BMRB: 4595

Cystic fibrosis transmembrane conductance regulator: solution structures of peptides based on the Phe508 region, the most common site of disease-causing DeltaF508 mutation -- P25

Authors

Massiah, M.A., Ko, Y.H., Pedersen, P.L., Mildvan, A.S.

Assembly

cystic fibrosis transmembrane conductance regulator (CFTR)

Entity

1. cystic fibrosis transmembrane conductance regulator (CFTR) (polymer, Thiol state: not present), 25 monomers, 2903.313 Da Detail

MPGTIKENII GVSYDEYRYR SVIKA

Formula weight

2903.313 Da

Source organism

Homo sapiens

Exptl. method

NMR

Refine. method

DISTANCE GEOMETRY

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 80.9 %, Completeness (bb): 96.1 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	80.9 % (127 of 157)	80.9 % (127 of 157)
Backbone	96.1 % (49 of 51)	96.1 % (49 of 51)
Sidechain	73.6 % (78 of 106)	73.6 % (78 of 106)
Aromatic	100.0 % (12 of 12)	100.0 % (12 of 12)
Methyl	100.0 % (14 of 14)	100.0 % (14 of 14)

1. protein (cystic fibrosis transmembrane conductance regulator (CFTR))

MPGTIKENII GVSYDEYRYR SVIKA

Show sample condition

Sample

Pressure 1 atm, Temperature 298 (±0.5) K, pH 4.0 (±0.1)

#	Name	Isotope labeling	Type	Concentration
1	protein (cystic fibrosis transmembrane conductance regulator (CFTR))			1.4 mM
2	Trifluroethanol			43 %

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Protein Blocks Logo

Calculated from 13 models in PDB: 1CKW, Strand ID: A Detail

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Release date

2000-12-03

Citation

Cystic fibrosis transmembrane conductance regulator: solution structures of peptides based on the Phe508 region, the most common site of disease-causing DeltaF508 mutation
Massiah, M.A., Ko, Y.H., Pedersen, P.L., Mildvan, A.S.
Biochemistry (1999), 38, 7453-7461, PubMed 10360942 , DOI 10.1021/bi9903603 , Abstract

Related entities 1. cystic fibrosis transmembrane conductance regulator (CFTR), : 1 : 6 : 1 : 78 entities Detail

Interaction partners 1. cystic fibrosis transmembrane conductance regulator (CFTR), : 29 interactors Detail

Experiments performed 3 experiments Detail