BMRB: 6020

Structure-activity relationships for the beta-hairpin cationic antimicrobial peptide polyphemusin I

Authors

Powers, J.S., Rozek, A., Hancock, R.E.W.

Assembly

Polyphemusin I

Entity

1. Polyphemusin I (polymer, Thiol state: all disulfide bound), 19 monomers, 2456.967 Da Detail

RRWCFRVCYR GFCYRKCRX

Formula weight

2456.967 Da

Entity Connection

disulfide 2 Detail

---

ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	1:CYS4:SG	1:CYS17:SG
2	disulfide	sing	1:CYS4:SG	1:CYS17:SG

Source organism

Tachypleus sp.

Exptl. method

NMR

Refine. method

DISTANCE GEOMETRY WITH SIMULATED ANNEALING

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 94.7 %, Completeness: 98.5 %, Completeness (bb): 97.3 % Detail

Download

• NMR-STAR v3.1 (partial)
• BMRB/XML (partial)
• CSV
• TSV

Polymer type: polypeptide(L)

	Total	1H
All	98.5 % (130 of 132)	98.5 % (130 of 132)
Backbone	97.3 % (36 of 37)	97.3 % (36 of 37)
Sidechain	98.9 % (94 of 95)	98.9 % (94 of 95)
Aromatic	95.8 % (23 of 24)	95.8 % (23 of 24)
Methyl	100.0 % (2 of 2)	100.0 % (2 of 2)

1. Polyphemusin I

RRWCFRVCYR GFCYRKCRX

Show sample condition

Sample

Temperature 300 (±1) K, pH 4.0 (±0.2)

#	Name	Isotope labeling	Type	Concentration
1	Polyphemusin I			2 mM

Hide sample codition

Protein Blocks Logo

Calculated from 17 models in PDB: 1RKK, Strand ID: A Detail

---

Release date

2008-07-15

Citation

Structure-activity relationships for the beta-hairpin cationic antimicrobial peptide polyphemusin I
Powers, J.S., Rozek, A., Hancock, R.E.W.
Biochim. Biophys. Acta (2004), 1698, 239-250, PubMed 15134657 , DOI 10.1016/j.bbapap.2003.12.009 , Abstract

Entries sharing articles Swiss-Prot: 1 entries Detail

Related entities 1. Polyphemusin I, : 1 : 4 : 21 entities Detail

Experiments performed 3 experiments Detail