BMRB: 4610

NMR Observation of A-tetrad in a DNA Quadruplex

Authors

Patel, P.K., Koti, A.S.R., Hosur, R.V.

Assembly

5'-D(*AP*GP*GP*GP*T)-3'

Entity

1. 5'-D(*AP*GP*GP*GP*T)-3' (polymer, Thiol state: not present), 5 monomers, 1623.032 × 4 Da Detail

AGGGT

Total weight

6492.128 Da

Max. entity weight

1623.032 Da

Source organism

Homo sapiens

Exptl. method

NMR

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 80.0 %, Completeness: 63.0 %, Completeness (bb): 71.4 % Detail

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Polymer type: polydeoxyribonucleotide

	Total	1H
All	63.0 % (29 of 46)	63.0 % (29 of 46)
Suger, PO4	71.4 % (25 of 35)	71.4 % (25 of 35)
Nucleobase	36.4 % (4 of 11)	36.4 % (4 of 11)
Aromatic	40.0 % (4 of 10)	40.0 % (4 of 10)
Methyl	0.0 % (0 of 1)	0.0 % (0 of 1)

1. AGGGT

AGGGT

Show sample condition

Sample

Pressure 1 atm, pH 7.3

#	Name	Isotope labeling	Type	Concentration
1	AGGGT			1.0 ~ 2.0 mM
2	potassium phosphate			2 mM
3	EDTA			0.2 mM
4	KCl			100.0 mM
5	H2O			90 %
6	D2O			10 %

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Release date

2000-12-21

Citation

NMR studies on truncated sequences of human telomeric DNA: observation of a novel A-tetrad
Patel, P.K., Koti, A.S.R., Hosur, R.V.
Nucleic Acids Res. (1999), 27, 3836-3843, PubMed 10481022 , DOI: , Abstract

Experiments performed 3 experiments Detail