BMRB: 5913

NMR SOLUTION STRUCTURE OF CN12, A NOVEL ALPHA-SCORPION TOXIN FROM CENTRUROIDES NOXIUS, SHOWING THE IMPORTANCE OF SURFACE CHARGE DISTRIBUTION FOR NA+-CHANNEL AFINITY.

Authors

DEL RIO-PORTILLA, F., POSSANI, L.D., HERNANDEZ-MARIN, E., WANKE, E., PIMIENTA, G., CORONAS, F.V., ZAMUDIO, F.Z.

Assembly

Neurotoxin Cn11

Entity

1. Neurotoxin Cn11 (polymer, Thiol state: all disulfide bound), 67 monomers, 7147.805 Da Detail

RDGYPLASNG CKFGCSGLGE NNPTCNHVCE KKAGSDYGYC YAWTCYCEHV AEGTVLWGDS GTGPCRS

Formula weight

7147.805 Da

Entity Connection

disulfide 4 Detail

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ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	1:CYS11:SG	1:CYS65:SG
2	disulfide	sing	1:CYS15:SG	1:CYS40:SG
3	disulfide	sing	1:CYS25:SG	1:CYS45:SG
4	disulfide	sing	1:CYS29:SG	1:CYS47:SG

Source organism

Centruroides noxius

Exptl. method

NMR

Refine. method

SIMULATED ANNEALING

Data set

coupling_constants

Protein Blocks Logo

Calculated from 19 models in PDB: 1PE4, Strand ID: A Detail

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Coupling constant

22 J values in 1 lists
Pressure 1 atm, Temperature 300 K, pH 3.1 Detail

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Pressure 1 atm, Temperature 300 K, pH 3.1

List #1 coupling_constants_set_1

Release date

2004-08-29

Citation

NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical beta-toxin sequence but with alpha-like physiological activity
DEL RIO-PORTILLA, F., HERNANDEZ-MARIN, E., PIMIENTA, G., CORONAS, F.V., ZAMUDIO, F.Z., Rodriguez de la Vega, R.C., Wanke, E., Possani, L.D.
Eur. J. Biochem. (2004), 271, 2504-2516, PubMed 15182366 , DOI 10.1111/j.1432-1033.2004.04181.x , Abstract

Entries sharing articles Swiss-Prot: 1 entries Detail

Related entities 1. Neurotoxin Cn11, : 1 : 1 : 111 entities Detail

Experiments performed 5 experiments Detail