BMRB: 6083

Specific recognition between surface loop 2 (132-143) and helix 1 (144-154) within sheep prion protein from in vitro studies of synthetic peptides

Authors

Kozin, S.A., Lepage, C., Hui Bon Hoa, G., Rabesona, H., Mazur, A.K., Blond, A., Cheminant, M., Haertle, T., Debey, P., Rebuffat, S.

Assembly

SheepPrP(135-155)

Entity

1. SheepPrP(135-155) (polymer, Thiol state: not present), 21 monomers, 2738.944 Da Detail

SRPLIHFGND YEDRYYRENM Y

Formula weight

2738.944 Da

Source organism

Ovis aries

Exptl. method

NMR

Refine. method

Molecular dynamics with AMBER99 all-atom force field parameters by using the variable target function approach in the torsion angle space with the standard geometry of amino acids and peptide bonds.

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 94.3 %, Completeness (bb): 97.6 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	94.3 % (133 of 141)	94.3 % (133 of 141)
Backbone	97.6 % (41 of 42)	97.6 % (41 of 42)
Sidechain	92.9 % (92 of 99)	92.9 % (92 of 99)
Aromatic	95.7 % (22 of 23)	95.7 % (22 of 23)
Methyl	100.0 % (4 of 4)	100.0 % (4 of 4)

1. Sheep prion protein peptide 135-155 (in human numbering)

SRPLIHFGND YEDRYYRENM Y

Show sample condition

Sample

#	Name	Isotope labeling	Type	Concentration
1	Sheep prion protein peptide 135-155 (in human numbering)			5.0 mM

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Protein Blocks Logo

Calculated from 20 models in PDB: 1S4T, Strand ID: A Detail

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Release date

2004-03-06

Citation

Specific recognition between surface loop 2 (132-143) and helix 1 (144-154) within sheep prion protein from in vitro studies of synthetic peptides
Kozin, S.A., Lepage, C., Hui Bon Hoa, G., Rabesona, H., Mazur, A.K., Blond, A., Cheminant, M., Haertle, T., Debey, P., Rebuffat, S.
J. Biol. Chem. (2004), PubMed , DOI:

Related entities 1. SheepPrP(135-155), : 1 : 49 : 85 : 1 : 11 entities Detail

Interaction partners 1. SheepPrP(135-155), : 1 interactors Detail