BMRB: 7001

Structure of the Phosphorylation Motif of the oncogenic Protein beta-Catenin Recognized By a Selective Monoclonal Antibody

Authors

Megy, S., Bertho, G., Gharbi-Benarous, J., Baleux, F., Benarous, R., Girault, J.

Assembly

P-beta-Cat 19-44

Entity

1. P-beta-Cat 19-44 (polymer, Thiol state: not present), 28 monomers, 2925.923 Da Detail

XKAAVSHWQQ QSYLDXGIHX GATTTAPX

Formula weight

2925.923 Da

Source organism

Homo sapiens

Exptl. method

NMR

Refine. method

distance geometry, simulated annealing, torsion angle dynamics

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 85.7 %, Completeness: 100.0 %, Completeness (bb): 100.0 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	100.0 % (132 of 132)	100.0 % (132 of 132)
Backbone	100.0 % (49 of 49)	100.0 % (49 of 49)
Sidechain	100.0 % (83 of 83)	100.0 % (83 of 83)
Aromatic	100.0 % (14 of 14)	100.0 % (14 of 14)
Methyl	100.0 % (13 of 13)	100.0 % (13 of 13)

1. P-beta-Cat peptide

XKAAVSHWQQ QSYLDXGIHX GATTTAPX

Show sample condition

Sample

Temperature 278 K, pH 7.2

#	Name	Isotope labeling	Type	Concentration
1	P-beta-Cat peptide	not labeled	protein	2 (±0.1) mM
2	Phosphate buffer		buffer	0.0 ~ 0.0 mM

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Calculated from 10 models in PDB: 2G57, Strand ID: A Detail

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Release date

2006-10-18

Citation

STD and TRNOESY NMR studies for the epitope mapping of the phosphorylation motif of the oncogenic protein beta-catenin recognized by a selective monoclonal antibody
Megy, S., Bertho, G., Gharbi-Benarous, J., Baleux, F., Benarous, R., Girault, J.
FEBS Lett. (2006), 580, 5411-5422, PubMed 16996060 , DOI 10.1016/j.febslet.2006.08.084 , Abstract

Related entities 1. P-beta-Cat 19-44, : 1 : 17 : 8 entities Detail

Interaction partners 1. P-beta-Cat 19-44, : 8 interactors Detail

Experiments performed 1 experiments Detail