BMRB: 6245

Solution Structure of GIP(1-30)amide in TFE/Water

Authors

Alana, I., Hewage, C., Malthouse, J.P.G., Parker, J., Gault, V.A., O'Harte, F.P.M.

Assembly

Gastric inhibitory polypeptide

Entity

1. Gastric inhibitory polypeptide (polymer, Thiol state: not present), 31 monomers, 3530.935 Da Detail

YAEGTFISDY SIAMDKIHQQ DFVNWLLAQK X

Formula weight

3530.935 Da

Source organism

Homo sapiens

Exptl. method

NMR

Refine. method

TORSION ANGLE DYNAMICS, SIMULATED ANNEALING, CONJUGATE-GRADIENT MINIMISATION, POWELL MINIMISATION

Data set

assigned_chemical_shifts, coupling_constants

Chem. Shift Complete

Sequence coverage: 80.6 %, Completeness: 41.8 %, Completeness (bb): 3.3 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	41.8 % (79 of 189)	41.8 % (79 of 189)
Backbone	3.3 % (2 of 61)	3.3 % (2 of 61)
Sidechain	60.2 % (77 of 128)	60.2 % (77 of 128)
Aromatic	46.2 % (12 of 26)	46.2 % (12 of 26)
Methyl	56.3 % (9 of 16)	56.3 % (9 of 16)

1. Gastric inhibitory polypeptide

YAEGTFISDY SIAMDKIHQQ DFVNWLLAQK X

Show sample condition

Sample

Pressure 1 atm, Temperature 298 K, pH 3.0

#	Name	Isotope labeling	Type	Concentration
1	Gastric inhibitory polypeptide			2 mM
2	H2O			50 %
3	d3-TFE			50 %

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Calculated from 20 models in PDB: 1T5Q, Strand ID: A Detail

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Coupling constant

16 J values in 1 lists
Field strength (¹H) 900 MHz, Pressure 1 atm, Temperature 298 K, pH 3.0 Detail

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Pressure 1 atm, Temperature 298 K, pH 3.0

List #1 J_values_set_1, Field strength (¹H) 900 MHz

Release date

2008-07-15

Citation

NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide
Alana, I., Hewage, C.M., Malthouse, J.P.G., Parker, J.C., Gault, V.A., O'Harte, F.P.M.
Biochem. Biophys. Res. Commun. (2004), 325, 281-286, PubMed 15522230 , DOI 10.1016/j.bbrc.2004.10.033 , Abstract

Entries sharing articles BMRB: 1, Swiss-Prot: 1 entries Detail

Related entities 1. Gastric inhibitory polypeptide, : 1 : 13 : 168 entities Detail

Interaction partners 1. Gastric inhibitory polypeptide, : 6 interactors Detail

Experiments performed 5 experiments Detail