BMRBj - BMREntryMaster

	Total	¹H	¹³C	¹⁵N
All	88.0 % (464 of 527)	90.1 % (245 of 272)	84.4 % (179 of 212)	93.0 % (40 of 43)
Backbone	94.6 % (246 of 260)	97.8 % (88 of 90)	92.2 % (118 of 128)	95.2 % (40 of 42)
Sidechain	83.4 % (256 of 307)	86.3 % (157 of 182)	79.8 % (99 of 124)	0.0 % (0 of 1)
Aromatic	12.5 % (4 of 32)	25.0 % (4 of 16)	0.0 % (0 of 16)
Methyl	92.1 % (70 of 76)	94.7 % (36 of 38)	89.5 % (34 of 38)

1. ErbB4 TM

STLPQHARTP LIAAGVIGGL FILVIVGLTF AVYVRRKSIK KKRA

Show sample condition

Sample

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Protein Blocks Logo

Calculated from 20 models in PDB: 2LCX, Strand ID: A, B Detail

Heteronucl. T₁

36 T₁ values in 1 lists
Coherence Sz, Field strength (¹H) 600 MHz, Temperature 313 (±0.5) K, pH 5.0 (±0.1) Detail

Heteronucl. T₂

34 T₂ values in 1 lists
Coherence S(+,-), Field strength (¹H) 600 MHz, Temperature 313 (±0.5) K, pH 5.0 (±0.1) Detail

Heteronucl. T₁/T₂

34 T₁/T₂ values in 1 lists
Field strength (¹H) 600 MHz, Temperature 313 (±0.5) K, pH 5.0 (±0.1) Detail

Coupling constant

37 J values in 1 lists
Temperature 313 (±0.5) K, pH 5.0 (±0.1) Detail

Release date

2007-01-08

Citation

Spatial structure of the dimeric transmembrane domain of the growth factor receptor ErbB2 presumably corresponding to the receptor active state
Bocharov, E.V., Mineev, K.S., Volynsky, P.E., Ermolyuk, Y.S., Tkach, E.N., Sobol, A.G., Chupin, V.V., Kirpichnikov, M.P., Efremov, R.G., Arseniev, A.S.
J. Biol. Chem. (2008), 283, 6950-6956, PubMed 18178548 , DOI 10.1074/jbc.M709202200 , Abstract

Related entities 1. ErbB4 TM dimer, : 1 : 3 : 44 entities Detail

Interaction partners 1. ErbB4 TM dimer, : 23 interactors Detail

More details for 23 interactors identified by 13 citations

Experiments performed 13 experiments Detail

1 1H15N HSQC

Instrument

Model Varian Unity (600 MHz)

Sample #1

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Sample #2

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N13C: 1.2

#	Name	Isotope labeling	Concentration
4	ErbB4 TM	[U-15N; U-13C]	2.4 (±0.3) mM
5	DMPC	[U-2H]	19 (±1.0) mM
6	DHPC	[U-2H]	77 (±1.0) mM

Sample #3

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM: 0.6 ErbB4TM2labeled: 0.6

#	Name	Isotope labeling	Concentration
7	ErbB4 TM	[U-15N; U-13C]	0.6 (±0.3) mM
8	DMPC	[U-2H]	19 (±1.0) mM
9	DHPC	[U-2H]	77 (±1.0) mM
10	ErbB4 TM	none	0.6 (±0.3) mM

2 1H13C HSQC

Instrument

Model Varian Unity (600 MHz)

Sample #1

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Sample #2

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N13C: 1.2

#	Name	Isotope labeling	Concentration
4	ErbB4 TM	[U-15N; U-13C]	2.4 (±0.3) mM
5	DMPC	[U-2H]	19 (±1.0) mM
6	DHPC	[U-2H]	77 (±1.0) mM

Sample #3

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM: 0.6 ErbB4TM2labeled: 0.6

#	Name	Isotope labeling	Concentration
7	ErbB4 TM	[U-15N; U-13C]	0.6 (±0.3) mM
8	DMPC	[U-2H]	19 (±1.0) mM
9	DHPC	[U-2H]	77 (±1.0) mM
10	ErbB4 TM	none	0.6 (±0.3) mM

3 HCcH-TOCSY

Instrument

Model Varian Unity (600 MHz)

Sample #1

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Sample #2

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N13C: 1.2

#	Name	Isotope labeling	Concentration
4	ErbB4 TM	[U-15N; U-13C]	2.4 (±0.3) mM
5	DMPC	[U-2H]	19 (±1.0) mM
6	DHPC	[U-2H]	77 (±1.0) mM

Sample #3

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM: 0.6 ErbB4TM2labeled: 0.6

#	Name	Isotope labeling	Concentration
7	ErbB4 TM	[U-15N; U-13C]	0.6 (±0.3) mM
8	DMPC	[U-2H]	19 (±1.0) mM
9	DHPC	[U-2H]	77 (±1.0) mM
10	ErbB4 TM	none	0.6 (±0.3) mM

4 3D 13C-ali NOESY

Instrument

Model Varian Unity (600 MHz)

Sample #1

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Sample #2

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N13C: 1.2

#	Name	Isotope labeling	Concentration
4	ErbB4 TM	[U-15N; U-13C]	2.4 (±0.3) mM
5	DMPC	[U-2H]	19 (±1.0) mM
6	DHPC	[U-2H]	77 (±1.0) mM

Sample #3

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM: 0.6 ErbB4TM2labeled: 0.6

#	Name	Isotope labeling	Concentration
7	ErbB4 TM	[U-15N; U-13C]	0.6 (±0.3) mM
8	DMPC	[U-2H]	19 (±1.0) mM
9	DHPC	[U-2H]	77 (±1.0) mM
10	ErbB4 TM	none	0.6 (±0.3) mM

5 3D 15N-NOESY

Instrument

Model Varian Unity (600 MHz)

Sample #1

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Sample #2

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N13C: 1.2

#	Name	Isotope labeling	Concentration
4	ErbB4 TM	[U-15N; U-13C]	2.4 (±0.3) mM
5	DMPC	[U-2H]	19 (±1.0) mM
6	DHPC	[U-2H]	77 (±1.0) mM

Sample #3

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM: 0.6 ErbB4TM2labeled: 0.6

#	Name	Isotope labeling	Concentration
7	ErbB4 TM	[U-15N; U-13C]	0.6 (±0.3) mM
8	DMPC	[U-2H]	19 (±1.0) mM
9	DHPC	[U-2H]	77 (±1.0) mM
10	ErbB4 TM	none	0.6 (±0.3) mM

6 3D 15N-TOCSY

Instrument

Model Varian Unity (600 MHz)

Sample #1

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Sample #2

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N13C: 1.2

#	Name	Isotope labeling	Concentration
4	ErbB4 TM	[U-15N; U-13C]	2.4 (±0.3) mM
5	DMPC	[U-2H]	19 (±1.0) mM
6	DHPC	[U-2H]	77 (±1.0) mM

Sample #3

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM: 0.6 ErbB4TM2labeled: 0.6

#	Name	Isotope labeling	Concentration
7	ErbB4 TM	[U-15N; U-13C]	0.6 (±0.3) mM
8	DMPC	[U-2H]	19 (±1.0) mM
9	DHPC	[U-2H]	77 (±1.0) mM
10	ErbB4 TM	none	0.6 (±0.3) mM

7 HNCA

Instrument

Model Varian Unity (600 MHz)

Sample #1

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Sample #2

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N13C: 1.2

#	Name	Isotope labeling	Concentration
4	ErbB4 TM	[U-15N; U-13C]	2.4 (±0.3) mM
5	DMPC	[U-2H]	19 (±1.0) mM
6	DHPC	[U-2H]	77 (±1.0) mM

Sample #3

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM: 0.6 ErbB4TM2labeled: 0.6

#	Name	Isotope labeling	Concentration
7	ErbB4 TM	[U-15N; U-13C]	0.6 (±0.3) mM
8	DMPC	[U-2H]	19 (±1.0) mM
9	DHPC	[U-2H]	77 (±1.0) mM
10	ErbB4 TM	none	0.6 (±0.3) mM

8 HN(CO)CA

Instrument

Model Varian Unity (600 MHz)

Sample #1

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Sample #2

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N13C: 1.2

#	Name	Isotope labeling	Concentration
4	ErbB4 TM	[U-15N; U-13C]	2.4 (±0.3) mM
5	DMPC	[U-2H]	19 (±1.0) mM
6	DHPC	[U-2H]	77 (±1.0) mM

Sample #3

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM: 0.6 ErbB4TM2labeled: 0.6

#	Name	Isotope labeling	Concentration
7	ErbB4 TM	[U-15N; U-13C]	0.6 (±0.3) mM
8	DMPC	[U-2H]	19 (±1.0) mM
9	DHPC	[U-2H]	77 (±1.0) mM
10	ErbB4 TM	none	0.6 (±0.3) mM

9 HNCO

Instrument

Model Varian Unity (600 MHz)

Sample #1

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Sample #2

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N13C: 1.2

#	Name	Isotope labeling	Concentration
4	ErbB4 TM	[U-15N; U-13C]	2.4 (±0.3) mM
5	DMPC	[U-2H]	19 (±1.0) mM
6	DHPC	[U-2H]	77 (±1.0) mM

Sample #3

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM: 0.6 ErbB4TM2labeled: 0.6

#	Name	Isotope labeling	Concentration
7	ErbB4 TM	[U-15N; U-13C]	0.6 (±0.3) mM
8	DMPC	[U-2H]	19 (±1.0) mM
9	DHPC	[U-2H]	77 (±1.0) mM
10	ErbB4 TM	none	0.6 (±0.3) mM

10 HNHA

Instrument

Model Varian Unity (600 MHz)

Sample #1

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Sample #2

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N13C: 1.2

#	Name	Isotope labeling	Concentration
4	ErbB4 TM	[U-15N; U-13C]	2.4 (±0.3) mM
5	DMPC	[U-2H]	19 (±1.0) mM
6	DHPC	[U-2H]	77 (±1.0) mM

Sample #3

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM: 0.6 ErbB4TM2labeled: 0.6

#	Name	Isotope labeling	Concentration
7	ErbB4 TM	[U-15N; U-13C]	0.6 (±0.3) mM
8	DMPC	[U-2H]	19 (±1.0) mM
9	DHPC	[U-2H]	77 (±1.0) mM
10	ErbB4 TM	none	0.6 (±0.3) mM

11 HNHB

Instrument

Model Varian Unity (600 MHz)

Sample #1

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Sample #2

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N13C: 1.2

#	Name	Isotope labeling	Concentration
4	ErbB4 TM	[U-15N; U-13C]	2.4 (±0.3) mM
5	DMPC	[U-2H]	19 (±1.0) mM
6	DHPC	[U-2H]	77 (±1.0) mM

Sample #3

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM: 0.6 ErbB4TM2labeled: 0.6

#	Name	Isotope labeling	Concentration
7	ErbB4 TM	[U-15N; U-13C]	0.6 (±0.3) mM
8	DMPC	[U-2H]	19 (±1.0) mM
9	DHPC	[U-2H]	77 (±1.0) mM
10	ErbB4 TM	none	0.6 (±0.3) mM

12 2D NC-chirp-NOESY

Instrument

Model Varian Unity (600 MHz)

Sample #1

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Sample #2

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N13C: 1.2

#	Name	Isotope labeling	Concentration
4	ErbB4 TM	[U-15N; U-13C]	2.4 (±0.3) mM
5	DMPC	[U-2H]	19 (±1.0) mM
6	DHPC	[U-2H]	77 (±1.0) mM

Sample #3

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM: 0.6 ErbB4TM2labeled: 0.6

#	Name	Isotope labeling	Concentration
7	ErbB4 TM	[U-15N; U-13C]	0.6 (±0.3) mM
8	DMPC	[U-2H]	19 (±1.0) mM
9	DHPC	[U-2H]	77 (±1.0) mM
10	ErbB4 TM	none	0.6 (±0.3) mM

13 3D C-chirp-NOESY

Instrument

Model Varian Unity (600 MHz)

Sample #1

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N: 1.2

#	Name	Isotope labeling	Concentration
1	ErbB4 TM	[U-15N]	2.4 (±0.3) mM
2	DMPC	[U-2H]	19 (±1.0) mM
3	DHPC	[U-2H]	77 (±1.0) mM

Sample #2

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM15N13C: 1.2

#	Name	Isotope labeling	Concentration
4	ErbB4 TM	[U-15N; U-13C]	2.4 (±0.3) mM
5	DMPC	[U-2H]	19 (±1.0) mM
6	DHPC	[U-2H]	77 (±1.0) mM

Sample #3

Temperature 313 (±0.5) K, pH 5.0 (±0.1), Details DMPC:10 DHPC:40 ErbB4TM: 0.6 ErbB4TM2labeled: 0.6

#	Name	Isotope labeling	Concentration
7	ErbB4 TM	[U-15N; U-13C]	0.6 (±0.3) mM
8	DMPC	[U-2H]	19 (±1.0) mM
9	DHPC	[U-2H]	77 (±1.0) mM
10	ErbB4 TM	none	0.6 (±0.3) mM

nullKeywords dimer, ErbB4, human, kinase, protein, transmembrane

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BMRB: 7205

Sample

Related entities 1. ErbB4 TM dimer, : 1 : 3 : 44 entities Detail

Interaction partners 1. ErbB4 TM dimer, : 23 interactors Detail

Experiments performed 13 experiments Detail

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