BMRB: 34843

RNA G-quadruplex from the 5'-UTR of human tyrosine kinase 2 (TYK2)

Authors

Toplishek, M., Kocman, V.

Assembly

RNA (5'-R(*CP*GP*GP*UP*AP*GP*CP*GP*GP*GP*UP*AP*UP*GP*GP*GP*UP*CP*CP*GP*GP*GP*U)-3')

Entity

1. RNA (5'-R(*CP*GP*GP*UP*AP*GP*CP*GP*GP*GP*UP*AP*UP*GP*GP*GP*UP*CP*CP*GP*GP*GP*U)-3') (polymer, Thiol state: not present), 23 monomers, 7570.451 Da Detail

CGGUAGCGGG UAUGGGUCCG GGU

Formula weight

7570.451 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chemcal Shifts

¹H: 113 assignments Detail

Download

• NMR-STAR v3.1 (partial)
• BMRB/XML (partial)
• CSV
• TSV

ID	Entity ID	Seq ID	Comp ID	Atom ID	Atom type	Val	Val err	Ambig. code
1	1	1	C	H1'	H	5.458	0.000	1
2	1	1	C	H2'	H	4.222	0.000	1
3	1	1	C	H3'	H	4.357	0.000	1
4	1	1	C	H5	H	5.473	0.008	1
5	1	1	C	H6	H	7.623	0.002	1
6	1	2	G	H1	H	11.740	0.001	1
7	1	2	G	H1'	H	5.654	0.001	1
8	1	2	G	H2'	H	4.841	0.001	1
9	1	2	G	H3'	H	4.788	0.002	1
10	1	2	G	H4'	H	4.514	0.000	1
11	1	2	G	H8	H	8.038	0.002	1
12	1	3	G	H1	H	11.525	0.001	1
13	1	3	G	H1'	H	6.088	0.003	1
14	1	3	G	H2'	H	4.427	0.002	1
15	1	3	G	H3'	H	4.787	0.002	1
16	1	3	G	H8	H	7.951	0.001	1
17	1	4	U	H1'	H	6.027	0.000	1
18	1	4	U	H5	H	5.963	0.001	1
19	1	4	U	H6	H	8.014	0.001	1
20	1	5	A	H1'	H	5.556	0.001	1
21	1	5	A	H2	H	7.301	0.004	1
22	1	5	A	H2'	H	3.807	0.001	1
23	1	5	A	H3'	H	4.328	0.000	1
24	1	5	A	H4'	H	3.994	0.000	1
25	1	5	A	H5'	H	2.873	0.000	2
26	1	5	A	H5''	H	3.255	0.000	2
27	1	5	A	H8	H	7.985	0.001	1
28	1	6	G	H1	H	10.642	0.002	1
29	1	6	G	H1'	H	5.926	0.002	1
30	1	6	G	H2'	H	6.188	0.002	1
31	1	6	G	H3'	H	5.050	0.001	1
32	1	6	G	H8	H	7.743	0.001	1
33	1	7	C	H1'	H	6.269	0.001	1
34	1	7	C	H2'	H	4.633	0.001	1
35	1	7	C	H3'	H	4.909	0.000	1
36	1	7	C	H4'	H	4.524	0.000	1
37	1	7	C	H5	H	6.210	0.000	1
38	1	7	C	H6	H	8.037	0.002	1
39	1	8	G	H1	H	11.458	0.003	1
40	1	8	G	H1'	H	5.805	0.001	1
41	1	8	G	H2'	H	4.899	0.001	1
42	1	8	G	H3'	H	4.788	0.000	1
43	1	8	G	H4'	H	4.545	0.000	1
44	1	8	G	H8	H	7.942	0.002	1
45	1	9	G	H1	H	11.434	0.005	1
46	1	9	G	H1'	H	5.893	0.000	1
47	1	9	G	H2'	H	4.534	0.002	1
48	1	9	G	H8	H	7.808	0.001	1
49	1	10	G	H1	H	10.901	0.002	1
50	1	10	G	H1'	H	5.881	0.003	1
51	1	10	G	H2'	H	4.604	0.000	1
52	1	10	G	H3'	H	4.780	0.000	1
53	1	10	G	H8	H	7.989	0.002	1
54	1	11	U	H1'	H	5.941	0.001	1
55	1	11	U	H2'	H	4.423	0.003	1
56	1	11	U	H3'	H	4.641	0.002	1
57	1	11	U	H5	H	5.991	0.000	1
58	1	11	U	H6	H	7.875	0.001	1
59	1	12	A	H1'	H	6.208	0.001	1
60	1	12	A	H2	H	8.304	0.000	1
61	1	12	A	H2'	H	4.955	0.001	1
62	1	12	A	H3'	H	4.900	0.000	1
63	1	12	A	H4'	H	4.642	0.000	1
64	1	12	A	H8	H	8.543	0.001	1
65	1	13	U	H1'	H	5.969	0.001	1
66	1	13	U	H2'	H	4.481	0.004	1
67	1	13	U	H5	H	5.829	0.000	1
68	1	13	U	H6	H	7.865	0.002	1
69	1	14	G	H1	H	11.618	0.002	1
70	1	14	G	H1'	H	5.796	0.000	1
71	1	14	G	H2'	H	4.824	0.002	1
72	1	14	G	H3'	H	4.721	0.000	1
73	1	14	G	H8	H	8.072	0.001	1
74	1	15	G	H1	H	11.533	0.003	1
75	1	15	G	H1'	H	5.868	0.001	1
76	1	15	G	H2'	H	4.501	0.003	1
77	1	15	G	H3'	H	4.628	0.003	1
78	1	15	G	H8	H	7.955	0.000	1
79	1	16	G	H1	H	11.241	0.002	1
80	1	16	G	H1'	H	6.032	0.000	1
81	1	16	G	H2'	H	4.612	0.000	1
82	1	16	G	H3'	H	4.819	0.000	1
83	1	16	G	H8	H	7.931	0.002	1
84	1	17	U	H1'	H	6.038	0.000	1
85	1	17	U	H5	H	6.010	0.000	1
86	1	17	U	H6	H	7.969	0.001	1
87	1	18	C	H1'	H	6.016	0.000	1
88	1	18	C	H2'	H	4.437	0.000	1
89	1	18	C	H5	H	6.158	0.000	1
90	1	18	C	H6	H	8.016	0.001	1
91	1	19	C	H1'	H	6.099	0.002	1
92	1	19	C	H5	H	6.165	0.000	1
93	1	19	C	H6	H	7.953	0.002	1
94	1	20	G	H1	H	11.681	0.001	1
95	1	20	G	H1'	H	5.825	0.003	1
96	1	20	G	H2'	H	4.937	0.003	1
97	1	20	G	H3'	H	4.789	0.000	1
98	1	20	G	H4'	H	4.580	0.000	1
99	1	20	G	H8	H	8.093	0.001	1
100	1	21	G	H1	H	11.412	0.001	1
101	1	21	G	H1'	H	6.039	0.001	1
102	1	21	G	H2'	H	4.523	0.002	1
103	1	21	G	H8	H	8.032	0.001	1
104	1	22	G	H1	H	11.528	0.002	1
105	1	22	G	H1'	H	6.099	0.001	1
106	1	22	G	H2'	H	4.408	0.002	1
107	1	22	G	H3'	H	4.719	0.001	1
108	1	22	G	H8	H	7.776	0.000	1
109	1	23	U	H1'	H	5.553	0.000	1
110	1	23	U	H2'	H	3.910	0.000	1
111	1	23	U	H3'	H	4.089	0.000	1
112	1	23	U	H5	H	5.444	0.001	1
113	1	23	U	H6	H	7.441	0.001	1

Release date

2023-11-14

Citation

High-Resolution Structure of RNA G-Quadruplex Containing Unique Structural Motifs Originating from the 5'-UTR of Human Tyrosine Kinase 2 (TYK2)
Orehova, M., Plavec, J., Kocman, V.
ACS Omega (2024), 9, 7215-7229, PubMed 38371751 , DOI 10.1021/acsomega.3c09592 , Abstract

Experiments performed 4 experiments Detail

Chemical shift validation 3 contents Detail