BMRB: 6307

The Solution Structure of d(G3T4G4)2

Authors

Sket, P., Crnugelj, M., Plavec, J.

Assembly

5'-D(*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3'

Entity

1. 5'-D(*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3' (polymer, Thiol state: not present), 11 monomers, 3539.226 × 2 Da Detail

GGGTTTTGGG G

Total weight

7078.452 Da

Max. entity weight

3539.226 Da

Exptl. method

NMR

Data set

assigned_chemical_shifts

Chem. Shift Complete1

Sequence coverage: 100.0 %, Completeness: 77.7 %, Completeness (bb): 77.9 % Detail

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Polymer type: polydeoxyribonucleotide

	Total	1H
All	77.7 % (80 of 103)	77.7 % (80 of 103)
Suger, PO4	77.9 % (60 of 77)	77.9 % (60 of 77)
Nucleobase	76.9 % (20 of 26)	76.9 % (20 of 26)
Aromatic	72.7 % (16 of 22)	72.7 % (16 of 22)
Methyl	100.0 % (4 of 4)	100.0 % (4 of 4)

1. G-quadruplex

GGGTTTTGGG G

Show sample condition

Sample

Pressure 1 atm, Temperature 278 (±0.5) K, pH 5.5 (±0.2)

#	Name	Isotope labeling	Type	Concentration
1	G-quadruplex			4 mM
2	KCl			15 mM
3	H2O			90 %
4	D2O			10 %

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Chem. Shift Complete2

Sequence coverage: 100.0 %, Completeness: 78.6 %, Completeness (bb): 77.9 % Detail

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Polymer type: polydeoxyribonucleotide

	Total	1H
All	78.6 % (162 of 206)	78.6 % (162 of 206)
Suger, PO4	77.9 % (120 of 154)	77.9 % (120 of 154)
Nucleobase	80.8 % (42 of 52)	80.8 % (42 of 52)
Aromatic	77.3 % (34 of 44)	77.3 % (34 of 44)
Methyl	100.0 % (8 of 8)	100.0 % (8 of 8)

1. G-quadruplex

GGGTTTTGGG G

Show sample condition

Sample

Pressure 1 atm, Temperature 278 (±0.5) K, pH 5.5 (±0.2)

#	Name	Isotope labeling	Type	Concentration
1	G-quadruplex			4 mM
2	KCl			15 mM
3	H2O			90 %
4	D2O			10 %

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Release date

2004-12-05

Citation

d(G3T4G4) forms unusual dimeric G-quadruplex structure with the same general fold in the presence of K+, Na+ or NH4+ ions
Sket, P., Crnugelj, M., Plavec, J.
Bioorg. Med. Chem. (2004), 12, 5735-5744, PubMed 15498650 , DOI 10.1016/j.bmc.2004.08.009 , Abstract

Related entities 1. 5'-D(*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3', : 1 entities Detail

Experiments performed 3 experiments Detail