Protein Blocks Logo
Calculated from 20 models in PDB: 6RRO, Strand ID: A Detail

Release date
2019-10-10
Citation
Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens
Grafskaia, E.N., Nadezhdin, K.D., Talyzina, I.A., Polina, N.F., Podgorny, O.V., Pavlova, E.R., Bashkirov, P.V., Kharlampieva, D.D., Bobrovsky, P.A., Latsis, I.A., Manuvera, V.A., Babenko, V.V., Trukhan, V.M., Arseniev, A.S., Klinov, D.V., Lazarev, V.N.
Eur. J. Med. Chem. (2019), 180, 143-153, PubMed 31302447 , DOI 10.1016/j.ejmech.2019.06.080 ,
Entries sharing articles BMRB: 2 entries Detail
  BMRB: 34401 released on 2019-10-10
    Title Solution NMR structure of the peptide 3967 from medicinal leech Hirudo medicinalis in dodecylphosphocholine micelles
  BMRB: 34406 released on 2019-10-10
    Title Solution NMR structure of the peptide 12530 from medicinal leech Hirudo medicinalis in dodecylphosphocholine micelles
Related entities 1. peptide 536 2, : 1 entities Detail
More details for 1 related entities
Experiments performed 3 experiments Detail
Chemical shift validation 3 contents Detail
Keywords ANTIMICROBIAL PROTEIN, Hirudo medicinalis, antimicrobial peptides, dooecylphosphocholine micelles, genome, medicinal leech, prediction algorithm