BMRB: 4201

Role of the 6-20 Disulfide Bridge in the Structure and Activity of Epidermal Growth Factor

Authors

Barnham, K.J., Torres, A.M., Alewood, D., Alewood, P.F., Domagala, T., Nice, E.C., Norton, R.S.

Assembly

[ABA6,20] mEGF4-48

Entity

1. [ABA6,20] mEGF4-48 (polymer, Thiol state: not reported), 45 monomers, 4874.367 Da Detail

PGXPSSYDGY CLNGGVXMHI ESLDSYTCNC VIGYSGDRCQ TRDLR

Formula weight

4874.367 Da

Source organism

Mus musculus

Exptl. method

NMR

Refine. method

SIMULATED ANNEALING

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 95.6 %, Completeness: 97.9 %, Completeness (bb): 100.0 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	97.9 % (230 of 235)	97.9 % (230 of 235)
Backbone	100.0 % (90 of 90)	100.0 % (90 of 90)
Sidechain	96.6 % (140 of 145)	96.6 % (140 of 145)
Aromatic	94.4 % (17 of 18)	94.4 % (17 of 18)
Methyl	93.8 % (15 of 16)	93.8 % (15 of 16)

1. [ABA6,20] mEGF4-48

PGXPSSYDGY CLNGGVXMHI ESLDSYTCNC VIGYSGDRCQ TRDLR

Show sample condition

Sample

Temperature 300 (±1) K, pH 2.8 (±0.2)

#	Name	Isotope labeling	Type	Concentration
1	[ABA6,20]_mEGF4-48			0.0 ~ 0.0 mM

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Calculated from 20 models in PDB: 1A3P, Strand ID: A Detail

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Release date

2000-03-07

Citation

Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor
Barnham, K.J., Torres, A.M., Alewood, D., Alewood, P.F., Domagala, T., Nice, E.C., Norton, R.S.
Protein Sci. (1998), 7, 1738-1749, PubMed 10082370 , DOI 10.1002/pro.5560070808 , Abstract

Related entities 1. [ABA6,20] mEGF4-48, : 1 : 8 : 157 entities Detail

Interaction partners 1. [ABA6,20] mEGF4-48, : 5 interactors Detail

Experiments performed 1 experiments Detail