BMRB: 7067

Human Nogo-A functional domain: nogo60

Authors

Li, M.F., Liu, J.X., Song, J.X.

Assembly

Reticulon-4

Entity

1. Reticulon-4 (polymer, Thiol state: not present), 60 monomers, 6878.733 Da Detail

RIYKGVIQAI QKSDEGHPFR AYLESEVAIS EELVQKYSNS ALGHVNCTIK ELRRLFLVDD

Formula weight

6878.733 Da

Source organism

Homo sapiens

Exptl. method

NMR

Refine. method

distance geometry

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 98.3 %, Completeness: 75.5 %, Completeness (bb): 96.7 % Detail

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Polymer type: polypeptide(L)

	Total	1H	15N
All	75.5 % (329 of 436)	72.8 % (271 of 372)	90.6 % (58 of 64)
Backbone	96.7 % (175 of 181)	96.7 % (118 of 122)	96.6 % (57 of 59)
Sidechain	60.4 % (154 of 255)	61.2 % (153 of 250)	20.0 % (1 of 5)
Aromatic	23.1 % (6 of 26)	23.1 % (6 of 26)
Methyl	67.6 % (25 of 37)	67.6 % (25 of 37)

1. Reticulon-4

RIYKGVIQAI QKSDEGHPFR AYLESEVAIS EELVQKYSNS ALGHVNCTIK ELRRLFLVDD

Show sample condition

Sample

Pressure 1 atm, Temperature 278 K, pH 4.0

#	Name	Isotope labeling	Type	Concentration
1	Reticulon-4
2	H2O			90 %
3	D2O			10 %

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Calculated from 20 models in PDB: 2G31, Strand ID: A Detail

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Release date

2006-11-16

Citation

Nogo goes in the pure water: solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regeneration
Li, M.F., Liu, J.X., Song, J.X.
Protein Sci. (2006), 15, 1835-1841, PubMed 16877707 , DOI 10.1110/ps.062306906 , Abstract

Related entities 1. Reticulon-4, : 1 : 2 : 6 : 40 entities Detail

Interaction partners 1. Reticulon-4, : 49 interactors Detail

Experiments performed 3 experiments Detail