BMRB: 5075

Solution Structure of Human Apolipoprotein(a) Kringle IV type 6

Authors

Maderegger, B., Bermel, W., Hrzenjak, A., Kostner, G.M., Sterk, H.

Assembly

Apolipoprotein(a) kringle IV type 6

Entity

1. Apolipoprotein(a) kringle IV type 6 (polymer, Thiol state: all disulfide bound), 119 monomers, 13571.62 Da Detail

ARIHHHHHHI EGRAPTEQSP GVQDCYHGDG QSYRGSFSTT VTGRTCQSWS SMTPHWHQRT TEYYPNGGLT RNYCRNPDAE ISPWCYTMDP NVRWEYCNLT QCPVTESSVL ATSTAVSEQ

Formula weight

13571.62 Da

Entity Connection

disulfide 3 Detail

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ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	1:CYS25:SG	1:CYS102:SG
2	disulfide	sing	1:CYS46:SG	1:CYS85:SG
3	disulfide	sing	1:CYS74:SG	1:CYS97:SG

Source organism

Homo sapiens

Exptl. method

NMR

Refine. method

distance geometry,

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 94.1 %, Completeness: 79.2 %, Completeness (bb): 89.0 % Detail

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Polymer type: polypeptide(L)

	Total	1H	13C	15N
All	79.2 % (1050 of 1325)	79.7 % (545 of 684)	76.7 % (394 of 514)	87.4 % (111 of 127)
Backbone	89.0 % (621 of 698)	88.2 % (210 of 238)	89.1 % (311 of 349)	90.1 % (100 of 111)
Sidechain	72.0 % (531 of 738)	75.1 % (335 of 446)	67.0 % (185 of 276)	68.8 % (11 of 16)
Aromatic	72.0 % (108 of 150)	78.7 % (59 of 75)	63.4 % (45 of 71)	100.0 % (4 of 4)
Methyl	74.4 % (64 of 86)	86.0 % (37 of 43)	62.8 % (27 of 43)

1. Apolipoprotein(a) kringle IV type6

ARIHHHHHHI EGRAPTEQSP GVQDCYHGDG QSYRGSFSTT VTGRTCQSWS SMTPHWHQRT TEYYPNGGLT RNYCRNPDAE ISPWCYTMDP NVRWEYCNLT QCPVTESSVL ATSTAVSEQ

Show sample condition

Sample

Pressure 1 atm, Temperature 303 (±1) K, pH 6.5 (±0.1)

#	Name	Isotope labeling	Type	Concentration
1	Apolipoprotein(a) kringle IV type6	[U-15N]		0.7 mM
2	phosphate buffer			15 mM
3	NaCl			50 mM
4	H2O			90 %
5	D2O			10 %

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Protein Blocks Logo

Calculated from 15 models in PDB: 1JFN, Strand ID: A Detail

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Release date

2001-07-08

Citation

Solution structure of human apolipoprotein(a) kringle IV type 6
Maderegger, B., Bermel, W., Hrzenjak, A., Kostner, G.M., Sterk, H.
Biochemistry (2002), 41, 660-668, PubMed 11781107 , DOI: , Abstract

Related entities 1. Apolipoprotein(a) kringle IV type 6, : 1 : 1 : 90 entities Detail

Interaction partners 1. Apolipoprotein(a) kringle IV type 6, : 2 interactors Detail

Experiments performed 3 experiments Detail