BMRB: 34467

Pre-folded structures govern folding pathways of human telomeric G-quadruplexes

Authors

Wang, B., Frelih, T., Plavec, J., Sket, P.

Assembly

human telomeric G-quadruplexes

Entity

1. human telomeric G-quadruplexes (polymer, Thiol state: not present), 23 monomers, 7350.660 Da Detail

TAGGGTTAGG GTTAGGGTTA GGG

Formula weight

7350.66 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 69.6 %, Completeness: 14.0 %, Completeness (bb): 0.0 % Detail

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Polymer type: polydeoxyribonucleotide

	Total	1H
All	14.0 % (30 of 214)	14.0 % (30 of 214)
Suger, PO4	0.0 % (0 of 161)	0.0 % (0 of 161)
Nucleobase	56.6 % (30 of 53)	56.6 % (30 of 53)
Aromatic	50.0 % (23 of 46)	50.0 % (23 of 46)
Methyl	100.0 % (7 of 7)	100.0 % (7 of 7)

1. entity 1

TAGGGTTAGG GTTAGGGTTA GGG

Show sample condition

Sample #1

Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 278 K, pH 5, Details 1 mM 8% 13C, 8% 15N GCN, 90% H2O/10% D2O

#	Name	Isotope labeling	Type	Concentration
1	GCN	[8% 13C; 8% 15N]		1 mM

Sample #2

Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 278 K, pH 5, Details 1 mM GCN, 90% H2O/10% D2O

#	Name	Isotope labeling	Type	Concentration
2	GCN	natural abundance		1 mM

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Release date

2019-12-22

Citation

Pre-folded structures govern folding pathways of human telomeric G-quadruplexes
Baifan, W., Tjasa, F., Janez, P., Primoz, S.
Nucleic Acids Res. (2020), 48, 2189-2197, PubMed 31950178 , DOI 10.1093/nar/gkz1235 , Abstract

Related entities 1. human telomeric G-quadruplexes, : 2 entities Detail

Experiments performed 4 experiments Detail

Chemical shift validation 3 contents Detail