BMRB: 7177

Solution structure of alpha-conotoxin Vc1.1

Authors

Clark, R.J., Fischer, H., Nevin, S.T., Adams, D.J., Craik, D.J.

Assembly

Alpha-conotoxin Vc1A

Entity

1. Alpha-conotoxin Vc1A (polymer, Thiol state: all disulfide bound), 17 monomers, 1810.001 Da Detail

GCCSDPRCNY DHPEICX

Formula weight

1810.001 Da

Entity Connection

disulfide 2 Detail

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ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	1:CYS2:SG	1:CYS8:SG
2	disulfide	sing	1:CYS3:SG	1:CYS16:SG

Exptl. method

NMR

Refine. method

torsion angle dynamics

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 94.1 %, Completeness: 87.4 %, Completeness (bb): 93.5 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	87.4 % (76 of 87)	87.4 % (76 of 87)
Backbone	93.5 % (29 of 31)	93.5 % (29 of 31)
Sidechain	83.9 % (47 of 56)	83.9 % (47 of 56)
Aromatic	66.7 % (4 of 6)	66.7 % (4 of 6)
Methyl	100.0 % (2 of 2)	100.0 % (2 of 2)

1. Alpha-conotoxin Vc1A

GCCSDPRCNY DHPEICX

Show sample condition

Sample

Pressure 1 atm, Temperature 280 K, pH 3.5

#	Name	Isotope labeling	Type	Concentration
1	Alpha-conotoxin Vc1A			1 mM
2	H2O			90 %
3	D2O			10 %

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Calculated from 20 models in PDB: 2H8S, Strand ID: A Detail

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Release date

2006-07-13

Citation

The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1
Clark, R.J., Fischer, H., Nevin, S.T., Adams, D.J., Craik, D.J.
J. Biol. Chem. (2006), 281, 23254-23263, PubMed 16754662 , DOI 10.1074/jbc.M604550200 , Abstract

Entries sharing articles Swiss-Prot: 1 entries Detail

Related entities 1. Alpha-conotoxin Vc1A, : 1 : 8 : 47 entities Detail

Experiments performed 4 experiments Detail