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BMRB: 36116


36116
5YEY
The structure of a chair-type G-quadruplex of the human telomeric variant in K+ solution
Authors
Liu, C., Zhou, B., Kuryavyi, V.V., Zhu, G.
Assembly
DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*TP*GP*GP*G)-3')
Entity
1. DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*TP*GP*GP*G)-3') (polymer, Thiol state: not present), 21 monomers, 6724.246 Da Detail

GGGTTAGGGT TAGGGTTTGG G


Formula weight
6724.246 Da
Source organism
Homo sapiens
Exptl. method
solution NMR
Data set
assigned_chemical_shifts
Chem. Shift Complete
Sequence coverage: 100.0 %, Completeness: 76.5 %, Completeness (bb): 72.1 % Detail
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Polymer type: polydeoxyribonucleotide

Total1H
All76.5 % (150 of 196)76.5 % (150 of 196)
Suger, PO472.1 % (106 of 147)72.1 % (106 of 147)
Nucleobase89.8 % (44 of 49)89.8 % (44 of 49)
Aromatic88.1 % (37 of 42)88.1 % (37 of 42)
Methyl100.0 % (7 of 7)100.0 % (7 of 7)

1. DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*TP*GP*GP*G)-3')

GGGTTAGGGT TAGGGTTTGG G

Show sample condition
Sample #1

Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 284 K, pH 7, Details 2.5 mM DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*TP*GP*GP*G)-3'), 90% H2O/10% D2O


#NameIsotope labelingTypeConcentration
1DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*TP*GP*GP*G)-3')natural abundanceDNA2.5 mM
2Potassium Phosphatenatural abundancebuffer20 mM
3KClnatural abundancesalt70 mM
4H2Onatural abundancesolvent90 %
5D2O[U-2H]solvent10 %
Sample #2

Solvent system 100% D2O, Pressure 1 atm, Temperature 284 K, pH 7, Details 2.5 mM DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*TP*GP*GP*G)-3'), 100% D2O


#NameIsotope labelingTypeConcentration
6DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*TP*GP*GP*G)-3')natural abundanceDNA2.5 mM
7Potassium Phosphatenatural abundancebuffer20 mM
8KClnatural abundancesalt70 mM
9D2O[U-2H]solvent100 %

Release date
2017-10-19
Citation
A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K+ solution
Liu, C., Zhou, B., Geng, Y., Yan Tam, D., Feng, R., Miao, H., Xu, N., Shi, X., You, Y., Hong, Y., Tang, B.Z., Kwan Lo, P., Kuryavyi, V., Zhu, G.
Chem. Sci. (2019), 10, 218-226, PubMed 30713633 , DOI 10.1039/c8sc03813a ,
Related entities 1. DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*TP*GP*GP*G)-3'), : 1 : 1 entities Detail
More details for 2 related entities
Experiments performed 5 experiments Detail
NMR combined restraints 5 contents Detail
Keywords DNA, G-quadruplex