BMRB: 5383

The CXCR3 binding chemokine IP-10/CXCL10: Structure and receptor interactions

Authors

Booth, V., Keizer, D.W., Kamphuis, M.B., Clark-Lewis, I., Sykes, B.D.

Assembly

IP-10

Entity

1. IP-10 (polymer, Thiol state: all disulfide bound), 77 monomers, 8635.241 Da Detail

VPLSRTVRCT CISISNQPVN PRSLEKXEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK EMSKRSP

Formula weight

8635.241 Da

Entity Connection

disulfide 2 Detail

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ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	1:CYS9:SG	1:CYS36:SG
2	disulfide	sing	1:CYS11:SG	1:CYS53:SG

Exptl. method

NMR

Refine. method

simulated annealing

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 81.8 %, Completeness: 62.7 %, Completeness (bb): 81.5 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	62.7 % (307 of 490)	62.7 % (307 of 490)
Backbone	81.5 % (119 of 146)	81.5 % (119 of 146)
Sidechain	54.7 % (188 of 344)	54.7 % (188 of 344)
Aromatic	100.0 % (5 of 5)	100.0 % (5 of 5)
Methyl	75.6 % (31 of 41)	75.6 % (31 of 41)

1. IP-10

VPLSRTVRCT CISISNQPVN PRSLEKXEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK EMSKRSP

Show sample condition

Sample

Temperature 303 (±0.1) K, pH 5.0 (±0.1)

#	Name	Isotope labeling	Type	Concentration
1	IP-10			2 mM

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Protein Blocks Logo

Calculated from 10 models in PDB: 1LV9, Strand ID: A Detail

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Release date

2002-06-03

Citation

The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions
Booth, V., Keizer, D.W., Kamphuis, M.B., Clark-Lewis, I., Sykes, B.D.
Biochemistry (2002), 41, 10418-10425, PubMed 12173928 , DOI: , Abstract

Entries sharing articles Swiss-Prot: 1 entries Detail

Related entities 1. IP-10, : 1 : 6 : 132 entities Detail

Interaction partners 1. IP-10, : 19 interactors Detail

Experiments performed 2 experiments Detail