BMRB: 34726

RNA binding induces an allosteric switch in Cyp33 to repress MLL1 mediated transcription regulation

Authors

Blatter, M., Allain, F., Meylan, C.

Assembly

Isoform 3 of Peptidyl-prolyl cis-trans isomerase E/RNA Complex

Entity

1. Isoform 3 of Peptidyl-prolyl cis-trans isomerase E/RNA Complex, entity 1 (polymer, Thiol state: not present), 93 monomers, 10336.61 Da Detail

AGHMATTKRV LYVGGLAEEV DDKVLHAAFI PFGDITDIQI PLDYETEKHR GFAFVEFELA EDAAAAIDNM NESELFGRTI RVNLAKPMRI KEG

2. Isoform 3 of Peptidyl-prolyl cis-trans isomerase E/RNA Complex, entity 2 (polymer), 8 monomers, 2590.517 Da Detail

UAAUGUCG

Total weight

12927.127 Da

Max. entity weight

10336.61 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chemcal Shifts

¹H: 722, ¹³C: 368, ¹⁵N: 91 assignments Detail

Download

• NMR-STAR v3.1 (partial)
• BMRB/XML (partial)
• CSV
• TSV

ID	Entity ID	Seq ID	Comp ID	Atom ID	Atom type	Val	Val err	Ambig. code
1	1	1	ALA	HA	H	4.122	0.000
2	1	1	ALA	HB1	H	1.549	0.000
3	1	1	ALA	HB2	H	1.549	0.000
4	1	1	ALA	HB3	H	1.549	0.000
5	1	1	ALA	CA	C	52.041	0.000
6	1	1	ALA	CB	C	19.647	0.000
7	1	2	GLY	HA2	H	4.009	0.000
8	1	2	GLY	HA3	H	4.009	0.000
9	1	2	GLY	CA	C	45.220	0.000
10	1	3	HIS	HA	H	4.689	0.000
11	1	3	HIS	HB2	H	3.163	0.000
12	1	3	HIS	HB3	H	3.118	0.000
13	1	3	HIS	HD2	H	7.077	0.000
14	1	3	HIS	HE1	H	7.982	0.000
15	1	3	HIS	CA	C	56.404	0.000
16	1	3	HIS	CB	C	30.785	0.002
17	1	3	HIS	CD2	C	119.932	0.000
18	1	3	HIS	CE1	C	138.208	0.000
19	1	4	MET	H	H	8.385	0.000
20	1	4	MET	HA	H	4.510	0.000
21	1	4	MET	HB2	H	2.097	0.000
22	1	4	MET	HB3	H	2.020	0.000
23	1	4	MET	HG2	H	2.575	0.000
24	1	4	MET	HG3	H	2.493	0.000
25	1	4	MET	HE1	H	2.105	0.000
26	1	4	MET	HE2	H	2.105	0.000
27	1	4	MET	HE3	H	2.105	0.000
28	1	4	MET	CA	C	55.535	0.000
29	1	4	MET	CB	C	32.999	0.007
30	1	4	MET	CG	C	32.016	0.004
31	1	4	MET	CE	C	17.029	0.000
32	1	4	MET	N	N	121.711	0.000
33	1	5	ALA	H	H	8.451	0.000
34	1	5	ALA	HA	H	4.450	0.000
35	1	5	ALA	HB1	H	1.480	0.000
36	1	5	ALA	HB2	H	1.480	0.000
37	1	5	ALA	HB3	H	1.480	0.000
38	1	5	ALA	CA	C	52.766	0.000
39	1	5	ALA	CB	C	19.346	0.000
40	1	5	ALA	N	N	125.342	0.000
41	1	6	THR	H	H	8.183	0.000
42	1	6	THR	HA	H	4.463	0.000
43	1	6	THR	HB	H	4.376	0.000
44	1	6	THR	HG21	H	1.294	0.000
45	1	6	THR	HG22	H	1.294	0.000
46	1	6	THR	HG23	H	1.294	0.000
47	1	6	THR	CA	C	61.987	0.000
48	1	6	THR	CB	C	69.555	0.000
49	1	6	THR	CG2	C	21.716	0.000
50	1	6	THR	N	N	112.619	0.000
51	1	7	THR	H	H	8.023	0.000
52	1	7	THR	HA	H	4.483	0.000
53	1	7	THR	HB	H	4.431	0.000
54	1	7	THR	HG21	H	1.340	0.000
55	1	7	THR	HG22	H	1.340	0.000
56	1	7	THR	HG23	H	1.340	0.000
57	1	7	THR	CA	C	61.953	0.000
58	1	7	THR	CB	C	70.141	0.000
59	1	7	THR	CG2	C	21.759	0.000
60	1	7	THR	N	N	114.546	0.000
61	1	8	LYS	H	H	8.282	0.000
62	1	8	LYS	HA	H	4.486	0.000
63	1	8	LYS	HB2	H	2.098	0.000
64	1	8	LYS	HB3	H	1.925	0.000
65	1	8	LYS	HG2	H	1.558	0.000
66	1	8	LYS	HG3	H	1.468	0.000
67	1	8	LYS	HD2	H	1.773	0.000
68	1	8	LYS	HD3	H	1.715	0.000
69	1	8	LYS	HE2	H	3.030	0.000
70	1	8	LYS	HE3	H	3.030	0.000
71	1	8	LYS	CA	C	57.078	0.000
72	1	8	LYS	CB	C	31.822	0.011
73	1	8	LYS	CG	C	25.366	0.004
74	1	8	LYS	CD	C	29.345	0.002
75	1	8	LYS	CE	C	42.209	0.000
76	1	8	LYS	N	N	119.545	0.000
77	1	9	ARG	H	H	7.992	0.000
78	1	9	ARG	HA	H	4.421	0.000
79	1	9	ARG	HB2	H	2.317	0.000
80	1	9	ARG	HB3	H	1.778	0.000
81	1	9	ARG	HG2	H	1.722	0.000
82	1	9	ARG	HG3	H	1.382	0.000
83	1	9	ARG	HD2	H	3.425	0.000
84	1	9	ARG	HD3	H	3.204	0.000
85	1	9	ARG	CA	C	56.338	0.000
86	1	9	ARG	CB	C	32.438	0.002
87	1	9	ARG	CG	C	27.591	0.001
88	1	9	ARG	CD	C	43.913	0.001
89	1	9	ARG	N	N	115.401	0.000
90	1	10	VAL	H	H	7.757	0.000
91	1	10	VAL	HA	H	4.787	0.000
92	1	10	VAL	HB	H	2.104	0.000
93	1	10	VAL	HG11	H	0.998	0.000
94	1	10	VAL	HG12	H	0.998	0.000
95	1	10	VAL	HG13	H	0.998	0.000
96	1	10	VAL	HG21	H	0.956	0.000
97	1	10	VAL	HG22	H	0.956	0.000
98	1	10	VAL	HG23	H	0.956	0.000
99	1	10	VAL	CA	C	61.629	0.000
100	1	10	VAL	CB	C	32.922	0.000
101	1	10	VAL	CG1	C	21.660	0.000
102	1	10	VAL	CG2	C	22.124	0.000
103	1	10	VAL	N	N	118.008	0.000
104	1	11	LEU	H	H	9.701	0.000
105	1	11	LEU	HA	H	5.041	0.000
106	1	11	LEU	HB2	H	1.734	0.000
107	1	11	LEU	HB3	H	1.357	0.000
108	1	11	LEU	HG	H	1.874	0.000
109	1	11	LEU	HD11	H	0.780	0.000
110	1	11	LEU	HD12	H	0.780	0.000
111	1	11	LEU	HD13	H	0.780	0.000
112	1	11	LEU	HD21	H	0.904	0.000
113	1	11	LEU	HD22	H	0.904	0.000
114	1	11	LEU	HD23	H	0.904	0.000
115	1	11	LEU	CA	C	53.511	0.000
116	1	11	LEU	CB	C	43.247	0.003
117	1	11	LEU	CG	C	27.023	0.000
118	1	11	LEU	CD1	C	25.008	0.000
119	1	11	LEU	CD2	C	26.569	0.000
120	1	11	LEU	N	N	127.684	0.000
121	1	12	TYR	H	H	9.192	0.000
122	1	12	TYR	HA	H	4.622	0.000
123	1	12	TYR	HB2	H	2.725	0.000
124	1	12	TYR	HB3	H	2.655	0.000
125	1	12	TYR	HD1	H	6.539	0.000
126	1	12	TYR	HD2	H	6.539	0.000
127	1	12	TYR	HE1	H	6.106	0.000
128	1	12	TYR	HE2	H	6.106	0.000
129	1	12	TYR	CA	C	57.397	0.000
130	1	12	TYR	CB	C	40.179	0.004
131	1	12	TYR	CD1	C	132.976	0.000
132	1	12	TYR	CE1	C	118.054	0.000
133	1	12	TYR	N	N	123.984	0.000
134	1	13	VAL	H	H	8.076	0.000
135	1	13	VAL	HA	H	4.761	0.000
136	1	13	VAL	HB	H	1.590	0.000
137	1	13	VAL	HG11	H	0.823	0.000
138	1	13	VAL	HG12	H	0.823	0.000
139	1	13	VAL	HG13	H	0.823	0.000
140	1	13	VAL	HG21	H	0.561	0.000
141	1	13	VAL	HG22	H	0.561	0.000
142	1	13	VAL	HG23	H	0.561	0.000
143	1	13	VAL	CA	C	59.831	0.000
144	1	13	VAL	CB	C	33.171	0.000
145	1	13	VAL	CG1	C	22.111	0.000
146	1	13	VAL	CG2	C	21.150	0.000
147	1	13	VAL	N	N	127.333	0.000
148	1	14	GLY	H	H	9.184	0.000
149	1	14	GLY	HA2	H	4.797	0.000
150	1	14	GLY	HA3	H	3.634	0.000
151	1	14	GLY	CA	C	43.270	0.090
152	1	14	GLY	N	N	112.428	0.000
153	1	15	GLY	H	H	8.121	0.000
154	1	15	GLY	HA2	H	4.445	0.000
155	1	15	GLY	HA3	H	3.826	0.000
156	1	15	GLY	CA	C	45.959	0.010
157	1	15	GLY	N	N	107.661	0.000
158	1	16	LEU	H	H	7.926	0.000
159	1	16	LEU	HA	H	4.107	0.000
160	1	16	LEU	HB2	H	1.206	0.000
161	1	16	LEU	HB3	H	0.936	0.000
162	1	16	LEU	HG	H	1.346	0.000
163	1	16	LEU	HD11	H	0.572	0.000
164	1	16	LEU	HD12	H	0.572	0.000
165	1	16	LEU	HD13	H	0.572	0.000
166	1	16	LEU	HD21	H	0.262	0.000
167	1	16	LEU	HD22	H	0.262	0.000
168	1	16	LEU	HD23	H	0.262	0.000
169	1	16	LEU	CA	C	53.982	0.000
170	1	16	LEU	CB	C	42.270	0.001
171	1	16	LEU	CG	C	26.302	0.000
172	1	16	LEU	CD1	C	22.568	0.000
173	1	16	LEU	CD2	C	25.553	0.000
174	1	16	LEU	N	N	116.392	0.000
175	1	17	ALA	H	H	8.534	0.000
176	1	17	ALA	HA	H	4.352	0.000
177	1	17	ALA	HB1	H	1.723	0.000
178	1	17	ALA	HB2	H	1.723	0.000
179	1	17	ALA	HB3	H	1.723	0.000
180	1	17	ALA	CA	C	51.486	0.000
181	1	17	ALA	CB	C	19.782	0.000
182	1	17	ALA	N	N	126.572	0.000
183	1	18	GLU	H	H	9.062	0.000
184	1	18	GLU	HA	H	3.678	0.000
185	1	18	GLU	HB2	H	2.039	0.000
186	1	18	GLU	HB3	H	1.939	0.000
187	1	18	GLU	HG2	H	2.286	0.000
188	1	18	GLU	HG3	H	2.286	0.000
189	1	18	GLU	CA	C	60.110	0.000
190	1	18	GLU	CB	C	29.641	0.004
191	1	18	GLU	CG	C	36.691	0.000
192	1	18	GLU	N	N	122.718	0.000
193	1	19	GLU	H	H	8.987	0.000
194	1	19	GLU	HA	H	4.053	0.000
195	1	19	GLU	HB2	H	1.847	0.000
196	1	19	GLU	HB3	H	1.588	0.000
197	1	19	GLU	HG2	H	2.306	0.000
198	1	19	GLU	HG3	H	2.169	0.000
199	1	19	GLU	CA	C	58.097	0.000
200	1	19	GLU	CB	C	29.141	0.008
201	1	19	GLU	CG	C	37.024	0.006
202	1	19	GLU	N	N	114.323	0.000
203	1	20	VAL	H	H	7.533	0.000
204	1	20	VAL	HA	H	3.185	0.000
205	1	20	VAL	HB	H	2.120	0.000
206	1	20	VAL	HG11	H	0.796	0.000
207	1	20	VAL	HG12	H	0.796	0.000
208	1	20	VAL	HG13	H	0.796	0.000
209	1	20	VAL	HG21	H	0.871	0.000
210	1	20	VAL	HG22	H	0.871	0.000
211	1	20	VAL	HG23	H	0.871	0.000
212	1	20	VAL	CA	C	65.294	0.000
213	1	20	VAL	CB	C	30.728	0.000
214	1	20	VAL	CG1	C	22.338	0.000
215	1	20	VAL	CG2	C	23.278	0.000
216	1	20	VAL	N	N	119.250	0.000
217	1	21	ASP	H	H	6.790	0.000
218	1	21	ASP	HA	H	4.742	0.000
219	1	21	ASP	HB2	H	3.243	0.000
220	1	21	ASP	HB3	H	2.810	0.000
221	1	21	ASP	CA	C	51.533	0.000
222	1	21	ASP	CB	C	42.803	0.007
223	1	21	ASP	N	N	125.164	0.000
224	1	22	ASP	H	H	8.810	0.000
225	1	22	ASP	HA	H	3.988	0.000
226	1	22	ASP	HB2	H	2.662	0.000
227	1	22	ASP	HB3	H	2.662	0.000
228	1	22	ASP	CA	C	57.567	0.000
229	1	22	ASP	CB	C	39.270	0.000
230	1	22	ASP	N	N	115.967	0.000
231	1	23	LYS	H	H	7.685	0.000
232	1	23	LYS	HA	H	4.155	0.000
233	1	23	LYS	HB2	H	2.195	0.000
234	1	23	LYS	HB3	H	1.954	0.000
235	1	23	LYS	HG2	H	1.603	0.000
236	1	23	LYS	HG3	H	1.511	0.000
237	1	23	LYS	HD2	H	1.753	0.000
238	1	23	LYS	HD3	H	1.753	0.000
239	1	23	LYS	HE2	H	3.093	0.000
240	1	23	LYS	HE3	H	3.093	0.000
241	1	23	LYS	CA	C	59.385	0.000
242	1	23	LYS	CB	C	31.542	0.010
243	1	23	LYS	CG	C	25.121	0.009
244	1	23	LYS	CD	C	28.682	0.000
245	1	23	LYS	CE	C	42.063	0.000
246	1	23	LYS	N	N	121.492	0.000
247	1	24	VAL	H	H	8.323	0.000
248	1	24	VAL	HA	H	3.874	0.000
249	1	24	VAL	HB	H	2.251	0.000
250	1	24	VAL	HG11	H	1.034	0.000
251	1	24	VAL	HG12	H	1.034	0.000
252	1	24	VAL	HG13	H	1.034	0.000
253	1	24	VAL	HG21	H	1.326	0.000
254	1	24	VAL	HG22	H	1.326	0.000
255	1	24	VAL	HG23	H	1.326	0.000
256	1	24	VAL	CA	C	65.971	0.000
257	1	24	VAL	CB	C	32.489	0.000
258	1	24	VAL	CG1	C	22.457	0.000
259	1	24	VAL	CG2	C	22.492	0.000
260	1	24	VAL	N	N	122.336	0.000
261	1	25	LEU	H	H	8.061	0.000
262	1	25	LEU	HA	H	4.131	0.000
263	1	25	LEU	HB2	H	1.803	0.000
264	1	25	LEU	HB3	H	1.316	0.000
265	1	25	LEU	HG	H	1.589	0.000
266	1	25	LEU	HD11	H	0.660	0.000
267	1	25	LEU	HD12	H	0.660	0.000
268	1	25	LEU	HD13	H	0.660	0.000
269	1	25	LEU	HD21	H	0.507	0.000
270	1	25	LEU	HD22	H	0.507	0.000
271	1	25	LEU	HD23	H	0.507	0.000
272	1	25	LEU	CA	C	58.003	0.000
273	1	25	LEU	CB	C	42.614	0.002
274	1	25	LEU	CG	C	26.481	0.000
275	1	25	LEU	CD1	C	23.788	0.000
276	1	25	LEU	CD2	C	26.080	0.000
277	1	25	LEU	N	N	118.626	0.000
278	1	26	HIS	H	H	8.651	0.000
279	1	26	HIS	HA	H	3.891	0.000
280	1	26	HIS	HB2	H	3.306	0.000
281	1	26	HIS	HB3	H	3.224	0.000
282	1	26	HIS	HD2	H	6.961	0.000
283	1	26	HIS	HE1	H	7.965	0.000
284	1	26	HIS	CA	C	61.867	0.000
285	1	26	HIS	CB	C	30.415	0.003
286	1	26	HIS	CD2	C	118.847	0.000
287	1	26	HIS	CE1	C	138.019	0.000
288	1	26	HIS	N	N	119.128	0.000
289	1	27	ALA	H	H	7.851	0.000
290	1	27	ALA	HA	H	4.198	0.000
291	1	27	ALA	HB1	H	1.635	0.000
292	1	27	ALA	HB2	H	1.635	0.000
293	1	27	ALA	HB3	H	1.635	0.000
294	1	27	ALA	CA	C	54.871	0.000
295	1	27	ALA	CB	C	18.220	0.000
296	1	27	ALA	N	N	117.935	0.000
297	1	28	ALA	H	H	7.923	0.000
298	1	28	ALA	HA	H	4.221	0.000
299	1	28	ALA	HB1	H	1.412	0.000
300	1	28	ALA	HB2	H	1.412	0.000
301	1	28	ALA	HB3	H	1.412	0.000
302	1	28	ALA	CA	C	53.644	0.000
303	1	28	ALA	CB	C	18.729	0.000
304	1	28	ALA	N	N	117.369	0.000
305	1	29	PHE	H	H	7.874	0.000
306	1	29	PHE	HA	H	5.047	0.000
307	1	29	PHE	HB2	H	3.482	0.000
308	1	29	PHE	HB3	H	2.928	0.000
309	1	29	PHE	HD1	H	7.747	0.000
310	1	29	PHE	HD2	H	7.747	0.000
311	1	29	PHE	HE1	H	6.965	0.000
312	1	29	PHE	HE2	H	6.965	0.000
313	1	29	PHE	HZ	H	6.968	0.000
314	1	29	PHE	CA	C	60.374	0.000
315	1	29	PHE	CB	C	40.695	0.001
316	1	29	PHE	CD1	C	131.771	0.000
317	1	29	PHE	CE1	C	130.291	0.000
318	1	29	PHE	CZ	C	128.804	0.000
319	1	29	PHE	N	N	112.217	0.000
320	1	30	ILE	H	H	8.641	0.000
321	1	30	ILE	HA	H	4.763	0.000
322	1	30	ILE	HB	H	1.670	0.000
323	1	30	ILE	HG12	H	1.490	0.000
324	1	30	ILE	HG13	H	1.396	0.000
325	1	30	ILE	HG21	H	1.009	0.000
326	1	30	ILE	HG22	H	1.009	0.000
327	1	30	ILE	HG23	H	1.009	0.000
328	1	30	ILE	HD11	H	1.143	0.000
329	1	30	ILE	HD12	H	1.143	0.000
330	1	30	ILE	HD13	H	1.143	0.000
331	1	30	ILE	CA	C	60.903	0.000
332	1	30	ILE	CB	C	38.468	0.000
333	1	30	ILE	CG1	C	29.673	0.008
334	1	30	ILE	CG2	C	19.460	0.000
335	1	30	ILE	CD1	C	14.586	0.000
336	1	30	ILE	N	N	123.357	0.000
337	1	31	PRO	HA	H	4.187	0.000
338	1	31	PRO	HB2	H	2.006	0.000
339	1	31	PRO	HB3	H	0.483	0.000
340	1	31	PRO	HG2	H	1.707	0.000
341	1	31	PRO	HG3	H	1.707	0.000
342	1	31	PRO	HD2	H	3.840	0.000
343	1	31	PRO	HD3	H	2.996	0.000
344	1	31	PRO	CA	C	65.400	0.000
345	1	31	PRO	CB	C	30.821	0.003
346	1	31	PRO	CG	C	28.359	0.000
347	1	31	PRO	CD	C	52.203	0.000
348	1	32	PHE	H	H	7.614	0.000
349	1	32	PHE	HA	H	4.254	0.000
350	1	32	PHE	HB2	H	3.376	0.000
351	1	32	PHE	HB3	H	3.072	0.000
352	1	32	PHE	HD1	H	7.614	0.000
353	1	32	PHE	HD2	H	7.614	0.000
354	1	32	PHE	HE1	H	7.405	0.000
355	1	32	PHE	HE2	H	7.405	0.000
356	1	32	PHE	HZ	H	7.245	0.000
357	1	32	PHE	CA	C	59.625	0.000
358	1	32	PHE	CB	C	38.873	0.003
359	1	32	PHE	CD1	C	131.530	0.000
360	1	32	PHE	CE1	C	131.698	0.000
361	1	32	PHE	CZ	C	131.498	0.000
362	1	32	PHE	N	N	112.212	0.000
363	1	33	GLY	H	H	7.635	0.000
364	1	33	GLY	HA2	H	5.031	0.000
365	1	33	GLY	HA3	H	3.828	0.000
366	1	33	GLY	CA	C	44.439	0.017
367	1	33	GLY	N	N	106.057	0.000
368	1	34	ASP	H	H	8.022	0.000
369	1	34	ASP	HA	H	4.546	0.000
370	1	34	ASP	HB2	H	2.674	0.000
371	1	34	ASP	HB3	H	2.674	0.000
372	1	34	ASP	CA	C	56.493	0.000
373	1	34	ASP	CB	C	41.210	0.000
374	1	34	ASP	N	N	114.489	0.000
375	1	35	ILE	H	H	7.512	0.000
376	1	35	ILE	HA	H	4.194	0.000
377	1	35	ILE	HB	H	1.440	0.000
378	1	35	ILE	HG12	H	1.711	0.000
379	1	35	ILE	HG13	H	-0.147	0.000
380	1	35	ILE	HG21	H	0.696	0.000
381	1	35	ILE	HG22	H	0.696	0.000
382	1	35	ILE	HG23	H	0.696	0.000
383	1	35	ILE	HD11	H	0.431	0.000
384	1	35	ILE	HD12	H	0.431	0.000
385	1	35	ILE	HD13	H	0.431	0.000
386	1	35	ILE	CA	C	60.679	0.000
387	1	35	ILE	CB	C	41.668	0.000
388	1	35	ILE	CG1	C	27.596	0.008
389	1	35	ILE	CG2	C	17.251	0.000
390	1	35	ILE	CD1	C	14.491	0.000
391	1	35	ILE	N	N	124.509	0.000
392	1	36	THR	H	H	9.080	0.000
393	1	36	THR	HA	H	4.294	0.000
394	1	36	THR	HB	H	4.009	0.000
395	1	36	THR	HG21	H	1.113	0.000
396	1	36	THR	HG22	H	1.113	0.000
397	1	36	THR	HG23	H	1.113	0.000
398	1	36	THR	CA	C	63.228	0.000
399	1	36	THR	CB	C	68.698	0.000
400	1	36	THR	CG2	C	22.718	0.000
401	1	36	THR	N	N	121.849	0.000
402	1	37	ASP	H	H	7.599	0.000
403	1	37	ASP	HA	H	4.823	0.000
404	1	37	ASP	HB2	H	2.781	0.000
405	1	37	ASP	HB3	H	2.445	0.000
406	1	37	ASP	CA	C	55.064	0.000
407	1	37	ASP	CB	C	44.267	0.003
408	1	37	ASP	N	N	119.860	0.000
409	1	38	ILE	H	H	7.969	0.000
410	1	38	ILE	HA	H	4.723	0.000
411	1	38	ILE	HB	H	1.745	0.000
412	1	38	ILE	HG12	H	1.750	0.000
413	1	38	ILE	HG13	H	0.965	0.000
414	1	38	ILE	HG21	H	0.738	0.000
415	1	38	ILE	HG22	H	0.738	0.000
416	1	38	ILE	HG23	H	0.738	0.000
417	1	38	ILE	HD11	H	0.967	0.000
418	1	38	ILE	HD12	H	0.967	0.000
419	1	38	ILE	HD13	H	0.967	0.000
420	1	38	ILE	CA	C	61.346	0.000
421	1	38	ILE	CB	C	41.590	0.000
422	1	38	ILE	CG1	C	28.696	0.025
423	1	38	ILE	CG2	C	17.075	0.000
424	1	38	ILE	CD1	C	13.701	0.000
425	1	38	ILE	N	N	122.742	0.000
426	1	39	GLN	H	H	9.030	0.000
427	1	39	GLN	HA	H	4.740	0.000
428	1	39	GLN	HB2	H	2.233	0.000
429	1	39	GLN	HB3	H	2.040	0.000
430	1	39	GLN	HG2	H	2.448	0.000
431	1	39	GLN	HG3	H	2.372	0.000
432	1	39	GLN	HE21	H	8.125	0.000
433	1	39	GLN	HE22	H	6.690	0.000
434	1	39	GLN	CA	C	54.213	0.000
435	1	39	GLN	CB	C	32.170	0.010
436	1	39	GLN	CG	C	33.304	0.005
437	1	39	GLN	N	N	126.060	0.000
438	1	39	GLN	NE2	N	113.257	0.000
439	1	40	ILE	H	H	8.741	0.000
440	1	40	ILE	HA	H	4.455	0.000
441	1	40	ILE	HB	H	1.797	0.000
442	1	40	ILE	HG12	H	1.350	0.000
443	1	40	ILE	HG13	H	0.577	0.000
444	1	40	ILE	HG21	H	0.652	0.000
445	1	40	ILE	HG22	H	0.652	0.000
446	1	40	ILE	HG23	H	0.652	0.000
447	1	40	ILE	HD11	H	0.575	0.000
448	1	40	ILE	HD12	H	0.575	0.000
449	1	40	ILE	HD13	H	0.575	0.000
450	1	40	ILE	CA	C	58.503	0.000
451	1	40	ILE	CB	C	38.722	0.000
452	1	40	ILE	CG1	C	26.663	0.015
453	1	40	ILE	CG2	C	17.552	0.000
454	1	40	ILE	CD1	C	13.260	0.000
455	1	40	ILE	N	N	123.977	0.000
456	1	41	PRO	HA	H	4.368	0.000
457	1	41	PRO	HB2	H	2.498	0.000
458	1	41	PRO	HB3	H	1.633	0.000
459	1	41	PRO	HG2	H	2.037	0.000
460	1	41	PRO	HG3	H	2.037	0.000
461	1	41	PRO	HD2	H	3.655	0.000
462	1	41	PRO	HD3	H	3.223	0.000
463	1	41	PRO	CA	C	63.332	0.000
464	1	41	PRO	CB	C	32.418	0.010
465	1	41	PRO	CG	C	27.962	0.000
466	1	41	PRO	CD	C	50.407	0.001
467	1	42	LEU	H	H	8.332	0.000
468	1	42	LEU	HA	H	4.541	0.000
469	1	42	LEU	HB2	H	1.484	0.000
470	1	42	LEU	HB3	H	1.011	0.000
471	1	42	LEU	HG	H	1.698	0.000
472	1	42	LEU	HD11	H	0.654	0.000
473	1	42	LEU	HD12	H	0.654	0.000
474	1	42	LEU	HD13	H	0.654	0.000
475	1	42	LEU	HD21	H	0.836	0.000
476	1	42	LEU	HD22	H	0.836	0.000
477	1	42	LEU	HD23	H	0.836	0.000
478	1	42	LEU	CA	C	53.435	0.000
479	1	42	LEU	CB	C	44.261	0.000
480	1	42	LEU	CG	C	26.494	0.000
481	1	42	LEU	CD1	C	22.834	0.000
482	1	42	LEU	CD2	C	25.092	0.000
483	1	42	LEU	N	N	121.661	0.000
484	1	43	ASP	H	H	8.572	0.000
485	1	43	ASP	HA	H	4.695	0.000
486	1	43	ASP	HB2	H	3.209	0.000
487	1	43	ASP	HB3	H	2.434	0.000
488	1	43	ASP	CA	C	53.887	0.000
489	1	43	ASP	CB	C	42.422	0.011
490	1	43	ASP	N	N	122.294	0.000
491	1	44	TYR	H	H	8.565	0.000
492	1	44	TYR	HA	H	4.263	0.000
493	1	44	TYR	HB2	H	3.169	0.000
494	1	44	TYR	HB3	H	3.086	0.000
495	1	44	TYR	HD1	H	7.191	0.000
496	1	44	TYR	HD2	H	7.191	0.000
497	1	44	TYR	HE1	H	6.881	0.000
498	1	44	TYR	HE2	H	6.881	0.000
499	1	44	TYR	CA	C	60.558	0.000
500	1	44	TYR	CB	C	37.985	0.002
501	1	44	TYR	CD1	C	132.913	0.000
502	1	44	TYR	CE1	C	118.489	0.000
503	1	44	TYR	N	N	125.895	0.000
504	1	45	GLU	H	H	8.590	0.000
505	1	45	GLU	HA	H	4.268	0.000
506	1	45	GLU	HB2	H	2.189	0.000
507	1	45	GLU	HB3	H	2.189	0.000
508	1	45	GLU	HG2	H	2.344	0.000
509	1	45	GLU	HG3	H	2.255	0.000
510	1	45	GLU	CA	C	58.602	0.000
511	1	45	GLU	CB	C	30.319	0.000
512	1	45	GLU	CG	C	36.753	0.012
513	1	45	GLU	N	N	117.844	0.000
514	1	46	THR	H	H	7.885	0.000
515	1	46	THR	HA	H	4.368	0.000
516	1	46	THR	HB	H	4.318	0.000
517	1	46	THR	HG21	H	1.245	0.000
518	1	46	THR	HG22	H	1.245	0.000
519	1	46	THR	HG23	H	1.245	0.000
520	1	46	THR	CA	C	61.842	0.000
521	1	46	THR	CB	C	70.605	0.000
522	1	46	THR	CG2	C	21.618	0.000
523	1	46	THR	N	N	107.600	0.000
524	1	47	GLU	H	H	8.375	0.000
525	1	47	GLU	HA	H	3.816	0.000
526	1	47	GLU	HB2	H	2.308	0.000
527	1	47	GLU	HB3	H	2.293	0.000
528	1	47	GLU	HG2	H	2.179	0.000
529	1	47	GLU	HG3	H	2.179	0.000
530	1	47	GLU	CA	C	58.188	0.000
531	1	47	GLU	CB	C	27.438	0.000
532	1	47	GLU	CG	C	37.312	0.000
533	1	47	GLU	N	N	116.291	0.000
534	1	48	LYS	H	H	7.690	0.000
535	1	48	LYS	HA	H	4.663	0.000
536	1	48	LYS	HB2	H	1.874	0.000
537	1	48	LYS	HB3	H	1.635	0.000
538	1	48	LYS	HG2	H	1.462	0.000
539	1	48	LYS	HG3	H	1.410	0.000
540	1	48	LYS	HD2	H	1.673	0.000
541	1	48	LYS	HD3	H	1.625	0.000
542	1	48	LYS	HE2	H	3.005	0.000
543	1	48	LYS	HE3	H	3.005	0.000
544	1	48	LYS	CA	C	54.555	0.000
545	1	48	LYS	CB	C	35.299	0.005
546	1	48	LYS	CG	C	24.748	0.008
547	1	48	LYS	CD	C	29.078	0.003
548	1	48	LYS	CE	C	42.285	0.000
549	1	48	LYS	N	N	117.761	0.000
550	1	49	HIS	H	H	8.140	0.000
551	1	49	HIS	HA	H	4.944	0.000
552	1	49	HIS	HB2	H	3.515	0.000
553	1	49	HIS	HB3	H	2.850	0.000
554	1	49	HIS	HD2	H	7.153	0.000
555	1	49	HIS	HE1	H	7.414	0.000
556	1	49	HIS	CA	C	55.802	0.000
557	1	49	HIS	CB	C	30.939	0.001
558	1	49	HIS	CD2	C	118.955	0.000
559	1	49	HIS	CE1	C	138.995	0.000
560	1	49	HIS	N	N	117.961	0.000
561	1	50	ARG	H	H	8.839	0.000
562	1	50	ARG	HA	H	4.517	0.000
563	1	50	ARG	HB2	H	2.452	0.000
564	1	50	ARG	HB3	H	1.597	0.000
565	1	50	ARG	HG2	H	1.702	0.000
566	1	50	ARG	HG3	H	1.564	0.000
567	1	50	ARG	HD2	H	3.192	0.000
568	1	50	ARG	HD3	H	3.056	0.000
569	1	50	ARG	CA	C	55.812	0.000
570	1	50	ARG	CB	C	31.570	0.000
571	1	50	ARG	CG	C	27.408	0.003
572	1	50	ARG	CD	C	44.434	0.000
573	1	50	ARG	N	N	119.137	0.000
574	1	51	GLY	H	H	10.675	0.000
575	1	51	GLY	HA2	H	4.512	0.000
576	1	51	GLY	HA3	H	3.942	0.000
577	1	51	GLY	CA	C	45.565	0.010
578	1	51	GLY	N	N	112.514	0.000
579	1	52	PHE	H	H	6.970	0.000
580	1	52	PHE	HA	H	5.591	0.000
581	1	52	PHE	HB2	H	2.941	0.000
582	1	52	PHE	HB3	H	2.576	0.000
583	1	52	PHE	HD1	H	6.699	0.000
584	1	52	PHE	HD2	H	6.699	0.000
585	1	52	PHE	HE1	H	7.303	0.000
586	1	52	PHE	HE2	H	7.303	0.000
587	1	52	PHE	HZ	H	7.287	0.000
588	1	52	PHE	CA	C	54.753	0.000
589	1	52	PHE	CB	C	42.129	0.001
590	1	52	PHE	CD1	C	132.797	0.000
591	1	52	PHE	CE1	C	131.217	0.000
592	1	52	PHE	CZ	C	128.804	0.000
593	1	52	PHE	N	N	114.720	0.000
594	1	53	ALA	H	H	8.670	0.000
595	1	53	ALA	HA	H	4.486	0.000
596	1	53	ALA	HB1	H	0.890	0.000
597	1	53	ALA	HB2	H	0.890	0.000
598	1	53	ALA	HB3	H	0.890	0.000
599	1	53	ALA	CA	C	49.909	0.000
600	1	53	ALA	CB	C	25.894	0.000
601	1	53	ALA	N	N	119.850	0.000
602	1	54	PHE	H	H	8.679	0.000
603	1	54	PHE	HA	H	5.850	0.000
604	1	54	PHE	HB2	H	2.822	0.000
605	1	54	PHE	HB3	H	2.640	0.000
606	1	54	PHE	HD1	H	7.024	0.000
607	1	54	PHE	HD2	H	7.024	0.000
608	1	54	PHE	HE1	H	7.364	0.000
609	1	54	PHE	HE2	H	7.364	0.000
610	1	54	PHE	HZ	H	7.249	0.000
611	1	54	PHE	CA	C	55.895	0.000
612	1	54	PHE	CB	C	41.816	0.000
613	1	54	PHE	CD1	C	131.684	0.000
614	1	54	PHE	CE1	C	130.546	0.000
615	1	54	PHE	CZ	C	129.035	0.000
616	1	54	PHE	N	N	114.399	0.000
617	1	55	VAL	H	H	8.774	0.000
618	1	55	VAL	HA	H	4.332	0.000
619	1	55	VAL	HB	H	1.456	0.000
620	1	55	VAL	HG11	H	0.315	0.000
621	1	55	VAL	HG12	H	0.315	0.000
622	1	55	VAL	HG13	H	0.315	0.000
623	1	55	VAL	HG21	H	0.296	0.000
624	1	55	VAL	HG22	H	0.296	0.000
625	1	55	VAL	HG23	H	0.296	0.000
626	1	55	VAL	CA	C	61.213	0.000
627	1	55	VAL	CB	C	34.843	0.000
628	1	55	VAL	CG1	C	20.291	0.000
629	1	55	VAL	CG2	C	21.209	0.000
630	1	55	VAL	N	N	123.042	0.000
631	1	56	GLU	H	H	9.044	0.000
632	1	56	GLU	HA	H	5.192	0.000
633	1	56	GLU	HB2	H	2.145	0.000
634	1	56	GLU	HB3	H	1.815	0.000
635	1	56	GLU	HG2	H	2.105	0.000
636	1	56	GLU	HG3	H	1.992	0.000
637	1	56	GLU	CA	C	54.466	0.000
638	1	56	GLU	CB	C	33.125	0.005
639	1	56	GLU	CG	C	36.762	0.004
640	1	56	GLU	N	N	129.405	0.000
641	1	57	PHE	H	H	8.754	0.000
642	1	57	PHE	HA	H	4.918	0.000
643	1	57	PHE	HB2	H	3.782	0.000
644	1	57	PHE	HB3	H	2.748	0.000
645	1	57	PHE	HD1	H	7.245	0.000
646	1	57	PHE	HD2	H	7.245	0.000
647	1	57	PHE	HE1	H	7.598	0.000
648	1	57	PHE	HE2	H	7.598	0.000
649	1	57	PHE	HZ	H	7.226	0.000
650	1	57	PHE	CA	C	58.157	0.000
651	1	57	PHE	CB	C	41.431	0.041
652	1	57	PHE	CD1	C	131.388	0.000
653	1	57	PHE	CE1	C	129.061	0.000
654	1	57	PHE	CZ	C	129.502	0.000
655	1	57	PHE	N	N	126.527	0.000
656	1	58	GLU	H	H	8.174	0.000
657	1	58	GLU	HA	H	4.027	0.000
658	1	58	GLU	HB2	H	2.341	0.000
659	1	58	GLU	HB3	H	2.083	0.000
660	1	58	GLU	HG2	H	2.284	0.000
661	1	58	GLU	HG3	H	2.284	0.000
662	1	58	GLU	CA	C	59.848	0.000
663	1	58	GLU	CB	C	30.044	0.002
664	1	58	GLU	CG	C	36.192	0.000
665	1	58	GLU	N	N	121.274	0.000
666	1	59	LEU	H	H	9.335	0.000
667	1	59	LEU	HA	H	4.919	0.000
668	1	59	LEU	HB2	H	1.922	0.000
669	1	59	LEU	HB3	H	1.697	0.000
670	1	59	LEU	HG	H	1.781	0.000
671	1	59	LEU	HD11	H	1.040	0.000
672	1	59	LEU	HD12	H	1.040	0.000
673	1	59	LEU	HD13	H	1.040	0.000
674	1	59	LEU	HD21	H	1.115	0.000
675	1	59	LEU	HD22	H	1.115	0.000
676	1	59	LEU	HD23	H	1.115	0.000
677	1	59	LEU	CA	C	53.025	0.000
678	1	59	LEU	CB	C	43.280	0.002
679	1	59	LEU	CG	C	26.972	0.000
680	1	59	LEU	CD1	C	23.253	0.000
681	1	59	LEU	CD2	C	25.294	0.000
682	1	59	LEU	N	N	116.347	0.000
683	1	60	ALA	H	H	9.053	0.000
684	1	60	ALA	HA	H	4.004	0.000
685	1	60	ALA	HB1	H	1.470	0.000
686	1	60	ALA	HB2	H	1.470	0.000
687	1	60	ALA	HB3	H	1.470	0.000
688	1	60	ALA	CA	C	55.246	0.000
689	1	60	ALA	CB	C	18.576	0.000
690	1	60	ALA	N	N	127.185	0.000
691	1	61	GLU	H	H	9.994	0.000
692	1	61	GLU	HA	H	4.135	0.000
693	1	61	GLU	HB2	H	2.099	0.000
694	1	61	GLU	HB3	H	2.099	0.000
695	1	61	GLU	HG2	H	2.512	0.000
696	1	61	GLU	HG3	H	2.407	0.000
697	1	61	GLU	CA	C	59.844	0.000
698	1	61	GLU	CB	C	28.649	0.000
699	1	61	GLU	CG	C	36.760	0.012
700	1	61	GLU	N	N	118.621	0.000
701	1	62	ASP	H	H	6.862	0.000
702	1	62	ASP	HA	H	4.516	0.000
703	1	62	ASP	HB2	H	2.987	0.000
704	1	62	ASP	HB3	H	2.679	0.000
705	1	62	ASP	CA	C	56.530	0.000
706	1	62	ASP	CB	C	39.986	0.006
707	1	62	ASP	N	N	123.961	0.000
708	1	63	ALA	H	H	7.011	0.000
709	1	63	ALA	HA	H	3.185	0.000
710	1	63	ALA	HB1	H	1.432	0.000
711	1	63	ALA	HB2	H	1.432	0.000
712	1	63	ALA	HB3	H	1.432	0.000
713	1	63	ALA	CA	C	54.529	0.000
714	1	63	ALA	CB	C	17.421	0.000
715	1	63	ALA	N	N	121.761	0.000
716	1	64	ALA	H	H	7.820	0.000
717	1	64	ALA	HA	H	3.947	0.000
718	1	64	ALA	HB1	H	1.502	0.000
719	1	64	ALA	HB2	H	1.502	0.000
720	1	64	ALA	HB3	H	1.502	0.000
721	1	64	ALA	CA	C	55.032	0.000
722	1	64	ALA	CB	C	17.868	0.000
723	1	64	ALA	N	N	117.697	0.000
724	1	65	ALA	H	H	7.365	0.000
725	1	65	ALA	HA	H	4.180	0.000
726	1	65	ALA	HB1	H	1.714	0.000
727	1	65	ALA	HB2	H	1.714	0.000
728	1	65	ALA	HB3	H	1.714	0.000
729	1	65	ALA	CA	C	54.743	0.000
730	1	65	ALA	CB	C	18.191	0.000
731	1	65	ALA	N	N	121.278	0.000
732	1	66	ALA	H	H	7.876	0.000
733	1	66	ALA	HA	H	2.504	0.000
734	1	66	ALA	HB1	H	1.238	0.000
735	1	66	ALA	HB2	H	1.238	0.000
736	1	66	ALA	HB3	H	1.238	0.000
737	1	66	ALA	CA	C	54.725	0.000
738	1	66	ALA	CB	C	19.018	0.000
739	1	66	ALA	N	N	122.108	0.000
740	1	67	ILE	H	H	7.880	0.000
741	1	67	ILE	HA	H	3.309	0.000
742	1	67	ILE	HB	H	1.914	0.000
743	1	67	ILE	HG12	H	1.931	0.000
744	1	67	ILE	HG13	H	0.616	0.000
745	1	67	ILE	HG21	H	1.009	0.000
746	1	67	ILE	HG22	H	1.009	0.000
747	1	67	ILE	HG23	H	1.009	0.000
748	1	67	ILE	HD11	H	0.876	0.000
749	1	67	ILE	HD12	H	0.876	0.000
750	1	67	ILE	HD13	H	0.876	0.000
751	1	67	ILE	CA	C	66.660	0.000
752	1	67	ILE	CB	C	38.488	0.000
753	1	67	ILE	CG1	C	30.263	0.001
754	1	67	ILE	CG2	C	17.350	0.000
755	1	67	ILE	CD1	C	14.036	0.000
756	1	67	ILE	N	N	118.707	0.000
757	1	68	ASP	H	H	7.466	0.000
758	1	68	ASP	HA	H	4.367	0.000
759	1	68	ASP	HB2	H	2.692	0.000
760	1	68	ASP	HB3	H	2.692	0.000
761	1	68	ASP	CA	C	57.163	0.000
762	1	68	ASP	CB	C	40.956	0.000
763	1	68	ASP	N	N	116.665	0.000
764	1	69	ASN	H	H	7.470	0.000
765	1	69	ASN	HA	H	4.698	0.000
766	1	69	ASN	HB2	H	2.637	0.000
767	1	69	ASN	HB3	H	2.429	0.000
768	1	69	ASN	HD21	H	7.741	0.000
769	1	69	ASN	HD22	H	7.313	0.000
770	1	69	ASN	CA	C	55.479	0.000
771	1	69	ASN	CB	C	42.401	0.010
772	1	69	ASN	N	N	112.774	0.000
773	1	69	ASN	ND2	N	115.380	0.000
774	1	70	MET	H	H	8.293	0.000
775	1	70	MET	HA	H	4.931	0.000
776	1	70	MET	HB2	H	2.088	0.000
777	1	70	MET	HB3	H	1.902	0.000
778	1	70	MET	HG2	H	2.166	0.000
779	1	70	MET	HG3	H	1.778	0.000
780	1	70	MET	HE1	H	1.464	0.000
781	1	70	MET	HE2	H	1.464	0.000
782	1	70	MET	HE3	H	1.464	0.000
783	1	70	MET	CA	C	53.810	0.000
784	1	70	MET	CB	C	33.529	0.018
785	1	70	MET	CG	C	32.920	0.013
786	1	70	MET	CE	C	16.674	0.000
787	1	70	MET	N	N	113.729	0.000
788	1	71	ASN	H	H	8.210	0.000
789	1	71	ASN	HA	H	4.448	0.000
790	1	71	ASN	HB2	H	3.333	0.000
791	1	71	ASN	HB3	H	3.050	0.000
792	1	71	ASN	HD21	H	7.979	0.000
793	1	71	ASN	HD22	H	7.159	0.000
794	1	71	ASN	CA	C	56.923	0.000
795	1	71	ASN	CB	C	38.798	0.006
796	1	71	ASN	N	N	119.543	0.000
797	1	71	ASN	ND2	N	116.051	0.003
798	1	72	GLU	H	H	8.659	0.000
799	1	72	GLU	HA	H	4.038	0.000
800	1	72	GLU	HB2	H	2.388	0.000
801	1	72	GLU	HB3	H	2.280	0.000
802	1	72	GLU	HG2	H	2.347	0.000
803	1	72	GLU	HG3	H	2.226	0.000
804	1	72	GLU	CA	C	58.891	0.000
805	1	72	GLU	CB	C	26.766	0.004
806	1	72	GLU	CG	C	37.180	0.001
807	1	72	GLU	N	N	121.535	0.000
808	1	73	SER	H	H	7.714	0.000
809	1	73	SER	HA	H	4.673	0.000
810	1	73	SER	HB2	H	4.131	0.000
811	1	73	SER	HB3	H	3.904	0.000
812	1	73	SER	CA	C	58.132	0.000
813	1	73	SER	CB	C	65.060	0.000
814	1	73	SER	N	N	115.015	0.000
815	1	74	GLU	H	H	8.308	0.000
816	1	74	GLU	HA	H	5.032	0.000
817	1	74	GLU	HB2	H	1.905	0.000
818	1	74	GLU	HB3	H	1.878	0.000
819	1	74	GLU	HG2	H	2.150	0.000
820	1	74	GLU	HG3	H	1.971	0.000
821	1	74	GLU	CA	C	55.394	0.000
822	1	74	GLU	CB	C	31.952	0.008
823	1	74	GLU	CG	C	36.700	0.008
824	1	74	GLU	N	N	118.047	0.000
825	1	75	LEU	H	H	9.059	0.000
826	1	75	LEU	HA	H	4.645	0.000
827	1	75	LEU	HB2	H	1.805	0.000
828	1	75	LEU	HB3	H	1.428	0.000
829	1	75	LEU	HG	H	1.784	0.000
830	1	75	LEU	HD11	H	0.899	0.000
831	1	75	LEU	HD12	H	0.899	0.000
832	1	75	LEU	HD13	H	0.899	0.000
833	1	75	LEU	HD21	H	0.783	0.000
834	1	75	LEU	HD22	H	0.783	0.000
835	1	75	LEU	HD23	H	0.783	0.000
836	1	75	LEU	CA	C	54.692	0.000
837	1	75	LEU	CB	C	44.987	0.001
838	1	75	LEU	CG	C	26.863	0.000
839	1	75	LEU	CD1	C	23.652	0.000
840	1	75	LEU	CD2	C	25.255	0.000
841	1	75	LEU	N	N	126.839	0.000
842	1	76	PHE	H	H	9.797	0.000
843	1	76	PHE	HA	H	4.017	0.000
844	1	76	PHE	HB2	H	3.565	0.000
845	1	76	PHE	HB3	H	2.802	0.000
846	1	76	PHE	HD1	H	7.184	0.000
847	1	76	PHE	HD2	H	7.184	0.000
848	1	76	PHE	HE1	H	7.351	0.000
849	1	76	PHE	HE2	H	7.351	0.000
850	1	76	PHE	HZ	H	7.347	0.000
851	1	76	PHE	CA	C	59.430	0.000
852	1	76	PHE	CB	C	37.156	0.001
853	1	76	PHE	CD1	C	131.073	0.000
854	1	76	PHE	CE1	C	131.639	0.000
855	1	76	PHE	CZ	C	129.754	0.000
856	1	76	PHE	N	N	128.630	0.000
857	1	77	GLY	H	H	8.709	0.000
858	1	77	GLY	HA2	H	4.146	0.000
859	1	77	GLY	HA3	H	3.722	0.000
860	1	77	GLY	CA	C	45.833	0.006
861	1	77	GLY	N	N	102.210	0.000
862	1	78	ARG	H	H	7.620	0.000
863	1	78	ARG	HA	H	4.860	0.000
864	1	78	ARG	HB2	H	2.139	0.000
865	1	78	ARG	HB3	H	1.895	0.000
866	1	78	ARG	HG2	H	1.785	0.000
867	1	78	ARG	HG3	H	1.785	0.000
868	1	78	ARG	HD2	H	3.247	0.000
869	1	78	ARG	HD3	H	3.247	0.000
870	1	78	ARG	CA	C	53.828	0.000
871	1	78	ARG	CB	C	33.219	0.008
872	1	78	ARG	CG	C	26.759	0.000
873	1	78	ARG	CD	C	43.096	0.000
874	1	78	ARG	N	N	119.236	0.000
875	1	79	THR	H	H	8.448	0.000
876	1	79	THR	HA	H	4.686	0.000
877	1	79	THR	HB	H	3.976	0.000
878	1	79	THR	HG21	H	1.181	0.000
879	1	79	THR	HG22	H	1.181	0.000
880	1	79	THR	HG23	H	1.181	0.000
881	1	79	THR	CA	C	62.972	0.000
882	1	79	THR	CB	C	69.419	0.000
883	1	79	THR	CG2	C	21.989	0.000
884	1	79	THR	N	N	119.089	0.000
885	1	80	ILE	H	H	8.813	0.000
886	1	80	ILE	HA	H	5.175	0.000
887	1	80	ILE	HB	H	1.979	0.000
888	1	80	ILE	HG12	H	1.557	0.000
889	1	80	ILE	HG13	H	1.290	0.000
890	1	80	ILE	HG21	H	0.895	0.000
891	1	80	ILE	HG22	H	0.895	0.000
892	1	80	ILE	HG23	H	0.895	0.000
893	1	80	ILE	HD11	H	0.711	0.000
894	1	80	ILE	HD12	H	0.711	0.000
895	1	80	ILE	HD13	H	0.711	0.000
896	1	80	ILE	CA	C	60.048	0.000
897	1	80	ILE	CB	C	40.607	0.000
898	1	80	ILE	CG1	C	24.824	0.006
899	1	80	ILE	CG2	C	19.055	0.000
900	1	80	ILE	CD1	C	14.260	0.000
901	1	80	ILE	N	N	121.621	0.000
902	1	81	ARG	H	H	8.258	0.000
903	1	81	ARG	HA	H	5.058	0.000
904	1	81	ARG	HB2	H	1.889	0.000
905	1	81	ARG	HB3	H	1.764	0.000
906	1	81	ARG	HG2	H	1.757	0.000
907	1	81	ARG	HG3	H	1.717	0.000
908	1	81	ARG	HD2	H	3.338	0.000
909	1	81	ARG	HD3	H	3.338	0.000
910	1	81	ARG	CA	C	53.841	0.000
911	1	81	ARG	CB	C	32.512	0.013
912	1	81	ARG	CG	C	27.273	0.001
913	1	81	ARG	CD	C	43.209	0.000
914	1	81	ARG	N	N	122.003	0.000
915	1	82	VAL	H	H	8.966	0.000
916	1	82	VAL	HA	H	5.452	0.000
917	1	82	VAL	HB	H	1.873	0.000
918	1	82	VAL	HG11	H	1.081	0.000
919	1	82	VAL	HG12	H	1.081	0.000
920	1	82	VAL	HG13	H	1.081	0.000
921	1	82	VAL	HG21	H	1.065	0.000
922	1	82	VAL	HG22	H	1.065	0.000
923	1	82	VAL	HG23	H	1.065	0.000
924	1	82	VAL	CA	C	60.404	0.000
925	1	82	VAL	CB	C	35.178	0.000
926	1	82	VAL	CG1	C	22.493	0.000
927	1	82	VAL	CG2	C	24.445	0.000
928	1	82	VAL	N	N	122.975	0.000
929	1	83	ASN	H	H	9.065	0.000
930	1	83	ASN	HA	H	4.918	0.000
931	1	83	ASN	HB2	H	3.067	0.000
932	1	83	ASN	HB3	H	2.860	0.000
933	1	83	ASN	HD21	H	7.406	0.000
934	1	83	ASN	HD22	H	7.016	0.000
935	1	83	ASN	CA	C	51.780	0.000
936	1	83	ASN	CB	C	42.551	0.005
937	1	83	ASN	N	N	121.571	0.000
938	1	83	ASN	ND2	N	112.215	0.001
939	1	84	LEU	H	H	8.842	0.000
940	1	84	LEU	HA	H	4.561	0.000
941	1	84	LEU	HB2	H	1.756	0.000
942	1	84	LEU	HB3	H	1.665	0.000
943	1	84	LEU	HG	H	1.781	0.000
944	1	84	LEU	HD11	H	1.023	0.000
945	1	84	LEU	HD12	H	1.023	0.000
946	1	84	LEU	HD13	H	1.023	0.000
947	1	84	LEU	HD21	H	0.899	0.000
948	1	84	LEU	HD22	H	0.899	0.000
949	1	84	LEU	HD23	H	0.899	0.000
950	1	84	LEU	CA	C	56.407	0.000
951	1	84	LEU	CB	C	42.269	0.007
952	1	84	LEU	CG	C	26.901	0.000
953	1	84	LEU	CD1	C	25.499	0.000
954	1	84	LEU	CD2	C	23.587	0.000
955	1	84	LEU	N	N	121.384	0.000
956	1	85	ALA	H	H	8.797	0.000
957	1	85	ALA	HA	H	4.745	0.000
958	1	85	ALA	HB1	H	1.528	0.000
959	1	85	ALA	HB2	H	1.528	0.000
960	1	85	ALA	HB3	H	1.528	0.000
961	1	85	ALA	CA	C	52.216	0.000
962	1	85	ALA	CB	C	19.784	0.000
963	1	85	ALA	N	N	126.378	0.000
964	1	86	LYS	H	H	8.876	0.000
965	1	86	LYS	HA	H	4.575	0.000
966	1	86	LYS	HB2	H	1.798	0.000
967	1	86	LYS	HB3	H	1.610	0.000
968	1	86	LYS	HG2	H	1.417	0.000
969	1	86	LYS	HG3	H	1.417	0.000
970	1	86	LYS	HD2	H	1.576	0.000
971	1	86	LYS	HD3	H	1.494	0.000
972	1	86	LYS	HE2	H	2.823	0.000
973	1	86	LYS	HE3	H	2.823	0.000
974	1	86	LYS	CA	C	54.584	0.000
975	1	86	LYS	CB	C	32.243	0.008
976	1	86	LYS	CG	C	25.028	0.000
977	1	86	LYS	CD	C	29.189	0.004
978	1	86	LYS	CE	C	42.051	0.000
979	1	86	LYS	N	N	123.058	0.000
980	1	87	PRO	HA	H	4.433	0.000
981	1	87	PRO	HB2	H	2.280	0.000
982	1	87	PRO	HB3	H	1.881	0.000
983	1	87	PRO	HG2	H	2.050	0.000
984	1	87	PRO	HG3	H	1.992	0.000
985	1	87	PRO	HD2	H	3.823	0.000
986	1	87	PRO	HD3	H	3.630	0.000
987	1	87	PRO	CA	C	63.027	0.000
988	1	87	PRO	CB	C	31.983	0.002
989	1	87	PRO	CG	C	27.574	0.006
990	1	87	PRO	CD	C	50.406	0.002
991	1	88	MET	H	H	8.309	0.000
992	1	88	MET	HA	H	4.333	0.000
993	1	88	MET	HB2	H	1.952	0.000
994	1	88	MET	HB3	H	1.877	0.000
995	1	88	MET	HG2	H	2.410	0.000
996	1	88	MET	HG3	H	2.410	0.000
997	1	88	MET	HE1	H	1.909	0.000
998	1	88	MET	HE2	H	1.909	0.000
999	1	88	MET	HE3	H	1.909	0.000
1000	1	88	MET	CA	C	55.840	0.000
1001	1	88	MET	CB	C	33.513	0.005
1002	1	88	MET	CG	C	31.990	0.000
1003	1	88	MET	CE	C	16.943	0.000
1004	1	88	MET	N	N	121.038	0.000
1005	1	89	ARG	H	H	8.459	0.000
1006	1	89	ARG	HA	H	4.345	0.000
1007	1	89	ARG	HB2	H	1.807	0.000
1008	1	89	ARG	HB3	H	1.764	0.000
1009	1	89	ARG	HG2	H	1.626	0.000
1010	1	89	ARG	HG3	H	1.570	0.000
1011	1	89	ARG	HD2	H	3.164	0.000
1012	1	89	ARG	HD3	H	3.164	0.000
1013	1	89	ARG	CA	C	56.044	0.000
1014	1	89	ARG	CB	C	30.785	0.004
1015	1	89	ARG	CG	C	27.221	0.009
1016	1	89	ARG	CD	C	43.397	0.000
1017	1	89	ARG	N	N	122.764	0.000
1018	1	90	ILE	H	H	8.164	0.000
1019	1	90	ILE	HA	H	4.182	0.000
1020	1	90	ILE	HB	H	1.859	0.000
1021	1	90	ILE	HG12	H	1.457	0.000
1022	1	90	ILE	HG13	H	1.175	0.000
1023	1	90	ILE	HG21	H	0.906	0.000
1024	1	90	ILE	HG22	H	0.906	0.000
1025	1	90	ILE	HG23	H	0.906	0.000
1026	1	90	ILE	HD11	H	0.851	0.000
1027	1	90	ILE	HD12	H	0.851	0.000
1028	1	90	ILE	HD13	H	0.851	0.000
1029	1	90	ILE	CA	C	60.920	0.000
1030	1	90	ILE	CB	C	38.818	0.000
1031	1	90	ILE	CG1	C	27.294	0.008
1032	1	90	ILE	CG2	C	17.571	0.000
1033	1	90	ILE	CD1	C	12.876	0.000
1034	1	90	ILE	N	N	122.492	0.000
1035	1	91	LYS	H	H	8.354	0.000
1036	1	91	LYS	HA	H	4.358	0.000
1037	1	91	LYS	HB2	H	1.863	0.000
1038	1	91	LYS	HB3	H	1.781	0.000
1039	1	91	LYS	HG2	H	1.462	0.000
1040	1	91	LYS	HG3	H	1.415	0.000
1041	1	91	LYS	HD2	H	1.707	0.000
1042	1	91	LYS	HD3	H	1.707	0.000
1043	1	91	LYS	HE2	H	3.033	0.000
1044	1	91	LYS	HE3	H	3.033	0.000
1045	1	91	LYS	CA	C	56.331	0.000
1046	1	91	LYS	CB	C	33.152	0.002
1047	1	91	LYS	CG	C	24.735	0.005
1048	1	91	LYS	CD	C	29.106	0.000
1049	1	91	LYS	CE	C	42.242	0.000
1050	1	91	LYS	N	N	125.822	0.000
1051	1	92	GLU	H	H	8.435	0.000
1052	1	92	GLU	HA	H	4.376	0.000
1053	1	92	GLU	HB2	H	2.120	0.000
1054	1	92	GLU	HB3	H	1.982	0.000
1055	1	92	GLU	HG2	H	2.291	0.000
1056	1	92	GLU	HG3	H	2.291	0.000
1057	1	92	GLU	CA	C	56.538	0.000
1058	1	92	GLU	CB	C	30.722	0.006
1059	1	92	GLU	CG	C	36.453	0.000
1060	1	92	GLU	N	N	123.530	0.000
1061	1	93	GLY	H	H	7.985	0.000
1062	1	93	GLY	HA2	H	3.816	0.000
1063	1	93	GLY	HA3	H	3.801	0.000
1064	1	93	GLY	CA	C	46.192	0.011
1065	1	93	GLY	N	N	116.336	0.000
1066	2	1	U	H1'	H	5.819	0.000
1067	2	1	U	H2'	H	4.369	0.000
1068	2	1	U	H3'	H	4.572	0.000
1069	2	1	U	H4'	H	4.252	0.000
1070	2	1	U	H5	H	5.775	0.000
1071	2	1	U	H5'	H	3.829	0.000
1072	2	1	U	H5''	H	3.804	0.000
1073	2	1	U	H6	H	7.779	0.000
1074	2	1	U	C1'	C	91.932	0.000
1075	2	1	U	C2'	C	75.722	0.000
1076	2	1	U	C3'	C	75.966	0.000
1077	2	1	U	C4'	C	86.152	0.000
1078	2	1	U	C5	C	104.866	0.000
1079	2	1	U	C5'	C	63.172	0.003
1080	2	1	U	C6	C	144.114	0.000
1081	2	2	A	H1'	H	5.979	0.000
1082	2	2	A	H2	H	8.105	0.000
1083	2	2	A	H2'	H	4.802	0.000
1084	2	2	A	H3'	H	4.838	0.000
1085	2	2	A	H4'	H	4.520	0.000
1086	2	2	A	H5'	H	4.258	0.000
1087	2	2	A	H5''	H	4.173	0.000
1088	2	2	A	H8	H	8.359	0.000
1089	2	2	A	C1'	C	90.600	0.000
1090	2	2	A	C2	C	155.330	0.000
1091	2	2	A	C2'	C	75.904	0.000
1092	2	2	A	C3'	C	76.334	0.000
1093	2	2	A	C4'	C	84.819	0.000
1094	2	2	A	C5'	C	67.434	0.007
1095	2	2	A	C8	C	142.048	0.000
1096	2	3	A	H1'	H	6.030	0.000
1097	2	3	A	H2	H	8.182	0.000
1098	2	3	A	H2'	H	4.753	0.000
1099	2	3	A	H3'	H	4.831	0.000
1100	2	3	A	H4'	H	4.569	0.000
1101	2	3	A	H5'	H	4.391	0.000
1102	2	3	A	H5''	H	4.263	0.000
1103	2	3	A	H8	H	8.339	0.000
1104	2	3	A	C1'	C	90.265	0.000
1105	2	3	A	C2	C	155.491	0.000
1106	2	3	A	C2'	C	76.402	0.000
1107	2	3	A	C3'	C	76.369	0.000
1108	2	3	A	C4'	C	85.144	0.000
1109	2	3	A	C5'	C	67.468	0.004
1110	2	3	A	C8	C	141.802	0.000
1111	2	4	U	H1'	H	5.879	0.000
1112	2	4	U	H2'	H	4.335	0.000
1113	2	4	U	H3'	H	4.662	0.000
1114	2	4	U	H4'	H	4.341	0.000
1115	2	4	U	H5	H	5.654	0.000
1116	2	4	U	H5'	H	4.195	0.000
1117	2	4	U	H5''	H	4.071	0.000
1118	2	4	U	H6	H	7.678	0.000
1119	2	4	U	C1'	C	90.785	0.000
1120	2	4	U	C2'	C	75.804	0.000
1121	2	4	U	C3'	C	76.888	0.000
1122	2	4	U	C4'	C	85.134	0.000
1123	2	4	U	C5	C	105.207	0.000
1124	2	4	U	C5'	C	67.548	0.001
1125	2	4	U	C6	C	143.325	0.000
1126	2	5	G	H1'	H	5.869	0.000
1127	2	5	G	H2'	H	4.846	0.000
1128	2	5	G	H3'	H	4.945	0.000
1129	2	5	G	H4'	H	4.535	0.000
1130	2	5	G	H5'	H	4.307	0.000
1131	2	5	G	H5''	H	4.201	0.000
1132	2	5	G	H8	H	7.991	0.000
1133	2	5	G	C1'	C	90.538	0.000
1134	2	5	G	C2'	C	77.393	0.000
1135	2	5	G	C3'	C	75.207	0.000
1136	2	5	G	C4'	C	85.599	0.000
1137	2	5	G	C5'	C	67.861	0.007
1138	2	5	G	C8	C	140.391	0.000
1139	2	6	U	H1'	H	5.947	0.000
1140	2	6	U	H2'	H	4.436	0.000
1141	2	6	U	H3'	H	4.670	0.000
1142	2	6	U	H4'	H	4.461	0.000
1143	2	6	U	H5	H	5.819	0.000
1144	2	6	U	H5'	H	4.282	0.000
1145	2	6	U	H5''	H	4.206	0.000
1146	2	6	U	H6	H	7.833	0.000
1147	2	6	U	C1'	C	91.111	0.000
1148	2	6	U	C2'	C	75.680	0.000
1149	2	6	U	C3'	C	76.521	0.000
1150	2	6	U	C4'	C	85.337	0.000
1151	2	6	U	C5	C	105.231	0.000
1152	2	6	U	C5'	C	67.486	0.001
1153	2	6	U	C6	C	143.673	0.000
1154	2	7	C	H1'	H	5.996	0.000
1155	2	7	C	H2'	H	4.356	0.000
1156	2	7	C	H3'	H	4.650	0.000
1157	2	7	C	H4'	H	4.377	0.000
1158	2	7	C	H5	H	5.945	0.000
1159	2	7	C	H5'	H	4.154	0.000
1160	2	7	C	H5''	H	4.124	0.000
1161	2	7	C	H6	H	7.800	0.000
1162	2	7	C	C1'	C	91.724	0.000
1163	2	7	C	C2'	C	76.290	0.000
1164	2	7	C	C3'	C	76.177	0.000
1165	2	7	C	C4'	C	84.300	0.000
1166	2	7	C	C5	C	98.996	0.000
1167	2	7	C	C5'	C	67.132	0.003
1168	2	7	C	C6	C	143.317	0.000
1169	2	8	G	H1'	H	5.904	0.000
1170	2	8	G	H2'	H	4.536	0.000
1171	2	8	G	H3'	H	4.757	0.000
1172	2	8	G	H4'	H	4.375	0.000
1173	2	8	G	H5'	H	4.296	0.000
1174	2	8	G	H5''	H	4.210	0.000
1175	2	8	G	H8	H	8.042	0.000
1176	2	8	G	C1'	C	90.394	0.000
1177	2	8	G	C2'	C	73.102	0.000
1178	2	8	G	C3'	C	76.431	0.000
1179	2	8	G	C4'	C	86.344	0.000
1180	2	8	G	C5'	C	67.798	0.003
1181	2	8	G	C8	C	140.353	0.000

Release date

2022-04-05

Citation

RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription
Blatter, M., Meylan, C., Clery, A., Giambruno, R., Nikolaev, Y., Heidecker, M., Solanki, J.A., Diaz, M.O., Gabellini, D., Allain, F.H.
Sci. Adv. (2023), 9, eadf5330-eadf5330, PubMed 37075125 , DOI 10.1126/sciadv.adf5330 , Abstract