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BMRB: 5940


5940
2ARW
1H, 15N and 13C backbone assignment of the carboxyl terminal domain of the cytokine binding module of the interleukin-6 receptor (IL-6R)
Authors
Schwantner, A., Dingley, A.J., Ozbek, S., Rose-John, S., Grotzinger, J.
Assembly
third domain of the interleukin-6 receptor
Entity
1. third domain of the interleukin-6 receptor (polymer, Thiol state: all free), 126 monomers, 14663.24 Da Detail

MGILQPDPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTT


Formula weight
14663.24 Da
Source organism
Homo sapiens
Exptl. method
NMR
Refine. method
torsion angle dynamicsu
Data set
assigned_chemical_shifts
Chem. Shift Complete
Sequence coverage: 92.1 %, Completeness: 61.1 %, Completeness (bb): 86.0 % Detail
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Polymer type: polypeptide(L)

Total1H13C15N
All61.1 % (913 of 1494)50.1 % (389 of 777)71.6 % (417 of 582)79.3 % (107 of 135)
Backbone86.0 % (633 of 736)86.6 % (214 of 247)83.9 % (313 of 373)91.4 % (106 of 116)
Sidechain44.1 % (388 of 879)33.0 % (175 of 530)64.2 % (212 of 330) 5.3 % (1 of 19)
Aromatic 5.8 % (10 of 172) 5.8 % (5 of 86) 6.4 % (5 of 78) 0.0 % (0 of 8)
Methyl57.8 % (67 of 116)31.0 % (18 of 58)84.5 % (49 of 58)

1. interleukin-6 receptor

MGILQPDPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTT

Show sample condition
Sample

Temperature 293 (±0.1) K, pH 5.0 (±0.1)


#NameIsotope labelingTypeConcentration
1interleukin-6 receptor[U-95% 13C; U-90% 15N]1.0 mM

LACS Plot; CA
Referencing offset: -0.01 ppm, Outliers: 2 Detail
LACS Plot; CB
Referencing offset: -0.01 ppm, Outliers: 2 Detail
LACS Plot; HA
Referencing offset: -0.02 ppm, Outliers: 2 Detail
LACS Plot; CO
Referencing offset: 0.17 ppm, Outliers: 3 Detail
Protein Blocks Logo
Calculated from 1 models in PDB: 2ARW, Strand ID: A Detail

Release date
2004-07-05
Citation 1
1H, 15N and 13C backbone assignment of the carboxyl terminal domain of the cytokine binding module of the interleukin-6 receptor
Schwantner, A., Dingley, A.J., Ozbek, S., Hecht, O., Rose-John, S., Grotzinger, J.
J. Biomol. NMR (2004), 29, 407-408, PubMed 15213442 , DOI 10.1023/B:JNMR.0000032500.87876.e5 ,
Show more 1 citaion
Citation 2
Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy
Schwantner, A., Dingley, A.J., Ozbek, S., Rose-John, S., Grotzinger, J.
J. Biol. Chem. (2004), 279, 571-576, PubMed 14557255 , DOI 10.1074/jbc.M311019200 ,
Related entities 1. third domain of the interleukin-6 receptor, : 1 : 5 : 83 entities Detail
More details for 89 related entities
Interaction partners 1. third domain of the interleukin-6 receptor, : 7 interactors Detail
More details for 7 interactors identified by 5 citations
nullKeywords 3D NMR, backbone assignment, IL-6R, cytokine receptor, FN III domain