BMRB: 6750

Structural basis for cooperative transcription factor binding to the CBP coactivator

Authors

De Guzman, R.N., Wright, P.E.

Assembly

MYB-KIX-MLL COMPLEX

Entity

1. MYB (polymer, Thiol state: not present), 25 monomers, 2942.428 Da Detail

KEKRIKELEL LLMSTENELK GQQAL

2. KIX (polymer, Thiol state: not reported), na Da
3. MLL (polymer, Thiol state: not reported), na Da

Formula weight

2942.428 Da

Source organism

Mus musculus

Exptl. method

NMR

Refine. method

DYANA & AMBER

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 78.9 %, Completeness (bb): 80.0 % Detail

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Polymer type: polypeptide(L)

	Total	1H	13C	15N
All	78.9 % (251 of 318)	79.5 % (136 of 171)	77.3 % (92 of 119)	82.1 % (23 of 28)
Backbone	80.0 % (120 of 150)	90.2 % (46 of 51)	68.9 % (51 of 74)	92.0 % (23 of 25)
Sidechain	80.7 % (155 of 192)	75.0 % (90 of 120)	94.2 % (65 of 69)	0.0 % (0 of 3)
Methyl	100.0 % (32 of 32)	100.0 % (16 of 16)	100.0 % (16 of 16)

1. MYB

KEKRIKELEL LLMSTENELK GQQAL

Show sample condition

Sample

Temperature 298 (±0.1) K

#	Name	Isotope labeling	Type	Concentration
1	MYB			0.0 ~ 0.0 mM
2	KIX			0.0 ~ 0.0 mM
3	MLL			0.0 ~ 0.0 mM

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Protein Blocks Logo

Calculated from 20 models in PDB: 2AGH, Strand ID: A Detail

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Release date

2006-04-26

Citation

Structural basis for cooperative transcription factor binding to the CBP coactivator
De Guzman, R.N., Goto, N.K., Dyson, H., Wright, P.E.
J. Mol. Biol. (2006), 355, 1005-1013, PubMed 16253272 , DOI 10.1016/j.jmb.2005.09.059 , Abstract

Related entities 1. MYB, : 1 : 8 : 1 : 2 : 9 entities Detail

Interaction partners 1. MYB, : 2 interactors Detail