BMRB: 6891

Solution structure of MrIA

Authors

Craik, D.J., Daly, N.L.

Assembly

MrIA

Entity

1. MrIA (polymer, Thiol state: all disulfide bound), 14 monomers, 1410.687 Da Detail

NGVCCGYKLC HXCX

Formula weight

1410.687 Da

Entity Connection

disulfide 2 Detail

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ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	1:CYS4:SG	1:CYS13:SG
2	disulfide	sing	1:CYS5:SG	1:CYS10:SG

Source organism

Conus marmoreus

Exptl. method

NMR

Refine. method

torsion angle dynamics

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 85.7 %, Completeness: 96.9 %, Completeness (bb): 96.2 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	96.9 % (62 of 64)	96.9 % (62 of 64)
Backbone	96.2 % (25 of 26)	96.2 % (25 of 26)
Sidechain	97.4 % (37 of 38)	97.4 % (37 of 38)
Aromatic	83.3 % (5 of 6)	83.3 % (5 of 6)
Methyl	100.0 % (4 of 4)	100.0 % (4 of 4)

1. MrIA

NGVCCGYKLC HXCX

Show sample condition

Sample

Pressure 1 atm, Temperature 287 K, pH 3.5

#	Name	Isotope labeling	Type	Concentration
1	MrIA			2 mM
2	H2O			90 %
3	D2O			10 %

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Calculated from 20 models in PDB: 2EW4, Strand ID: A Detail

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Release date

2005-11-28

Citation

Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter
Nilsson, K.P.R., Lovelace, E.S., Caesar, C.E., Tynngard, N., Alewood, P.F., Johansson, H.M., Sharpe, I.A., Lewis, R.J., Daly, N.L., Craik, D.J.
Biopolymers (2005), 80, 815-823, PubMed 15931669 , DOI 10.1002/bip.20302 , Abstract

Related entities 1. MrIA, : 1 : 3 : 1 entities Detail

Experiments performed 4 experiments Detail