BMRB: 6951

Solution structure of conotoxin pl14a

Authors

Craik, D.J., Daly, N.L.

Assembly

Conotoxin pl14a

Entity

1. Conotoxin pl14a (polymer, Thiol state: all disulfide bound), 26 monomers, 2914.486 Da Detail

FPRPRICNLA CRAGIGHKYP FCHCRX

Formula weight

2914.486 Da

Entity Connection

disulfide 2 Detail

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ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	1:CYS7:SG	1:CYS22:SG
2	disulfide	sing	1:CYS11:SG	1:CYS24:SG

Source organism

Conus planorbis

Exptl. method

NMR

Refine. method

torsion angle dynamics

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 96.2 %, Completeness: 75.0 %, Completeness (bb): 98.0 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	75.0 % (120 of 160)	75.0 % (120 of 160)
Backbone	98.0 % (48 of 49)	98.0 % (48 of 49)
Sidechain	64.9 % (72 of 111)	64.9 % (72 of 111)
Aromatic	27.8 % (5 of 18)	27.8 % (5 of 18)
Methyl	100.0 % (8 of 8)	100.0 % (8 of 8)

1. Conotoxin pl14a

FPRPRICNLA CRAGIGHKYP FCHCRX

Show sample condition

Sample

Pressure 1 atm, Temperature 290 K, pH 3

#	Name	Isotope labeling	Type	Concentration
1	Conotoxin pl14a			1 mM
2	H2O			95 %
3	D2O			5 %

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Calculated from 20 models in PDB: 2FQC, Strand ID: A Detail

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Release date

2008-07-15

Citation

A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins
Imperial, J.S., Bansal, P.S., Alewood, P.F., Daly, N.L., Craik, D.J., Sporning, A., Terlau, H., Lopez-Vera, E., Bandyopadhyay, P.K., Olivera, B.M.
Biochemistry (2006), 45, 8331-8340, PubMed 16819832 , DOI 10.1021/bi060263r , Abstract

Entries sharing articles Swiss-Prot: 6 entries Detail

Related entities 1. Conotoxin pl14a, : 1 : 1 : 6 entities Detail

Experiments performed 4 experiments Detail