BMRB: 6027

NMR Solution Structure of PIIIA toxin, NMR, 20 structures

Authors

Nielsen, K.J., Watson, M., Adams, D.J., Hammarstrom, A.K., Gage, P.W., Hill, J.M., Craik, D.J., Thomas, L., Adams, D., Alewood, P.F., Lewis, R.J.

Assembly

Mu-conotoxin PIIIA

Entity

1. Mu-conotoxin PIIIA (polymer, Thiol state: free and disulfide bound), 22 monomers, 2506.958 Da Detail

XRLCCGFXKS CRSRQCKXHR CX

Formula weight

2506.958 Da

Entity Connection

disulfide 2 Detail

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ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	0:CYS5:SG	1:CYS21:SG
2	disulfide	sing	0:CYS4:SG	1:CYS16:SG

Source organism

Conus purpurascens

Exptl. method

NMR

Refine. method

Torsion angle dynamics, simulated annealing

Data set

homonucl_NOEs

Protein Blocks Logo

Calculated from 20 models in PDB: 1R9I, Strand ID: A Detail

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Release date

2004-02-10

Citation

Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels
Nielsen, K.J., Watson, M., Adams, D.J., Hammarstrom, A.K., Gage, P.W., Hill, J.M., Craik, D.J., Thomas, L., Adams, D., Alewood, P.F., Lewis, R.J.
J. Biol. Chem. (2002), 277, 27247-27255, PubMed 12006587 , DOI 10.1074/jbc.M201611200 , Abstract

Related entities 1. Mu-conotoxin PIIIA, : 1 : 1 : 4 entities Detail

Experiments performed 4 experiments Detail