BMRB: 5502

Solution Structure of Hepcidin-20

Authors

Hunter, H.N., Fulton, D.B., Ganz, T., Vogel, H.J.

Assembly

Hepcidin

Entity

1. Hepcidin (polymer, Thiol state: all disulfide bound), 20 monomers, 2199.795 Da Detail

ICIFCCGCCH RSKCGMCCKT

Formula weight

2199.795 Da

Entity Connection

disulfide 4 Detail

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ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	1:CYS2:SG	1:CYS18:SG
2	disulfide	sing	1:CYS5:SG	1:CYS17:SG
3	disulfide	sing	1:CYS6:SG	1:CYS14:SG
4	disulfide	sing	1:CYS8:SG	1:CYS9:SG

Source organism

Homo sapiens

Exptl. method

NMR

Refine. method

simulated annealing, molecular dynamics, matrix relaxation, torsion angle dynamics

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 95.0 %, Completeness: 94.6 %, Completeness (bb): 90.5 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	94.6 % (105 of 111)	94.6 % (105 of 111)
Backbone	90.5 % (38 of 42)	90.5 % (38 of 42)
Sidechain	97.1 % (67 of 69)	97.1 % (67 of 69)
Aromatic	100.0 % (7 of 7)	100.0 % (7 of 7)
Methyl	100.0 % (5 of 5)	100.0 % (5 of 5)

1. hepicidin

ICIFCCGCCH RSKCGMCCKT

Show sample condition

Sample

Pressure 1 atm, Temperature 298 (±1) K, pH 3.2 (±0.2)

#	Name	Isotope labeling	Type	Concentration
1	hepicidin			0.78 mM
2	H2O			90 %
3	D2O			10 %

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Calculated from 20 models in PDB: 1M4E, Strand ID: A Detail

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Release date

2002-08-13

Citation

The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis
Hunter, H.N., Fulton, D.B., Ganz, T., Vogel, H.J.
J. Biol. Chem. (2002), 277, 37597-37603, PubMed 12138110 , DOI 10.1074/jbc.M205305200 , Abstract

Entries sharing articles BMRB: 1, Swiss-Prot: 1 entries Detail

Related entities 1. Hepcidin, : 1 : 8 : 1 : 11 entities Detail

Interaction partners 1. Hepcidin, : 1 interactors Detail

Experiments performed 4 experiments Detail