BMRB: 6219

Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs

Authors

Lee, K., Shin, S.Y., Kim, K., Lim, S.S., Hahm, K.S., Kim, Y.

Assembly

Cytotoxic linear peptide IsCT

Entity

1. Cytotoxic linear peptide IsCT (polymer, Thiol state: not present), 13 monomers, 1501.899 Da Detail

ILGKIWKGIK SLX

Formula weight

1501.899 Da

Source organism

Opisthacanthus madagascariensis

Exptl. method

NMR

Refine. method

distance geometry, simulated annealing

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 84.6 %, Completeness: 69.4 %, Completeness (bb): 84.6 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	69.4 % (59 of 85)	69.4 % (59 of 85)
Backbone	84.6 % (22 of 26)	84.6 % (22 of 26)
Sidechain	62.7 % (37 of 59)	62.7 % (37 of 59)
Aromatic	100.0 % (6 of 6)	100.0 % (6 of 6)
Methyl	70.0 % (7 of 10)	70.0 % (7 of 10)

1. IsCT

ILGKIWKGIK SLX

Show sample condition

Sample

Pressure 1 atm, Temperature 308 K, pH 4.0

#	Name	Isotope labeling	Type	Concentration
1	IsCT			1.0 mM
2	SDS-d25			200 mM
3	H2O			90 %
4	D2O			10 %

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Protein Blocks Logo

Calculated from 20 models in PDB: 1T52, Strand ID: A Detail

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Release date

2008-07-16

Citation

Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs
Lee, K., Shin, S.Y., Kim, K., Lim, S.S., Hahm, K.S., Kim, Y.
Biochem. Biophys. Res. Commun. (2004), 323, 712-719, PubMed 15369808 , DOI 10.1016/j.bbrc.2004.08.144 , Abstract

Entries sharing articles BMRB: 3, Swiss-Prot: 1 entries Detail

Related entities 1. Cytotoxic linear peptide IsCT, : 1 : 4 entities Detail

Experiments performed 3 experiments Detail