BMRB: 5173

NMR structure of human Epiregulin

Authors

Sato, K., Miura, K., Tada, M., Aizawa, T., Miyamoto, K., Kawano, K.

Assembly

Epiregulin monomer

Entity

1. Epiregulin monomer (polymer, Thiol state: all disulfide bound), 46 monomers, 5275.029 Da Detail

VSITKCSSDM NGYCLHGQCI YLVDMSQNYC RCEVGYTGVR CEHFFL

Formula weight

5275.029 Da

Entity Connection

disulfide 3 Detail

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ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	0:CYS6:SG	1:CYS19:SG
2	disulfide	sing	0:CYS14:SG	1:CYS30:SG
3	disulfide	sing	0:CYS32:SG	1:CYS41:SG

Source organism

Homo sapiens

Exptl. method

NMR

Refine. method

distance geometry simulated annealing

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 93.6 %, Completeness (bb): 100.0 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	93.6 % (250 of 267)	93.6 % (250 of 267)
Backbone	100.0 % (96 of 96)	100.0 % (96 of 96)
Sidechain	90.1 % (154 of 171)	90.1 % (154 of 171)
Aromatic	93.3 % (28 of 30)	93.3 % (28 of 30)
Methyl	90.0 % (18 of 20)	90.0 % (18 of 20)

1. Epiregulin

VSITKCSSDM NGYCLHGQCI YLVDMSQNYC RCEVGYTGVR CEHFFL

Show sample condition

Sample

Temperature 303 (±1) K, pH 3.4 (±0.1)

#	Name	Isotope labeling	Type	Concentration
1	Epiregulin			1.5 mM

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Protein Blocks Logo

Calculated from 40 models in PDB: 1K36, Strand ID: A Detail

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Release date

2003-12-07

Citation

Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity
Sato, K., Nakamura, T., Mizuguchi, M., Miura, K., Tada, M., Aizawa, T., Gomi, T., Miyamoto, K., Kawano, K.
FEBS Lett. (2003), 553, 232-238, PubMed 14572630 , DOI: , Abstract

Related entities 1. Epiregulin monomer, : 1 : 9 : 188 entities Detail